The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche
Open accessAbstract
Metastatic cancers produce exosomes that condition pre-metastatic niches in remote microenvironments to favor metastasis. In contrast, here we show that exosomes from poorly metastatic melanoma cells can potently inhibit metastasis to the lung. These “non-metastatic” exosomes stimulate an innate immune response through the expansion of Ly6C low patrolling monocytes (PMo) in the bone marrow, which then cause cancer cell clearance at the pre-metastatic niche, via the recruitment of NK cells and TRAIL-dependent killing of melanoma cells by macrophages. These events require the induction of the Nr4a1 transcription factor and are dependent on pigment epithelium-derived factor (PEDF) on the outer surface of exosomes. Importantly, exosomes isolated from patients with non-metastatic primary melanomas have a similar ability to suppress lung metastasis. This study thus demonstrates that pre-metastatic tumors produce exosomes, which elicit a broad range of PMo-reliant innate immune responses via trigger(s) of immune surveillance, causing cancer cell clearance at the pre-metastatic niche.
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Cited by
The biology , function , and biomedical applications of exosomes
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“PEDF (pigment epithelium-derived factor) on the surface of exosomes from mouse and human nonmetastatic melanoma cells elicits the expansion of patrollingmonocytes by NR4A1 (nuclear receptor subfamily 4 group A member 1) induction, which suppresses metastasis in the lungs of mice (156).”
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Exosomes in cancer development, metastasis, and immunity
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The crosstalk: exosomes and lipid metabolism
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Metadata
- Authors
- Plebanek, M. P., Angeloni, N. L., Vinokour, E., Li, J., Henkin, A., Martinez-Marin, D., Filleur, S., Bhowmick, R., Henkin, J., Miller, S. D., Ifergan, I., Lee, Y., Osman, I., Thaxton, C. S., & Volpert, O. V.
- Venue
- Nature Communications
- Published
- 2017-11-06
- Volume
- 8
- Issue
- 1
- Pages
- 1319-1319
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2765148841
- Cited by
- 285
- References
- 12
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- gold
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- Plebanek, M. P., Angeloni, N. L., Vinokour, E., Li, J., Henkin, A., Martinez-Marin, D., Filleur, S., Bhowmick, R., Henkin, J., Miller, S. D., Ifergan, I., Lee, Y., Osman, I., Thaxton, C. S., & Volpert, O. V. (2017). Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche. Nature Communications. https://doi.org/10.1038/s41467-017-01433-3
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