Neutrophil migration in infection and wound repair: going forward in reverse

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works

Neutrophil recruitment and function in health and inflammation

Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472 · see citing works

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992 · see citing works

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,382 · see citing works

Neutrophils and immunity: challenges and opportunities

Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971 · see citing works

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654 · see citing works

Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.

Collins, S. J., Ruscetti, F. W., Gallagher, R. E., & Gallo, R. C. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.5.2458 · Cited by 1,594 · see citing works

Neutrophils, from marrow to microbes.

Borregaard, N. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.011 · Cited by 1,550 · see citing works

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

Niethammer, P., Grabher, C., Look, A. T., & Mitchison, T. J. (2009) · Nature · doi:10.1038/nature08119 · Cited by 1,541 · see citing works

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210 · see citing works

Resolvin E1 and protectin D1 activate inflammation-resolution programmes

Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,188 · see citing works

Leukocyte Migration into Inflamed Tissues

Nourshargh, S., & Alon, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.008 · Cited by 1,172 · see citing works

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

Malaviya, R., Ikeda, T., Ross, E., & Abraham, S. N. (1996) · Nature · doi:10.1038/381077a0 · Cited by 1,123 · see citing works

Phagocyte partnership during the onset and resolution of inflammation

Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054 · see citing works

Mast cell-orchestrated immunity to pathogens

Abraham, S. N., & John, A. L. S. (2010) · Nature reviews. Immunology · doi:10.1038/nri2782 · Cited by 959 · see citing works

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Lämmermann, T., Afonso, P. V., Angermann, B., Wang, J. M., Kastenmüller, W., Parent, C. A., & Germain, R. N. (2013) · Nature · doi:10.1038/nature12175 · Cited by 937 · see citing works

ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors

Chen, Y., Corriden, R., Inoue, Y., Yip, L., Hashiguchi, N., Zinkernagel, A. S., Nizet, V., Insel, P. A., & JUNGER, W. G. (2006) · Science · doi:10.1126/science.1132559 · Cited by 858 · see citing works

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

Peters, N. C., Egen, J. G., Secundino, N. F. C., Debrabant, A., Kimblin, N., Kamhawi, S., Lawyer, P. G., Fay, M. P., Germain, R. N., & Sacks, D. L. (2008) · Science · doi:10.1126/science.1159194 · Cited by 837 · see citing works

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

Buckley, C. D., Gilroy, D. W., & Serhan, C. N. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.009 · Cited by 811 · see citing works

CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses

Chen, G.-Y., Tang, J., Zheng, P., & Liu, Y. (2009) · Science · doi:10.1126/science.1168988 · Cited by 786 · see citing works

Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

Middleton, J., Neil, S. J. D., Wintle, J., Clark‐Lewis, I., Moore, H. D., Lam, C., Auer, M., Hub, E., & Rot, A. (1997) · Cell · doi:10.1016/s0092-8674(00)80422-5 · Cited by 729 · see citing works

Pattern recognition receptors and control of adaptive immunity

Palm, N. W., & Medzhitov, R. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00731.x · Cited by 724 · see citing works

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Iyer, S. S., Pulskens, W. P., Sadler, J. J., Butter, L. M., Teske, G. J., Ulland, T. K., Eisenbarth, S. C., Florquin, S., Flavell, R. A., Leemans, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908698106 · Cited by 691 · see citing works

Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact

den Steen, P. E. V., Proost, P., Wuyts, A., Damme, J. V., & Opdenakker, G. (2000) · Blood · doi:10.1182/blood.v96.8.2673 · Cited by 680 · see citing works

DAMPs from Cell Death to New Life

Vénéreau, E., Ceriotti, C., & Bianchi, M. E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00422 · Cited by 666 · see citing works

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

Cacalano, G., Lee, J., Kikly, K. K., Ryan, A. M., Pitts-Meek, S., Hultgren, B., Wood, W. I., & Moore, M. W. (1994) · Science · doi:10.1126/science.8036519 · Cited by 663 · see citing works

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Krüger, P., Saffarzadeh, M., Weber, A. N. R., Rieber, N. P., Radsak, M. P., von Bernuth, H., Benarafa, C., Roos, D., Skokowa, J., & Hartl, D. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004651 · Cited by 663 · see citing works

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

Cho, J. S., Pietras, E. M., Garcia, N. C., Ramos, R. I., Farzam, D. M., Monroe, H. R., Magorien, J. E., Blauvelt, A., Kolls, J. K., Cheung, A. L., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40891 · Cited by 658 · see citing works

The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases

Russo, R. C., Garcia, C. C., Teixeira, M. M., & Amaral, F. A. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.894886 · Cited by 652 · see citing works

Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S., & Mócsai, A. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.06.034 · Cited by 642 · see citing works

The multifactorial role of neutrophils in rheumatoid arthritis

Wright, H. L., Moots, R. J., & Edwards, S. W. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.80 · Cited by 591 · see citing works

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

Woodfin, A., Voisin, M.-B., Beyrau, M., Colom, B., Caille, D., Diapouli, F.-M., Nash, G. B., Chavakis, T., Albelda, S. Μ., Rainger, G. E., et al. (2011) · Nature Immunology · doi:10.1038/ni.2062 · Cited by 590 · see citing works

Essential Role of Neutrophils in the Initiation and Progression of a Murine Model of Rheumatoid Arthritis

Wipke, B. T., & Allen, P. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1601 · Cited by 588 · see citing works

Chemokines and Their Receptors: Drug Targets in Immunity and Inflammation

Viola, A., & Luster, A. D. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.121806.154841 · Cited by 583 · see citing works

The resolution of inflammation

Buckley, C. D., Gilroy, D. W., Serhan, C. N., Stockinger, B., & Tak, P. P. (2012) · Nature reviews. Immunology · doi:10.1038/nri3362 · Cited by 580 · see citing works

Neutrophils cascading their way to inflammation

Sadik, C. D., Kim, N. D., & Luster, A. D. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.008 · Cited by 577 · see citing works

Sequential contribution of L- and P-selectin to leukocyte rolling in vivo.

