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Cited by 74Wound Healing and TreatmentsHydrogels: synthesis, properties, applicationsSurgical Sutures and Adhesives

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Mussel-inspired hydrogel with injectable self-healing and antibacterial properties promotes wound healing in burn wound infection

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Sun, Ao, Hu, Danrong, He, Xinye, Ji, Xiao, Li, Tao, Wei, Xiawei, Qian, Zhiyong·2022·NPG Asia Materials
DOI 10.1038/s41427-022-00434-z
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Abstract

Burn wound infections cause serious problems for public health. More than 180,000 patients die from burns every year worldwide. In addition, the difficulty of healing wounds and wound infections caused by burns affects the mental health of patients. Therefore, it is very important to develop a wound dressing that can promote wound repair and exhibits good antibacterial effects. Here, we used oxidized konjac glucomannan (OKGM), γ-poly(glutamic acid) modified with dopamine and L -cysteine (γ-PGA-DA-Cys) and ε-polylysine (ε-PL) to produce an OKGM/γ-PGA-DA-Cys/ε-PL (OKPP) hydrogel. This hydrogel was produced by thiol-aldehyde addition and Schiff-base reactions and has the ability to be injected and self-heal. The results showed that the hydrogel exhibits good antibacterial effects on Pseudomonas aeruginosa and Staphylococcus aureus and has antioxidant effects in vitro. Moreover, the hydrogel also exhibits good adhesion. In a burn wound infection model, the hydrogel promoted wound healing and reduced the production of inflammation. These results proved that the hydrogel has clinical potential as a wound dressing for burn wound infection.

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  • The incorporation of DOPA or other catechol compounds endows hydrogels with enhanced adhesion and antimicrobial activity.

    “The incorporation of DOPA or other catechol compounds endows hydrogels with enhanced adhesion and antimicrobial activity [36,105,106,107].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [106]

    The Introduction and Adhesive strength tests section say dopamine’s catechol group enhances hydrogel adhesion. The In vitro antibacterial properties section attributes the hydrogel’s antibacterial activity to added ε-polylysine, not to dopamine or other catechol compounds. The source therefore does not support the claimed catechol-derived antimicrobial activity. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 51

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Metadata

Authors
Sun, A., Hu, D., He, X., Ji, X., Li, T., Wei, X., & Qian, Z.
Affiliations
Sichuan University (CN)
Corresponding author
  • Wei, Xiawei
  • Qian, Zhiyong
ORCID
Venue
NPG Asia Materials
Publisher
Springer Science and Business Media LLC
Published
2022-11-04
Volume
14
Issue
1
ISSN
  • 1884-4049 (ISSN-L)
  • 1884-4057
DOI
10.1038/s41427-022-00434-z
OpenAlex
W4308072644
Cited by
74
References
0
Citations by year
2026: 15 · 2025: 23 · 2024: 26 · 2023: 10
FWCI
6.37
Type
journal article
Language
en
Open access
Licence
Locations
NPG Asia Materials (publishedVersion, cc-by)
Funders
  • National Natural Science Foundation of China (2017YFC1103502, 31771096, NSFC31525009, 31930067, ZYGD18002)
  • Sichuan University (2017YFC1103502, ZYGD18002, 31771096)
  • National Key Research and Development Program of China (ZYGD18002, 2017YFC1103502, 31771096)
  • West China Hospital, Sichuan University (ZYGD18002, 31771096, 2017YFC1103502)
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
mussel-inspired hydrogel, injectable hydrogel, self-healing hydrogels, antibacterial hydrogel, wound dressings, burn wound infection, poly-γ-glutamic acid, dopamine modification, cysteine, ε-polylysine, Schiff base, Pseudomonas aeruginosa, Staphylococcus aureus, antioxidant activity, hydrogel adhesion, inflammation reduction, wound healing

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