Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant
Open accessAbstract
Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera collected after both primary and booster vaccination. We found a high proportion of post-primary vaccination sera were not responding against Omicron but boosting increased both neutralizing activity and percent of responding sera. We recommend reporting percent of responders alongside neutralization data to portray vaccine neutralization ability more accurately.
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- Authors
- Sitaras, I., Jacobsen, H., Higdon, M. M., Dowling, W. E., Bar-Zeev, N., & Deloria Knoll, M.
- Affiliations
- Johns Hopkins University (US)
- Helmholtz Centre for Infection Research (DE)
- Coalition for Epidemic Preparedness Innovations (US)
- Corresponding author
- Sitaras, Ioannis
- Venue
- npj Vaccines
- Published
- 2022-11-15
- Volume
- 7
- Issue
- 1
- Pages
- 147-147
- ISSN
- 2059-0105 (ISSN-L)
- PMC
- PMC9665011
- OpenAlex
- W4309188721
- Cited by
- 17
- References
- 50
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 7 · 2022: 2
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Vaccines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coalition for Epidemic Preparedness Innovations
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- COVID-19 pandemic, Omicron variant, virus neutralization, booster vaccination, basic immunization, neutralizing antibodies, vaccine response, vaccination policy
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