Ley, K. F., Bullard, D. C., Arbonés, M. L., Bosse, R. C., Vestweber, D., Tedder, T. F., & Beaudet, A. L. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.669 · Cited by 574 · see citing works

Lipid Mediators in the Resolution of InflammationPreprint

Serhan, C. N., Chiang, N., Dalli, J., & Levy, B. D. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016311 · Cited by 545 · see citing works

The role of chemokines in neutrophil biology

Kobayashi, Y. (2007) · Frontiers in bioscience · doi:10.2741/2853 · Cited by 544 · see citing works

Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish

Mathias, J. R., Perrin, B. J., Liu, T.-X., Kanki, J. P., Look, A. T., & Anna Huttenlocher, A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0506346 · Cited by 532 · see citing works

Accelerated wound closure in neutrophil-depleted mice

Dovi, J. V., He, L.-K., & DiPietro, L. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802406 · Cited by 525 · see citing works

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

Cantin, A. M., Hartl, D., Konstan, M. W., & Chmiel, J. F. (2015) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2015.03.003 · Cited by 496 · see citing works

Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish

Lieschke, G. J., Oates, A. C., Crowhurst, M. O., Ward, A. C., & Layton, J. E. (2001) · Blood · doi:10.1182/blood.v98.10.3087 · Cited by 489 · see citing works

An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients

Heit, B., Tavener, S. A., Raharjo, E., & Kubes, P. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202114 · Cited by 487 · see citing works

P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac

Welch, H. C. E., Coadwell, W. J., Ellson, C. D., Ferguson, G. J., Andrews, S., Erdjument‐Bromage, H., Tempst, P., Hawkins, P. T., & Stephens, L. (2002) · Cell · doi:10.1016/s0092-8674(02)00663-3 · Cited by 481 · see citing works

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

Yoo, S. K., Starnes, T. W., Deng, Q., & Anna Huttenlocher, A. (2011) · Nature · doi:10.1038/nature10632 · Cited by 442 · see citing works

Delayed Wound Healing in CXCR2 Knockout Mice

Devalaraja, R. M., Nanney, L. B., Qian, Q., Du, J., Yu, Y., Devalaraja, M. N., & Richmond, A. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00034.x · Cited by 429 · see citing works

Social networking of human neutrophils within the immune system

Scapini, P., & Cassatella, M. A. (2014) · Blood · doi:10.1182/blood-2014-03-453217 · Cited by 407 · see citing works

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

Kreisel, D., Nava, R. G., Li, W., Zinselmeyer, B. H., Wang, B., Lai, J., Pless, R. B., Gelman, A. E., Krupnick, A. S., & Miller, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008737107 · Cited by 392 · see citing works

A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature.

Wong, J., Johnston, B., Lee, S. S., Bullard, D. C., Smith, C. W., Beaudet, A. L., & Kubes, P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119468 · Cited by 392 · see citing works

Dynamics of Neutrophil Migration in Lymph Nodes during Infection

Chtanova, T., Schaeffer, M., Han, S., van Dooren, G. G., Nöllmann, M., Herzmark, P., Chan, S. W., Satija, H., Camfield, K. A., Aaron, H. L., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.012 · Cited by 389 · see citing works

Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response

de Oliveira, S., Reyes‐Aldasoro, C. C., Candel, S., Renshaw, S. A., Mulero, V., & Calado, Â. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203266 · Cited by 385 · see citing works

Stabilized imaging of immune surveillance in the mouse lung

Looney, M. R., Thornton, E. E., Sen, D., Lamm, W. J., Glenny, R. W., & Krummel, M. F. (2010) · Nature Methods · doi:10.1038/nmeth.1543 · Cited by 364 · see citing works

Interleukin-17 and innate immunity in infections and chronic inflammation

Isailovic, N., Daigo, K., Mantovani, A., & Selmi, C. F. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.04.006 · Cited by 364 · see citing works

Interleukin-17 and its expanding biological functions

Xu, S., & Cao, X. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.21 · Cited by 358 · see citing works

Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes

Abadie, V., Badell, E., Douillard, P., Ensergueix, D., Leenen, P. J. M., Tanguy, M., Fiette, L., Saeland, S., Gicquel, B., & Winter, N. (2005) · Blood · doi:10.1182/blood-2005-03-1281 · Cited by 356 · see citing works

Live imaging reveals differing roles of macrophages and neutrophils during zebrafish tail fin regeneration

Li, L., Yan, B., Shi, Y.-Q., Zhang, W.-Q., & Wen, Z.-L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.349126 · Cited by 353 · see citing works

The regulation of cell motility and chemotaxis by phospholipid signaling

Kölsch, V., Charest, P. G., & Firtel, R. (2008) · Journal of Cell Science · doi:10.1242/jcs.023333 · Cited by 351 · see citing works

Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

Yoo, S. K., Deng, Q., Cavnar, P. J., Wu, Y., Hahn, K. M., & Anna Huttenlocher, A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.11.015 · Cited by 351 · see citing works

MyD88 Mediates Neutrophil Recruitment Initiated by IL-1R but Not TLR2 Activation in Immunity against Staphylococcus aureus

Miller, L. S., O’Connell, R. M., Gutiérrez, M. Á., Pietras, E. M., Shahangian, A., Gross, C. E., Thirumala, A., Cheung, A. L., Cheng, G., & Modlin, R. L. (2006) · Immunity · doi:10.1016/j.immuni.2005.11.011 · Cited by 348 · see citing works

LTB4 Is a Signal-Relay Molecule during Neutrophil Chemotaxis

Afonso, P. V., Janka-Junttila, M., Lee, Y. J., McCann, C., Oliver, C. M., Aamer, K. A., Losert, W., Cicerone, M. T., & Parent, C. A. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.02.003 · Cited by 346 · see citing works

Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity

Carmona‐Rivera, C., & Kaplan, M. J. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0375-7 · Cited by 343 · see citing works

Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis

Chou, R. C., Kim, N. D., Sadik, C. D., Seung, E., Lan, Y., Byrne, M. H., Haribabu, B., Iwakura, Y., & Luster, A. D. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.018 · Cited by 342 · see citing works

Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration

Buckley, C. D., Ross, E. A., McGettrick, H. M., Osborne, C., Haworth, O., Schmutz, C., Stone, P. C., Salmon, M., Matharu, N. M., Vohra, R. K., et al. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0905496 · Cited by 340 · see citing works

Resolution phase lipid mediators of inflammation: agonists of resolution

Serhan, C. N., & Chiang, N. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.05.012 · Cited by 332 · see citing works

Safety and efficacy of a CXCR 2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo‐controlled clinical trial

Nair, P. K., Gaga, M., Ζervas, Ε., Alagha, K., Hargreave, F. E., O’Byrne, P. M., Stryszak, P., Gann, L., Sadeh, J., Chanez, P., et al. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.04014.x · Cited by 332 · see citing works

Inflammasome-Mediated Production of IL-1β Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo

Miller, L. S., Pietras, E. M., Uricchio, L. H., Hirano, K., Rao, S. S. D., Lin, H., O’Connell, R. M., Iwakura, Y., Cheung, A. L., Cheng, G., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6933 · Cited by 325 · see citing works

Chemokine receptor antagonists: overcoming developmental hurdles

Horuk, R. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2734 · Cited by 302 · see citing works

Spleen Tyrosine Kinase Syk Is Necessary for E-Selectin-Induced αLβ2 Integrin-Mediated Rolling on Intercellular Adhesion Molecule-1

Zarbock, A., Lowell, C. A., & Ley, K. F. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.011 · Cited by 292 · see citing works

Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection

Abtin, A., Jain, R., Mitchell, A. J., Roediger, B., Brzoska, A. J., Tikoo, S., Cheng, Q., Ng, L. G., Cavanagh, L. L., von Andrian, U. H., et al. (2013) · Nature Immunology · doi:10.1038/ni.2769 · Cited by 291 · see citing works

Neutrophil-derived leukotriene B4 is required for inflammatory arthritis

Chen, M., LAM, B. K., Kanaoka, Y., Nigrovic, P. A., Audoly, L., Austen, K. F., & Lee, D. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052371 · Cited by 285 · see citing works

Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass

Weiner, O. D. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00310-1 · Cited by 284 · see citing works

Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

Shimada, T., Park, B. G., Wolf, A. J., Brikos, C., Goodridge, H. S., Becker, C. A., Reyes, C. N., Miao, E. A., Aderem, A., Götz, F., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2009.12.008 · Cited by 274 · see citing works

Innate Immune Functions of Immature Neutrophils in Patients With Sepsis and Severe Systemic Inflammatory Response Syndrome*

Drifte, G., Dunn-Siegrist, I., Tissières, P., & Pugin, J. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e318274647d · Cited by 273 · see citing works

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo

Colom, B., Bodkin, J. V., Beyrau, M., Woodfin, A., Ody, C., Rourke, C., Chavakis, T., Brohi, K., Imhof, B. A., & Nourshargh, S. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.010 · Cited by 271 · see citing works

The role of transcription-independent damage signals in the initiation of epithelial wound healing

Cordeiro, J. V., & Jacinto, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3541 · Cited by 271 · see citing works

Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway

Bowers, N. L., Helton, E. S., Huijbregts, R. P. H., Goepfert, P., Heath, S. L., & Hel, Z. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003993 · Cited by 256 · see citing works

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

Dalli, J., Winkler, J. W., Colas, R. A., Arnardottir, H. H., Cheng, C.-Y. C., Chiang, N., Petasis, N. A., & Serhan, C. N. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.11.010 · Cited by 246 · see citing works

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism

Robertson, A. L., Holmes, G. R., Bojarczuk, A., Burgon, J., Loynes, C. A., Chimen, M., Sawtell, A. K., Hamza, B. M., Willson, J. A., Walmsley, S. R., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007672 · Cited by 243 · see citing works

Integration of inflammatory signals by rolling neutrophils

Ley, K. F. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18602.x · Cited by 242 · see citing works

Damage-Associated Molecular Patterns Control Neutrophil Recruitment

Pittman, K., & Kubes, P. (2013) · Journal of Innate Immunity · doi:10.1159/000347132 · Cited by 241 · see citing works

Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

Elks, P. M., van Eeden, F. J., Dixon, G., Wang, X., Reyes‐Aldasoro, C. C., Ingham, P. W., Whyte, M. K. B., Walmsley, S. R., & Renshaw, S. A. (2011) · Blood · doi:10.1182/blood-2010-12-324186 · Cited by 240 · see citing works

Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium

Schiwon, M., Weisheit, C. K., Franken, L., Gutweiler, S., Dixit, A., Meyer‐Schwesinger, C., Pohl, J., Maurice, N. J., Thiebes, S., Lorenz, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.006 · Cited by 238 · see citing works

Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases

Hartl, D., Krauss‐Etschmann, S., Koller, B., Hordijk, P. L., Kuijpers, T. W., Hoffmann, F., Hector, A., Eber, E., Marcos, V., Bittmann, I., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.8053 · Cited by 235 · see citing works

Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor.

