The DOI matches its Crossref record; 243 of the 246 references it cites were found in a registry or an index.
Neutrophil chemoattractant receptors in health and disease: double-edged swords
Open accessAbstract
Neutrophils are frontline cells of the innate immune system. These effector leukocytes are equipped with intriguing antimicrobial machinery and consequently display high cytotoxic potential. Accurate neutrophil recruitment is essential to combat microbes and to restore homeostasis, for inflammation modulation and resolution, wound healing and tissue repair. After fulfilling the appropriate effector functions, however, dampening neutrophil activation and infiltration is crucial to prevent damage to the host. In humans, chemoattractant molecules can be categorized into four biochemical families, i.e., chemotactic lipids, formyl peptides, complement anaphylatoxins and chemokines. They are critically involved in the tight regulation of neutrophil bone marrow storage and egress and in spatial and temporal neutrophil trafficking between organs. Chemoattractants function by activating dedicated heptahelical G protein-coupled receptors (GPCRs). In addition, emerging evidence suggests an important role for atypical chemoattractant receptors (ACKRs) that do not couple to G proteins in fine-tuning neutrophil migratory and functional responses. The expression levels of chemoattractant receptors are dependent on the level of neutrophil maturation and state of activation, with a pivotal modulatory role for the (inflammatory) environment. Here, we provide an overview of chemoattractant receptors expressed by neutrophils in health and disease. Depending on the (patho)physiological context, specific chemoattractant receptors may be up- or downregulated on distinct neutrophil subsets with beneficial or detrimental consequences, thus opening new windows for the identification of disease biomarkers and potential drug targets.
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“In the presence of pathogens, different host cells (such as monocytes and macrophages) secrete inflammatory and neutrophil chemoattractant mediators (such as the leukotriene LTB4 involved in inflammation, the interleukin IL-8, and the chemokine CXCL6, a small cytokine belonging to the CXC chemokine family, also known as granulocyte chemotactic protein 2 GCP-2) which bind to specific receptors on”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [215]
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Cambier, S., Gouwy, M., & Proost, P. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00974-6 · Cited by 605
“Eventually, this G proteinmediated signaling induces neutrophil functions like actin polymerization (essential at the leading edge of the neutrophil to allow transmigration), upregulation and activation of adhesion molecules, chemotaxis, phagocytosis, reactive oxygen species (ROS) production, degranulation, and neutro…”
BackgroundSelf-citationNeutrophil extracellular traps in homeostasis and disease
Wang, H., Kim, S. J., Yu, L., Wang, S., Wang, H., Huang, H., Zhang, H., & Tsung, A. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01933-x · Cited by 600
Salcher, S., Sturm, G., Horvath, L., Untergasser, G., Kuempers, C., Fotakis, G., Panizzolo, E., Martowicz, A., Trebo, M., Pall, G., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.10.008 · Cited by 503
Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity
Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Ryan, F. J., Hope, C. M., Masavuli, M. G., Lynn, M. A., Mekonnen, Z. A., Yeow, A. E. L., García-Valtanen, P., Al-Delfi, Z., Gummow, J., Ferguson, C. C., et al. (2022) · BMC Medicine · doi:10.1186/s12916-021-02228-6 · Cited by 288
“CXCR3 LD neutrophils, which are actively recruited to sites of tissue damage [39], were ele-”
Background
Metadata
- Authors
- Metzemaekers, M., Gouwy, M., & Proost, P.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Proost, Paul
- Venue
- Cellular & Molecular Immunology
- Published
- 2020-04-01
- Volume
- 17
- Issue
- 5
- Pages
- 433-450
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC7192912
- OpenAlex
- W3014824156
- Cited by
- 570
- References
- 246
- Citations by year
- 2026: 75 · 2025: 124 · 2024: 115 · 2023: 110 · 2022: 94 · 2021: 43 · 2020: 9
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cellular and Molecular Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Funders
- Onderzoeksraad, KU Leuven (C16/17/010)
- Fonds Wetenschappelijk Onderzoek (G.0808.18N)
- EC | Horizon 2020 Framework Programme (779295)
- Rega Foundation
- M.M. obtained a PhD fellowship supported by the L’Oréal-UNESCO for Women in Science initiative and the FWO-Vlaanderen
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- neutrophils, chemoattractant receptors, G protein-coupled receptors, atypical chemokine receptors, formyl peptides, anaphylatoxins, chemokines, neutrophil trafficking, neutrophil maturation, inflammation resolution, tissue repair, disease biomarkers, therapeutic target
- MeSH terms
- Animals, Chemotactic Factors, Disease, Health, Humans, Neutrophils, Signal Transduction, Receptors, Formyl Peptide
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