The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors
Open accessAbstract
Vaccines to induce effective and sustained antitumor immunity have great potential for postoperative cancer therapy. However, a robust cancer vaccine simultaneously eliciting tumor-specific immunity and abolishing immune resistance continues to be a challenge. Here we present a personalized cancer vaccine (PVAX) for postsurgical immunotherapy. PVAX is developed by encapsulating JQ1 (a BRD4 inhibitor) and indocyanine green (ICG) co-loaded tumor cells with a hydrogel matrix. Activation of PVAX by 808 nm NIR laser irradiation significantly inhibits the tumor relapse by promoting the maturation of dendritic cells and eliciting tumor infiltration of cytotoxic T lymphocytes. A mechanical study reveals that NIR light-triggered antigen release and JQ1-mediated PD-L1 checkpoint blockade cumulatively contribute to the satisfied therapeutic effect. Furthermore, PVAX prepared from the autologous tumor cells induces patient-specific memory immune response to prevent tumor recurrence and metastasis. The PVAX model might provide novel insights for postoperative immunotherapy.
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Song, R., Li, T., Ye, J., Sun, F., Hou, B., Saeed, M., Gao, J., Wang, Y., Zhu, Q., Xu, Z., et al. (2021) · Advanced Materials · doi:10.1002/adma.202101155 · Cited by 308
Self-citationThe BET family in immunity and disease
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Delfi, M., Sartorius, R., Ashrafizadeh, M., Sharifi, E., Zhang, Y., De Berardinis, P., Zarrabi, A., Varma, R. S., Tay, F. R., Smith, B. R., et al. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101119 · Cited by 253
Metadata
- Authors
- Wang, T., Wang, D., Yu, H., Feng, B., Zhou, F., Zhang, H., Zhou, L., Jiao, S., & Li, Y.
- Venue
- Nature Communications
- Published
- 2018-04-18
- Volume
- 9
- Issue
- 1
- Pages
- 1532-1532
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2800103955
- Cited by
- 391
- References
- 45
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, T., Wang, D., Yu, H., Feng, B., Zhou, F., Zhang, H., Zhou, L., Jiao, S., & Li, Y. (2018). A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors. Nature Communications. https://doi.org/10.1038/s41467-018-03915-4
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