Lindley, I. J. D., Aschauer, H. N., SEIFERT, J. ‐., Lam, C., Brunowsky, W., Kownatzki, E., Thelen, M., Peveri, P., Dewald, B., & Tscharner, V. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9199 · Cited by 231 · see citing works

Characterization of a new human diploid myeloid leukemia cell line (PLB- 985) with granulocytic and monocytic differentiating capacity

Tucker, K., Lilly, M., Heck, L. J., & Rado, T. (1987) · Blood · doi:10.1182/blood.v70.2.372.372 · Cited by 227 · see citing works

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity

Beyrau, M., Bodkin, J. V., & Nourshargh, S. (2012) · Open Biology · doi:10.1098/rsob.120134 · Cited by 223 · see citing works

Colchicine in clinical medicine. A guide for internists

Cocco, G., Chu, D. C. C., & Pandolfi, S. (2010) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2010.09.010 · Cited by 222 · see citing works

Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation

Sadik, C. D., & Luster, A. D. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0811402 · Cited by 219 · see citing works

Visualizing the Neutrophil Response to Sterile Tissue Injury in Mouse Dermis Reveals a Three-Phase Cascade of Events

Ng, L. G., Qin, J., Roediger, B., Wang, Y., Jain, R., Cavanagh, L. L., Smith, A. L., Jones, C., de Veer, M., Grimbaldeston, M. A., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.179 · Cited by 218 · see citing works

Leukocyte migration in the interstitial space of non-lymphoid organs

Weninger, W., Biro, M., & Jain, R. (2014) · Nature reviews. Immunology · doi:10.1038/nri3641 · Cited by 215 · see citing works

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

Kunisaki, Y., Nishikimi, A., Tanaka, Y., Takii, R., Noda, M., Inayoshi, A., Watanabe, K., Sanematsu, F., Sasazuki, T., Sasaki, T., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602142 · Cited by 214 · see citing works

Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes

Hampton, H. R., Bailey, J., Tomura, M., Brink, R., & Chtanova, T. (2015) · Nature Communications · doi:10.1038/ncomms8139 · Cited by 211 · see citing works

LPS Responsiveness and Neutrophil Chemotaxis In Vivo Require PMN MMP-8 Activity

Tester, A. M., Cox, J. H., Connor, A. R., Starr, A. E., Dean, R. A., Puente, X. S., López-Otı́n, C., & Overall, C. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000312 · Cited by 210 · see citing works

Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis

Malaviya, R., & Abraham, S. N. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.6.841 · Cited by 209 · see citing works

Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells

Matsushima, H., Geng, S., Lu, R., Okamoto, T., Yao, Y., Mayuzumi, N., Kotol, P. F., Chojnacki, B. J., Miyazaki, T., Gallo, R. L., et al. (2013) · Blood · doi:10.1182/blood-2012-07-445189 · Cited by 207 · see citing works

The murine IL-8 homologues KC, MIP-2, and LIX are found in endothelial cytoplasmic granules but not in Weibel-Palade bodies

Fosse, J. H., Wilhelmsen, L., & Haraldsen, G. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809532 · Cited by 205 · see citing works

Induction of a Selective and Persistent Extravasation of Neutrophils into the Peritoneal Cavity by Tryptase Mouse Mast Cell Protease 6

Huang, C. B., Friend, D. S., Qiu, W.-T., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.4.1910 · Cited by 200 · see citing works

Prioritization of Competing Damage and Developmental Signals by Migrating Macrophages in the Drosophila Embryo

Moreira, S., Stramer, B. M., Evans, I. R., Wood, W., & Martin, P. B. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.047 · Cited by 194 · see citing works

Role of G protein-coupled receptors in inflammation

Sun, L., & Ye, R. D. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.200 · Cited by 192 · see citing works

Current theories on the pathophysiology of multiple organ failure after trauma

Tsukamoto, T., Chanthaphavong, R. S., & Pape, H. (2009) · Injury · doi:10.1016/j.injury.2009.07.010 · Cited by 183 · see citing works

Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury

Eickmeier, O., Seki, H., Haworth, O., Hilberath, J. N., Gao, F., Uddin, M., Croze, R. H., Carlo, T., Pfeffer, M. A., & Levy, B. D. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.66 · Cited by 181 · see citing works

The participation of plasma membrane hemichannels to purinergic signaling

Baroja‐Mazo, A., Barberà-Cremades, M., & Pelegrı́n, P. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.01.002 · Cited by 173 · see citing works

Innate and adaptive immune responses against Staphylococcus aureus skin infections

Krishna, S. M., & Miller, L. S. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0292-6 · Cited by 166 · see citing works

Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

Duffy, D., Perrin, H., Abadie, V., Benhabilès, N., Boissonnas, A., Liard, C., Descours, B., Reboulleau, D., Bonduelle, O., Verrier, B., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.07.015 · Cited by 166 · see citing works

Intracellular signalling during neutrophil recruitment

Mócsai, A., Walzog, B., & Lowell, C. A. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv159 · Cited by 160 · see citing works

Neutrophil-Regulatory Tn Lymphocytes

Ley, K. F., Smith, E. E., & Stark, M. A. (2006) · Immunologic Research · doi:10.1385/ir:34:3:229 · Cited by 158 · see citing works

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

Walters, K., Green, J. M., Surfus, J. C., Yoo, S. K., & Anna Huttenlocher, A. (2010) · Blood · doi:10.1182/blood-2010-03-276972 · Cited by 155 · see citing works

Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways

Tirouvanziam, R. M., Gernez, Y., Conrad, C., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712386105 · Cited by 150 · see citing works

The Chemokine Receptors CXCR1 and CXCR2 Couple to Distinct G Protein-Coupled Receptor Kinases To Mediate and Regulate Leukocyte Functions

Raghuwanshi, S. K., Su, Y., Singh, V., Haynes, K., Richmond, A. J., & Richardson, R. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201114 · Cited by 150 · see citing works

Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish

Yoo, S. K., & Anna Huttenlocher, A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1010567 · Cited by 149 · see citing works

Role of Neutrophil Leukocytes in Cutaneous Infection Caused byStaphylococcus aureus

Mölne, L., Verdrengh, M., & Tarkowski, A. (2000) · Infection and Immunity · doi:10.1128/iai.68.11.6162-6167.2000 · Cited by 148 · see citing works

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns

Liu, Y., Chen, G.-Y., & Zheng, P. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.09.006 · Cited by 147 · see citing works

