The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
The fluorination effect of fluoroamphiphiles in cytosolic protein delivery
Open accessAbstract
Direct delivery of proteins into cells avoids many drawbacks of gene delivery, and thus has emerging applications in biotherapy. However, it remains a challenging task owing to limited charges and relatively large size of proteins. Here, we report an efficient protein delivery system via the co-assembly of fluoroamphiphiles and proteins into nanoparticles. Fluorous substituents on the amphiphiles play essential roles in the formation of uniform nanoparticles, avoiding protein denaturation, efficient endocytosis, and maintaining low cytotoxicity. Structure-activity relationship studies reveal that longer fluorous chain length and higher fluorination degree contribute to more efficient protein delivery, but excess fluorophilicity on the polymer leads to the pre-assembly of fluoroamphiphiles into stable vesicles, and thus failed protein encapsulation and cytosolic delivery. This study highlights the advantage of fluoroamphiphiles over other existing strategies for intracellular protein delivery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse
Schwarze, S. R., Ho, A., Vocero-Akbani, A., & Dowdy, S. F. (1999) · Science · doi:10.1126/science.285.5433.1569 · Cited by 2,416
Protein Therapeutics: A Summary and Pharmacological Classification
Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
Mitragotri, S., Burke, P. A., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4363 · Cited by 1,702
Fluorine substituent effects (on bioactivity)
Smart, B. E. (2001) · Journal of Fluorine Chemistry · doi:10.1016/s0022-1139(01)00375-x · Cited by 1,497
Zuris, J. A., Thompson, D. B., Shu, Y., Guilinger, J. P., Bessen, J. L., Hu, J. H., Maeder, M. L., Joung, J. K., Chen, Z.-Y., & Liu, D. R. (2015) · Nature Biotechnology · doi:10.1038/nbt.3081 · Cited by 1,460
Self-citationFluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research
Krafft, M. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00107-7 · Cited by 550
Gudipati, C. S., Finlay, J. A., Callow, J. A., Callow, M. E., & Wooley, K. L. (2005) · Langmuir · doi:10.1021/la048015o · Cited by 479
Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic Applications
Bachelder, E. M., Beaudette, T. T., Broaders, K. E., Dashe, J., & Fréchet, J. M. J. (2008) · Journal of the American Chemical Society · doi:10.1021/ja803947s · Cited by 475
Hydrophobic modifications of cationic polymers for gene delivery
Liu, Z., Zhang, Z., Zhou, C., & Jiao, Y. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.007 · Cited by 432
Self-citationWang, M., Liu, H., Li, L., & Cheng, Y. (2014) · Nature Communications · doi:10.1038/ncomms4053 · Cited by 415
Self-citation
Cited by
Xu, J., Lv, J., Zhuang, Q., Yang, Z., Cao, Z., Xu, L., Pei, P., Wang, C., Wu, H., Dong, Z., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-00781-4 · Cited by 561
Self-citationZhang, C., Yan, K., Fu, C., Peng, H., Hawker, C. J., & Whittaker, A. K. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00632 · Cited by 493
Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics
Wang, Z., Zou, Y., Li, Y., & Cheng, Y. (2020) · Small · doi:10.1002/smll.201907042 · Cited by 459
Self-citationStrategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
Zhang, S., Shen, J., Li, D., & Cheng, Y. (2021) · Theranostics · doi:10.7150/thno.47007 · Cited by 430
Self-citationLiu, C., Wan, T., Wang, H., Zhang, S., Ping, Y., & Cheng, Y. (2019) · Science Advances · doi:10.1126/sciadv.aaw8922 · Cited by 396
Self-citation
Metadata
- Authors
- Zhang, Z., Shen, W., Ling, J., Yan, Y., Hu, J., & Cheng, Y.
- Venue
- Nature Communications
- Published
- 2018-04-10
- Volume
- 9
- Issue
- 1
- Pages
- 1377-1377
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2797771065
- Cited by
- 339
- References
- 51
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The fluorination effect of fluoroamphiphiles in cytosolic protein delivery. https://app.cochat.ai/papers/10.1038/s41467-018-03779-8
- The paper
- Zhang, Z., Shen, W., Ling, J., Yan, Y., Hu, J., & Cheng, Y. (2018). The fluorination effect of fluoroamphiphiles in cytosolic protein delivery. Nature Communications. https://doi.org/10.1038/s41467-018-03779-8
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
