Cited by 17SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 epidemiological studies

Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant

Open access
Sitaras, Ioannis, Jacobsen, Henning, Higdon, Melissa M., Dowling, William E., Bar-Zeev, Naor, Deloria Knoll, Maria·2022·npj Vaccines

Abstract

Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera collected after both primary and booster vaccination. We found a high proportion of post-primary vaccination sera were not responding against Omicron but boosting increased both neutralizing activity and percent of responding sera. We recommend reporting percent of responders alongside neutralization data to portray vaccine neutralization ability more accurately.

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Research works printed but not linked: 3

  1. [6]Cele S Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization Nature 2022 602 654 656 10.1038/s41586-021-04387-1 35016196 PMC8866126 · DOI · Paper page
  2. [27]Lusvarghi, S. et al. SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster. Preprint at https://www.biorxiv.org/content/10.1101/2021.12.22.473880v1 (2021). · DOI
  3. [33]Pérez-Then, E. et al. Immunogenicity of heterologous BNT162b2 booster in fully vaccinated individuals with CoronaVac against SARS-CoV-2 variants Delta and Omicron: The Dominican Republic Experience. Preprint at https://www.medrxiv.org/content/10.1101/2021.12.27.21268459v1 (2021). · DOI

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Authors
Sitaras, I., Jacobsen, H., Higdon, M. M., Dowling, W. E., Bar-Zeev, N., & Deloria Knoll, M.
Affiliations
  • Johns Hopkins University (US)
  • Helmholtz Centre for Infection Research (DE)
  • Coalition for Epidemic Preparedness Innovations (US)
Corresponding author
Sitaras, Ioannis
Venue
npj Vaccines
Published
2022-11-15
Volume
7
Issue
1
Pages
147-147
ISSN
2059-0105 (ISSN-L)
OpenAlex
W4309188721
Cited by
17
References
50
Citations by year
2025: 1 · 2024: 7 · 2023: 7 · 2022: 2
FWCI
0.65
Type
journal article
Language
en
Open access
Locations
  • npj Vaccines (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Coalition for Epidemic Preparedness Innovations
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
Keywords
COVID-19 pandemic, Omicron variant, virus neutralization, booster vaccination, basic immunization, neutralizing antibodies, vaccine response, vaccination policy

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