Dual Roles for Rac2 in Neutrophil Motility and Active Retention in Zebrafish Hematopoietic Tissue

Deng, Q., Yoo, S. K., Cavnar, P. J., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.013 · Cited by 146 · see citing works

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

Kovács, M., Németh, T., Jakus, Z., Sitaru, C., Simon, E., Futosi, K., Botz, B., Helyes, Z., Lowell, C. A., & Mócsai, A. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20132496 · Cited by 146 · see citing works

Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients

Sarris, M., Masson, J., Maurin, D., van der Aa, L. M., Boudinot, P., Lortat‐Jacob, H., & Herbomel, P. (2012) · Current Biology · doi:10.1016/j.cub.2012.11.018 · Cited by 145 · see citing works

Zebrafish as a model for the study of neutrophil biology

Henry, K. M., Loynes, C. A., Whyte, M. K. B., & Renshaw, S. A. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1112594 · Cited by 143 · see citing works

SB‐656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone‐induced airway inflammation in humans

Lazaar, A. L., Sweeney, L. E., MacDonald, A. J., et al. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.03968.x · Cited by 142 · see citing works

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

Bao, Y., Ledderose, C., Graf, A. F., Brix, B., Birsak, T., Lee, A., Zhang, J., & JUNGER, W. G. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201503066 · Cited by 141 · see citing works

Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor

Powell, W. S., Gravel, S., Macleod, J., Mills, E. L., & Hashefi, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98347-x · Cited by 139 · see citing works

Presence of neutrophil-bearing antigen in lymphoid organs of immune mice

Maletto, B. A., Ropolo, A. S., Alignani, D., Liscovsky, M. V., Ranocchia, R. P., Morón, V. G., & Pistoresi-Palencia, M. C. (2006) · Blood · doi:10.1182/blood-2006-04-016659 · Cited by 139 · see citing works

Interleukin-12 Promotes Gamma Interferon-Dependent Neutrophil Recruitment in the Lung and Improves Protection against Respiratory Streptococcus pneumoniae Infection

Sun, K., Salmon, S. L., Lotz, S. A., et al. (2007) · Infection and Immunity · doi:10.1128/iai.01403-06 · Cited by 139 · see citing works

Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration

Tauzin, S., Starnes, T. W., Barros-Becker, F., Lam, P., & Anna Huttenlocher, A. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201408090 · Cited by 137 · see citing works

Hydrogen peroxide-induced chemotaxis of mouse peritoneal neutrophils.

Klyubin, I. V., Kirpichnikova, K. M., & Gamaley, I. A. (1996) · PubMed · Cited by 137 · see citing works

The sweet spot: how GAGs help chemokines guide migrating cells

Monneau, Y. R., Arenzana‐Seisdedos, F., & Lortat‐Jacob, H. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0915-440r · Cited by 136 · see citing works

Imaging the dynamic platelet‐neutrophil response in sterile liver injury and repair in mice

Slaba, I., Wang, J., Kołaczkowska, E., McDonald, B., Lee, W., & Kubes, P. (2015) · Hepatology · doi:10.1002/hep.28003 · Cited by 135 · see citing works

Tissue damage detection by osmotic surveillance

Enyedi, B., Kala, S., Nikolich‐Zugich, T., & Niethammer, P. (2013) · Nature Cell Biology · doi:10.1038/ncb2818 · Cited by 128 · see citing works

Neutrophils in host defense: new insights from zebrafish

Harvie, E. A., & Anna Huttenlocher, A. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr1114-524r · Cited by 125 · see citing works

Mitochondrial Peptides Are Potent Immune Activators That Activate Human Neutrophils Via FPR-1

Raoof, M., Zhang, Q., Itagaki, K., & Hauser, C. J. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181dcd28d · Cited by 124 · see citing works

Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo

Tharp, W. G., Yadav, R., Irimia, D., Upadhyaya, A., Samadani, A., Hurtado, O., Liu, S. Y., Munisamy, S., Brainard, D. M., Mahon, M. J., et al. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0905516 · Cited by 123 · see citing works

TLR Cross-talk Confers Specificity to Innate Immunity

Tan, R. S. T., Ho, B., Leung, B. P. L., & Ding, J. L. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.921164 · Cited by 122 · see citing works

Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils

Bauer, S., Abdgawad, M., Gunnarsson, L., Segelmark, M., Tapper, H., & Hellmark, T. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0806514 · Cited by 122 · see citing works

Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish

Pase, L., Layton, J. E., Wittmann, C., Ellett, F., Nowell, C. J., Reyes-Aldasoro, C. C., Varma, S., Rogers, K. L., Hall, C. J., Keightley, M. C., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.060 · Cited by 118 · see citing works

P2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation

Lecut, C., Frederix, K., Johnson, D. M., Deroanne, C., Thiry, M., Faccinetto, C., Marée, R., Evans, R. J., Volders, P. G. A., Bours, V., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804007 · Cited by 112 · see citing works

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

Moss, R. B., Mistry, S. J., Konstan, M. W., et al. (2012) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2012.08.016 · Cited by 111 · see citing works

The Human Neutrophil Subsets Defined by the Presence or Absence of OLFM4 Both Transmigrate into Tissue In Vivo and Give Rise to Distinct NETs In Vitro

Welin, A., Amirbeagi, F., Christenson, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069575 · Cited by 109 · see citing works

Microfluidic platform for the quantitative analysis of leukocyte migration signatures

Boneschansker, L., Yan, J., Wong, E. A., Briscoe, D. M., & Irimia, D. (2014) · Nature Communications · doi:10.1038/ncomms5787 · Cited by 108 · see citing works

In the eye of the neutrophil swarm—navigation signals that bring neutrophils together in inflamed and infected tissues

Lämmermann, T. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.1mr0915-403 · Cited by 108 · see citing works

Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish

Deng, Q., Sarris, M., Bennin, D. A., Green, J. M., Herbomel, P., & Anna Huttenlocher, A. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012534 · Cited by 105 · see citing works

