The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation
Open accessAbstract
Plastics, including poly(ethylene terephthalate) (PET), possess many desirable characteristics and thus are widely used in daily life. However, non-biodegradability, once thought to be an advantage offered by plastics, is causing major environmental problem. Recently, a PET-degrading bacterium,Ideonella sakaiensis, was identified and suggested for possible use in degradation and/or recycling of PET. However, the molecular mechanism of PET degradation is not known. Here we report the crystal structure of I. sakaiensis PETase (Is PETase) at 1.5 Å resolution.Is PETase has a Ser–His-Asp catalytic triad at its active site and contains an optimal substrate binding site to accommodate four monohydroxyethyl terephthalate (MHET) moieties of PET. Based on structural and site-directed mutagenesis experiments, the detailed process of PET degradation into MHET, terephthalic acid, and ethylene glycol is suggested. Moreover, other PETase candidates potentially having high PET-degrading activities are suggested based on phylogenetic tree analysis of 69 PETase-like proteins.
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Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to a substrate
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Metadata
- Authors
- Joo, S., Cho, I. J., Seo, H., Son, H. F., Sagong, H.-Y., Shin, T. J., Choi, S. Y., Lee, S. Y., & Kim, K.-J.
- Venue
- Nature Communications
- Published
- 2018-01-26
- Volume
- 9
- Issue
- 1
- Pages
- 382-382
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2786189709
- Cited by
- 802
- References
- 7
- FWCI
- 19.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Joo, S., Cho, I. J., Seo, H., Son, H. F., Sagong, H.-Y., Shin, T. J., Choi, S. Y., Lee, S. Y., & Kim, K.-J. (2018). Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation. Nature Communications. https://doi.org/10.1038/s41467-018-02881-1
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