The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair
Open accessAbstract
We report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The hydrogel was prepared by coordinative cross-linking of multi-arm thiolated polyethylene glycol (SH-PEG) with silver nitrate (AgNO3). Due to the dynamic nature of Ag-S coordination bond and bacteria-killing activity of Ag+, the resultant coordinative hydrogel featured self-healing, injectable and antibacterial properties. In this study, we synchronously loaded an angiogenic drug, desferrioxamine (DFO), in the coordinative hydrogel during cross-linking. We finally obtained a multifunctional hydrogel that is manageable, resistant to mechanical irritation, antibacterial and angiogenic in vitro. Our in vivo studies further demonstrated that the injectable self-healing hydrogel could efficiently repair diabetic skin wounds with low bacteria-infection and enhance angiogenic activity. In short, besides diabetic skin wound repair, such dynamic multifunctional hydrogel scaffolds would show great promise in the regeneration of different types of exposed wounds, in particular, in situations with disturbed physiological functions, high risk of bacterial infections, and external mechanical irritation.
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Cites
Stabilization of HIF-1α is critical to improve wound healing in diabetic mice
Botusan, I. R., Sunkari, V. G., Savu, O., Catrina, A. I., Grünler, J., Lindberg, S., Pereira, T., Ylä-Herttuala, S., Poellinger, L., Brismar, K., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805230105 · Cited by 533
Soong, G., Martin, F. J., Chun, J., Cohen, T. S., Ahn, D. S., & Prince, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.295386 · Cited by 73
Cited by
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Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
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Aswathy, S. H., Narendrakumar, U., & Manjubala, I. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03719 · Cited by 482
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Xie, C., Wang, X., He, H., Ding, Y., & Lu, X. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909954 · Cited by 482
Nanocomposite hydrogel-based strain and pressure sensors: a review
Sun, X., Yao, F., & Li, J. (2020) · Journal of Materials Chemistry A · doi:10.1039/d0ta06965e · Cited by 420
Design Challenges in Polymeric Scaffolds for Tissue Engineering
Echeverria Molina, M. I., Malollari, K. G., & Komvopoulos, K. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.617141 · Cited by 397
Metadata
- Authors
- Chen, H., Cheng, R., Zhao, X., Zhang, Y., Tam, A., Yan, Y., Shen, H., Zhang, Y. S., Qi, J., Feng, Y., Liu, L., Pan, G., Cui, W., & Deng, L.
- Venue
- NPG Asia Materials
- Published
- 2019-01-23
- Volume
- 11
- Issue
- 1
- ISSN
- 1884-4049 (ISSN-L)
- 1884-4057
- OpenAlex
- W2911903264
- Cited by
- 366
- References
- 2
- FWCI
- 30.14
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chen, H., Cheng, R., Zhao, X., Zhang, Y., Tam, A., Yan, Y., Shen, H., Zhang, Y. S., Qi, J., Feng, Y., Liu, L., Pan, G., Cui, W., & Deng, L. (2019). An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair. NPG Asia Materials. https://doi.org/10.1038/s41427-018-0103-9
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