The Role of Interleukin-17 in the Helicobacter pylori Induced Infection and Immunity

Kabir, S. (2011) · Helicobacter · doi:10.1111/j.1523-5378.2010.00812.x · Cited by 99 · see citing works

The Use of Spinning-Disk Confocal Microscopy for the Intravital Analysis of Platelet Dynamics in Response to Systemic and Local Inflammation

Jenne, C. N., Wong, C. H. Y., Petri, B., & Kubes, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025109 · Cited by 94 · see citing works

Il-1β and Reactive Oxygen Species Differentially Regulate Neutrophil Directional Migration and Basal Random Motility in a Zebrafish Injury–Induced Inflammation Model

Yan, B., Han, P., Pan, L., Lü, W., Xiong, J., Zhang, M., Zhang, W., Li, L., & Wen, Z. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301645 · Cited by 92 · see citing works

Pharmacological Characterization of AZD5069, a Slowly Reversible CXC Chemokine Receptor 2 Antagonist

Nicholls, D., Wiley, K. E., Dainty, I. A., MacIntosh, F., Phillips, C., Gaw, A. J., & Mårdh, C. K. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.221358 · Cited by 92 · see citing works

Th17 cells: critical mediators of host responses to burn injury and sepsis

Rendón, J. L., & Choudhry, M. A. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212083 · Cited by 92 · see citing works

Siglec-G/10 in self-nonself discrimination of innate and adaptive immunity

Chen, G.-Y., Brown, N. K., Zheng, P., & Liu, Y. (2014) · Glycobiology · doi:10.1093/glycob/cwu068 · Cited by 90 · see citing works

Neutrophil fate in experimental glomerular capillary injury in the rat. Emigration exceeds in situ clearance by apoptosis.

Hughes, J., Johnson, R. J., Mooney, A. F., Hugo, C., GORDON, K. L., & Savill, J. (1997) · Europe PMC (PubMed Central) · Cited by 89 · see citing works

Molecular players in neutrophil chemotaxis—focus on PI3K and small GTPases

Gambardella, L., & Vermeren, S. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1112564 · Cited by 84 · see citing works

N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways

Hazeldine, J., Hampson, P., Opoku, F., Foster, M., & Lord, J. M. (2015) · Injury · doi:10.1016/j.injury.2015.03.028 · Cited by 81 · see citing works

ATP Modulates Acute Inflammation In Vivo through Dual Oxidase 1–Derived H2O2 Production and NF-κB Activation

de Oliveira, S., López‐Muñoz, A., Candel, S., Pelegrı́n, P., Calado, Â., & Mulero, V. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302902 · Cited by 81 · see citing works

Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury

Wu, D., Zeng, Y., Fan, Y., Wu, J., Mulatibieke, T., Ni, J., Yu, G., Wan, R., Wang, X., & Hu, G. (2016) · Scientific Reports · doi:10.1038/srep20545 · Cited by 81 · see citing works

Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury

Deng, Q., Harvie, E. A., & Anna Huttenlocher, A. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01738.x · Cited by 79 · see citing works

Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges

Montanez-Sauri, S. I., Beebe, D. J., & Sung, K. E. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1738-5 · Cited by 79 · see citing works

Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

Leaker, B. R., Barnes, P. J., & O'Connor, B. J. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-137 · Cited by 79 · see citing works

Inflammation and repeated infections in CGD: two sides of a coin

Kuijpers, T. W., & Lutter, R. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0834-z · Cited by 77 · see citing works

Neutrophils come of age in chronic inflammation

Caielli, S., Banchereau, J., & Pascual, V. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.09.008 · Cited by 77 · see citing works

Intravital two-photon microscopy of host-pathogen interactions in a mouse model ofStaphylococcus aureusskin abscess formation

Liese, J., Rooijakkers, S. H. M., van Strijp, J. A. G., Novick, R. P., & Dustin, M. L. (2012) · Cellular Microbiology · doi:10.1111/cmi.12085 · Cited by 75 · see citing works

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non‐competitive allosteric inhibitor

Bertini, R., Barcelos, L. S., Beccari, A., Cavalieri, B., Moriconi, A., Bizzarri, C., Benedetto, P. D., Giacinto, C. D., Gloaguen, I., Galliera, E., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01566.x · Cited by 75 · see citing works

Defining the phenotype of neutrophils following reverse migration in zebrafish

Ellett, F. E., Elks, P. M., Robertson, A. L., Ogryzko, N. V., & Renshaw, S. A. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ma0315-105r · Cited by 74 · see citing works

Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices

Afonso, P. V., McCann, C., Kapnick, S. M., & Parent, C. A. (2012) · Blood · doi:10.1182/blood-2012-08-451575 · Cited by 73 · see citing works

Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels

Hamza, B. M., Wong, E. A., Patel, S. H., Cho, H., Martel, J., & Irimia, D. (2013) · Integrative Biology · doi:10.1039/c3ib40175h · Cited by 73 · see citing works

Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages

Hall, C. J., Flores, M. V., Chien, A., Davidson, A. J., Crosier, K. E., & Crosier, P. S. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0708405 · Cited by 73 · see citing works

Parallel Phosphatidylinositol 3-Kinase (PI3K)-dependent and Src-dependent Pathways Lead to CXCL8-mediated Rac2 Activation and Chemotaxis

Sai, J., Raman, D., Liu, Y., Wikswo, J. P., & Richmond, A. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805611200 · Cited by 72 · see citing works

New development in studies of formyl-peptide receptors: critical roles in host defense

Li, L., Chen, K., Xiang, Y., Yoshimura, T., Su, S., Zhu, J., Bian, X., & Wang, J. M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ri0815-354rr · Cited by 72 · see citing works

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions

Jurčević, S., Humfrey, C. D. N., Uddin, M., Warrington, S., LARSSON, B. S., & Keen, C. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12724 · Cited by 71 · see citing works

Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration

Kukulski, F., Yebdri, F. B., Lecka, J., Kauffenstein, G., Lévesque, S. A., Martı́n-Satué, M., & Sévigny, J. (2009) · Cytokine · doi:10.1016/j.cyto.2009.02.011 · Cited by 68 · see citing works

An arrayed high-content chemotaxis assay for patient diagnosis

Berthier, E., Surfus, J. C., Verbsky, J. W., Anna Huttenlocher, A., & Beebe, D. J. (2010) · Integrative Biology · doi:10.1039/c0ib00030b · Cited by 68 · see citing works

Characterization of a Novel Chemokine-Containing Storage Granule in Endothelial Cells: Evidence for Preferential Exocytosis Mediated by Protein Kinase A and Diacylglycerol

Øynebråten, I., Barois, N., Hagelsteen, K., Johansen, F., Bakke, O., & Haraldsen, G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5358 · Cited by 66 · see citing works

Self-organization of protrusions and polarity during eukaryotic chemotaxis

Graziano, B. R., & Weiner, O. D. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.06.007 · Cited by 66 · see citing works

Whole blood human neutrophil trafficking in a microfluidic model of infection and inflammation

Hamza, B. M., & Irimia, D. (2015) · Lab on a Chip · doi:10.1039/c5lc00245a · Cited by 65 · see citing works

Fugetaxis: active movement of leukocytes away from a chemokinetic agent

Vianello, F., Olszak, I. T., & Poznansky, M. C. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0675-z · Cited by 64 · see citing works

Low-Volume Toolbox for the Discovery of Immunosuppressive Fungal Secondary Metabolites

Berthier, E., Lim, F. Y., Deng, Q., Guo, C.-J., Kontoyiannis, D. P., Wang, C. C. C., Rindy, J., Beebe, D. J., Huttenlocher, A., & Keller, N. P. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003289 · Cited by 63 · see citing works

VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis

Neel, N. F., Barzik, M., Raman, D., et al. (2009) · Journal of Cell Science · doi:10.1242/jcs.039057 · Cited by 62 · see citing works

The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) − a selective CXCR2 antagonist − in healthy adult subjects

Miller, B. E., Mistry, S. J., Smart, K. A., et al. (2015) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-015-0017-x · Cited by 60 · see citing works

Microbe- and danger-induced inflammation

Broggi, A., & Granucci, F. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.06.037 · Cited by 60 · see citing works

Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients

Cloke, T., Munder, M., Bergin, P. J., Herath, S., Modolell, M., Taylor, G. P., Müller, I., & Kropf, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072034 · Cited by 55 · see citing works

Bacteria-induced phagocyte secondary necrosis as a pathogenicity mechanism

Silva, M. T. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0410205 · Cited by 55 · see citing works

Neutrophil Reverse Migration Becomes Transparent with Zebrafish

Starnes, T. W., & Anna Huttenlocher, A. (2012) · Advances in Hematology · doi:10.1155/2012/398640 · Cited by 54 · see citing works

A pilot study on reparixin, a CXCR1/2 antagonist, to assess safety and efficacy in attenuating ischaemia–reperfusion injury and inflammation after on-pump coronary artery bypass graft surgery

Opfermann, P. L., Derhaschnig, U., Felli, A., Wenisch, J. M., Santer, D., Zuckermann, A. O., Dworschak, M., Jilma, B., & Steinlechner, B. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12488 · Cited by 52 · see citing works

Leukocyte migration from a fish eye's view

Deng, Q., & Anna Huttenlocher, A. (2012) · Journal of Cell Science · doi:10.1242/jcs.093633 · Cited by 52 · see citing works

Differential Expression of Granulopoiesis Related Genes in Neutrophil Subsets Distinguished by Membrane Expression of CD177

Hu, N., Mora-Jensen, H. I., Theilgaard‐Mönch, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099671 · Cited by 51 · see citing works

In Vivo Imaging of Corneal Inflammation: New Tools for Clinical Practice and Research

Mantopoulos, D., Cruzat, A., & Hamrah, P. (2010) · Seminars in Ophthalmology · doi:10.3109/08820538.2010.518542 · Cited by 47 · see citing works

Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux

Beerman, R. W., Matty, M. A., Au, G. G., Looger, L. L., Choudhury, K. R., Keller, P., & Tobin, D. M. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.11.010 · Cited by 47 · see citing works

Toll-Like Receptor 9 Signaling in Dendritic Cells Regulates Neutrophil Recruitment to Inflammatory Foci following Leishmania infantum Infection

Sacramento, L. A., Trevelin, S. C., Nascimento, M. S. L., et al. (2015) · Infection and Immunity · doi:10.1128/iai.00975-15 · Cited by 44 · see citing works

Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling

Holmes, G. R., Anderson, S., Dixon, G., Robertson, A. L., Reyes‐Aldasoro, C. C., Billings, S. A., Renshaw, S. A., & Kadirkamanathan, V. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0542 · Cited by 40 · see citing works

Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D

Yamahashi, Y., Cavnar, P. J., Hind, L. E., et al. (2015) · Biomedical Microdevices · doi:10.1007/s10544-015-9998-x · Cited by 37 · see citing works

Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model

Holmes, G. R., Dixon, G., Anderson, S., Reyes‐Aldasoro, C. C., Elks, P. M., Billings, S. A., Whyte, M. K. B., Kadirkamanathan, V., & Renshaw, S. A. (2012) · Advances in Hematology · doi:10.1155/2012/792163 · Cited by 30 · see citing works

PI3K and Chemotaxis: A Priming Issue?

