The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
Open accessAbstract
Cancer cells in hypoxic tumors are remarkably resistant to photodynamic therapy. Here, we hypothesize that an oxygen and Pt(II) self-generating multifunctional nanocomposite could reverse the hypoxia-triggered PDT resistance. The nanocomposite contains Pt(IV) and chlorin e6, in which upconversion nanoparticles are loaded to convert 980 nm near-infrared light into 365 nm and 660 nm emissions. Upon accumulation at the tumor site, a 980 nm laser is used to trigger the nanocomposite to generate O 2 for consumption in the PDT process and to produce cytotoxic reactive oxygen species. The composite also releases active Pt(II) for synergistic photo-chemo therapy to enhance antitumor efficiency. The oxygen and Pt(II) self-generating prodrug is shown to have high potential to inhibit tumors out of the range of UV light, to overcome the hypoxia-triggered PDT resistance and significantly improve anticancer efficacy by the synergistic PDT-chemotherapy.
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Cited by
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Metadata
- Authors
- Xu, S., Zhu, X., Zhang, C., Huang, W., Zhou, Y., & Yan, D.
- Venue
- Nature Communications
- Published
- 2018-05-24
- Volume
- 9
- Issue
- 1
- Pages
- 2053-2053
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2804716737
- Cited by
- 292
- References
- 24
- FWCI
- 14.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xu, S., Zhu, X., Zhang, C., Huang, W., Zhou, Y., & Yan, D. (2018). Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor. Nature Communications. https://doi.org/10.1038/s41467-018-04318-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
