Increased immune escape of the new SARS-CoV-2 variant of concern Omicron
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Omicron BA.1 possesses a greater capacity of immune escape.
“This is different with Omicron BA.1 which possesses a greater capacity of immune escape [29-31];”
From Vaccine effectiveness and duration of protection of COVID-19 mRNA vaccines against Delta and Omicron BA.1 symptomatic and severe COVID-19 outcomes in adults aged 50 years and over in France (2023) · cites this paper as [30]
In the main text (pp. 293–295), the authors report markedly reduced neutralization of Omicron compared with D614G, supporting greater immune escape. Our copy calls the tested variant Omicron or B.1.1.529, but does not identify it as BA.1, so the BA.1-specific attribution is not established. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
Planas, D., Veyer, D., Baidaliuk, A., Staropoli, I., Guivel-Benhassine, F., Rajah, M. M., Planchais, C., Porrot, F., Robillard, N., Puech, J., et al. (2021) · Nature · doi:10.1038/s41586-021-03777-9 · Cited by 1,992 · see citing works
Spike mutation D614G alters SARS-CoV-2 fitness
Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., et al. (2021) · Nature · doi:10.1038/s41586-020-2895-3 · Cited by 1,558 · see citing works
Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2
Liu, L., Iketani, S., Guo, Y., Chan, J. F.-W., Wang, M., Liu, L., Luo, Y., Chu, H., Huang, Y., Nair, M. S., et al. (2022) · Nature · doi:10.1038/s41586-021-04388-0 · Cited by 1,290 · see citing works
Liu, Z., VanBlargan, L. A., Bloyet, L.-M., Rothlauf, P. W., Chen, R. E., Stumpf, S., Zhao, H., Errico, J. M., Theel, E. S., Liebeskind, M. J., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.01.014 · Cited by 725 · see citing works
The N501Y spike substitution enhances SARS-CoV-2 infection and transmission
Liu, Y., Liu, J., Plante, K. S., Plante, J. A., Xie, X., Zhang, X., Ku, Z., An, Z., Scharton, D., Schindewolf, C., et al. (2021) · Nature · doi:10.1038/s41586-021-04245-0 · Cited by 574 · see citing works
The N501Y spike substitution enhances SARS-CoV-2 transmission
Liu, Y., Liu, J., Plante, K. S., Plante, J. A., Xie, X., Zhang, X., Ku, Z., An, Z., Scharton, D., Schindewolf, C., et al. (2021) · doi:10.1101/2021.03.08.434499 · Cited by 574 · see citing works
Flagged first, then by citations
Research works printed but not linked: 8
- Jhun H, Park H-Y, Hisham Y, Song C-S, Kim S. SARS-CoV-2 Delta (B.1.617.2) variant: a unique T478K mutation in receptor binding motif (RBM) of spike gene. Immune Netw. 2021;21:e32.
- Hu J, Gao Q, He C, Huang A, Tang N, Wang K. Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neu- tralizing antibodies against SARS-CoV-2. Genes Dis. 2020;7:551-7.
- Cong Z, Evans JP, Qu P, Faraone J, Zheng YM, Carlin C, et al. Neutralization and Stability of SARS-CoV-2 Omicron Variant. bioRxiv, 2021; Preprint at https://doi.org/ 10.1101/2021.2012.2016.472934. · DOI
- Peng P, Hu J, Deng HJ, Liu BZ, Fang L, Wang K, et al. Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months. Cell Mol Immunol. 2021;18:490-1.
- Chan CW, Hui PY, Tam WC, Poon LLM, Nicholls J. Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus but with less severe infection in lung. In press (December 15th, 2021). https://www.med.hku.hk/en/news/press/ 20211215-omicron-sars-cov-2-infection.
- Syed F, Li W, Relich RF, Russell PM, Zhang S, Zimmerman MK, et al. Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles. medRxiv, 2021; Preprint at https://doi.org/ 10.1101/2021.12.20.21268048. · DOI
- Planas D, Saunders N, Maes P, Guivel-Benhassine F, Planchais C, Buchrieser J, et al. Considerable escape of SARS-CoV-2 variant Omicron to antibody neutralization. Nature. 2021;596:276-80.
- Tang J, Grubbs G, Lee Y, Huang C, Ravichandran S, Forgacs D, et al. Antibody affinity maturation and cross-variant activity following SARS-CoV-2 mRNA vacci- nation: Impact of prior exposure and sex. EBioMedicine. 2021;74:103748.
Cited by
Sorted by citations
Tamandjou Tchuem, C. R., Auvigne, V., Vaux, S., Montagnat, C., Paireau, J., Monnier Besnard, S., Gabet, A., Benhajkassen, N., Le Strat, Y., Parent Du Chatelet, I., et al. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.02.062 · Cited by 27 · see citing works
“1 which possesses a greater capacity of immune escape [29-31]; which when coupled to a decay of neutralizing antibodies further reduces VE against this variant.”
Sitaras, I., Jacobsen, H., Higdon, M. M., Dowling, W. E., Bar-Zeev, N., & Deloria Knoll, M. (2022) · npj Vaccines · doi:10.1038/s41541-022-00565-y · Cited by 17 · see citing works
- Authors
- Hu, J., Peng, P., Cao, X., Wu, K., Chen, J., Wang, K., Tang, N., & Huang, A.-L.
- Affiliations
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Corresponding author
- Huang, Ai-long
- Venue
- Cellular & Molecular Immunology
- Published
- 2022-01-11
- Volume
- 19
- Issue
- 2
- Pages
- 293-295
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC8749347
- OpenAlex
- W4206175278
- Cited by
- 204
- References
- 6
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 29 · 2023: 65 · 2022: 95 · 2021: 1
- FWCI
- 24.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cellular and Molecular Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (111 Project, [2021]02, 2021-05, U20A20392, 2017ZX10202203, 82102361, D20028)
- China Postdoctoral Science Foundation (202102, 2021M693924, 202105, 2017ZX10202203)
- Chongqing Science and Technology Commission (cstc2020jscx-fyzx0053, CSTCCXLJRC201719)
- Chongqing Medical University (D20028, 202105, CQMUNCP0302)
- Natural Science Foundation of Chongqing (cstc2020jscx-fyzx0053, cstc2021jcyj)
- Chongqing Postdoctoral Science Special Foundation (2010010005216630)
- Higher Education Discipline Innovation Project (D20028)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- Omicron variant, SARS-CoV-2, immune evasion, variants of concern, COVID-19 pandemic, viral evolution, SARS-CoV-2 spike protein
- MeSH terms
- A549 Cells, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Antibodies, Viral, Humans, Mutation, Transfection, Immune Evasion, Antibodies, Neutralizing, HEK293 Cells, Spike Glycoprotein, Coronavirus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