Afonso, P. V., & Parent, C. A. (2011) · Science Signaling · doi:10.1126/scisignal.2002019 · Cited by 29 · see citing works

The Sbi Protein Contributes to Staphylococcus aureus Inflammatory Response during Systemic Infection

Gonzalez, C. D., Ledo, C., Giai, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131879 · Cited by 27 · see citing works

Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitment

Baker, M. J., Pan, D., & Welch, H. C. E. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000199 · Cited by 27 · see citing works

Role of the Yersinia YopJ protein in suppressing interleukin-8 secretion by human polymorphonuclear leukocytes

Spinner, J. L., Hasenkrug, A. M., Shannon, J. G., et al. (2015) · Microbes and Infection · doi:10.1016/j.micinf.2015.08.015 · Cited by 26 · see citing works

Isolation of healthy individuals' and rheumatoid arthritis patients' peripheral blood neutrophils by the gelatin and Ficoll-Hypaque methods: Comparative efficiency and impact on the neutrophil oxidative metabolism and Fcγ receptor expression

Paoliello-Paschoalato, A. B., Azzolini, A. E. C. S., Cruz, M. F. C., Marchi, L. F., Kabeya, L. M., Donadi, E. A., & Lucisano-Valim, Y. M. (2014) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.07.001 · Cited by 22 · see citing works

Imaging Neutrophils and Monocytes in Mesenteric Veins by Intravital Microscopy on Anaesthetized Mice in Real Time

Emre, Y., Jemelin, S., & Imhof, B. A. (2015) · Journal of Visualized Experiments · doi:10.3791/53314 · Cited by 7 · see citing works

Immunology of Wound Healing

Ellis, S., Lin, E. J., & Tartar, D. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0234-9 · Cited by 625 · see citing works

Neutrophil chemoattractant receptors in health and disease: Double-edged swords

Metzemaekers, M., Gouwy, M., & Proost, P. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0412-0 · Cited by 570 · see citing works

Dual-responsive biohybrid neutrobots for active target delivery

Zhang, H., Li, Z., Gao, C., Fan, X., Pang, Y., Li, T., Wu, Z., Xie, H., & He, Q. (2021) · Science Robotics · doi:10.1126/scirobotics.aaz9519 · Cited by 518 · see citing works

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

Si, L., Bai, H., Rodas, M., Cao, W., Oh, C. Y., Jiang, A., Moller, R., Hoagland, D., Oishi, K., Horiuchi, S., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00718-9 · Cited by 440 · see citing works

Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease

Prame Kumar, K., Nicholls, A. J., & Wong, C. H. Y. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2753-2 · Cited by 417 · see citing works

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396 · see citing works

Microbes and Cancer

Dzutsev, A., Badger, J. H., Perez-Chanona, E., Roy, S., Salcedo, R., Smith, C. K., & Trinchieri, G. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052133 · Cited by 302 · see citing works

Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing

Garg, A. D., Vandenberk, L., Fang, S., Fasche, T., Van Eygen, S., Maes, J., Van Woensel, M., Koks, C., Vanthillo, N., Graf, N., et al. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.15 · Cited by 120 · see citing works

Role of Neutrophils in the Pathogenesis of Nonalcoholic Steatohepatitis

Hwang, S., Yun, H., Moon, S., Cho, Y. E., & Gao, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.751802 · Cited by 84 · see citing works

T‐Cell Immunoglobulin and Mucin Domain‐Containing Protein‐4 Is Critical for Kupffer Cell Homeostatic Function in the Activation and Resolution of Liver Ischemia Reperfusion Injury

Ni, M., Zhang, J., Sosa, R., Zhang, H., Wang, H., Jin, D., Crowley, K., Naini, B., Reed, F. E., Busuttil, R. W., et al. (2021) · Hepatology · doi:10.1002/hep.31906 · Cited by 80 · see citing works

The role of the host—Neutrophil biology

Chapple, I. L. C., Hirschfeld, J., Kantarci, A., Wilensky, A., & Shapira, L. (2023) · Periodontology 2000 · doi:10.1111/prd.12490 · Cited by 83 · see citing works

Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins

Schröter, J., & Schiller, J. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8386362 · Cited by 51 · see citing works

Physical cues in biomaterials modulate macrophage polarization for bone regeneration: a review

Yang, T., Fang, Z., Zhang, J., & Zheng, S. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1640560 · Cited by 50 · see citing works

Microalgae <i>Schizochytrium</i> sp. as a source of docosahexaenoic acid (DHA): Effects on diet digestibility, oxidation and palatability and on immunity and inflammatory indices in dogs

Souza, C. M. M., de Lima, D. C., Bastos, T. S., de Oliveira, S. G., Beirão, B. C. B., & Félix, A. P. (2019) · Animal Science Journal · doi:10.1111/asj.13294 · Cited by 31 · see citing works

Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast

Scherer, A. K., Blair, B. A., Park, J., Seman, B. G., Kelley, J. B., & Wheeler, R. T. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008414 · Cited by 30 · see citing works

The Role of Snake Venom Proteins in Inducing Inflammation Post-Envenomation: An Overview on Mechanistic Insights and Treatment Strategies

Rao, S., Reghu, N., Nair, B. G., & Vanuopadath, M. (2024) · Toxins · doi:10.3390/toxins16120519 · Cited by 30 · see citing works

A novel rapid Neutrophil Extracellular Trap (NET) release mechanism without neutrophil death

Kubes⁎, P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.097

Neutrophil elastase‐deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

Martinod, K., Witsch, T., Farley, K., Gallant, M., Remold‐O'Donnell, E., & Wagner, D. D. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13239 · Cited by 188 · see citing works

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation

Arends, E. J., van Dam, L. S., Kraaij, T., et al. (2019) · Journal of Visualized Experiments · doi:10.3791/59150-v · Cited by 4 · see citing works

Evaluation of Circulating Markers of Neutrophil Extracellular Trap (NET) Formation as Risk Factors for Diabetic Retinopathy in a Case-Control Association Study

Park, J. H., Kim, J. E., Gu, J. Y., et al. (2016) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0042-101792 · Cited by 54 · see citing works

Quantification of Neutrophil Extracellular Trap (NET)Formation in Healthy Subjects

Riyapa, D. (2018) · Warasan Theknik Kanphaet