Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy
Open accessAbstract
Abstract Various types of nanoparticles have been proposed for targeted drug delivering, imaging, and tracking of therapeutic agents. However, highly biocompatible nanoparticles with structure-induced fluorescence and capability to conjugate with biomarkers and drugs remain lacking. This research proposes and synthesizes fluorescent nanoparticles (f-PNPs) assembled by cyclic peptides to combine imaging and drug delivering for esophageal cancer (EC). To achieve tumor targeting, f-PNPs are first conjugated with RGD moieties to selectively target EC cells via αvβ3 integrin; the nanoparticles are then embedded with epirubicin (EPI). Cell viability assays and analysis of tissue histology reveal that EPI-loaded RGD-f-PNPs (RGD-f-PNPs/EPI) led to significantly reduced cardiotoxicity and improved anti-tumor activity compared to EPI alone. Moreover, the drug delivery to tumor sites and therapeutic responses could be monitored with near-infrared fluorescence using RGD-f-PNPs/EPI. This unique nanoparticle system may lead to potential approaches for bioorganic fluorescence-based delivering, imaging, and drug release tracking.
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NIR fluorescent nanoparticles conjugated with cyclo[-[D-Ala-L-Glu-D-Ala-L-Trp)2] altered with RGD and loaded with epirubicin demonstrated enhanced accumulation in tumors through αvβ3 binding and EPR, causing improved therapeutic efficiency.
“NIR fluorescent NPs congregated with cyclo[-[D-Ala-L-Glu-D-Ala-L-Trp)2] were altered with RGD (Arg-Gly-Asp) moieties and then loaded with the chemo drug, epirubicin. The nanoassembly demonstrated enhanced accumulation in tumors through αvβ3 binding and the EPR effect, causing improved therapeutic efficiency [47].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [47]
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Cites
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339 · see citing works
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., & Weiss, S. (2005) · Science · doi:10.1126/science.1104274 · Cited by 7,794 · see citing works
The nature of .pi.-.pi. interactions
Hunter, C. A., & Sanders, J. K. M. (1990) · Journal of the American Chemical Society · doi:10.1021/ja00170a016 · Cited by 5,365 · see citing works
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552 · see citing works
Probing the Cytotoxicity of Semiconductor Quantum Dots
Derfus, A. M., Chan, W. C. W., & Bhatia, S. N. (2003) · Nano Letters · doi:10.1021/nl0347334 · Cited by 3,394 · see citing works
Therapeutic Nanoparticles for Drug Delivery in Cancer
Cho, K., Wang, X., Nie, S., Chen, Z. (., & Shin, D. M. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1441 · Cited by 2,978 · see citing works
Enzinger, P. C., & Mayer, R. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035010 · Cited by 2,511 · see citing works
Self-assembling organic nanotubes based on a cyclic peptide architecture
Ghadiri, M. R., Granja, J. R., Milligan, R. A., McRee, D. E., & Bernstein, N. K. (1993) · Nature · doi:10.1038/366324a0 · Cited by 1,747 · see citing works
Rethinking the term “pi-stacking”
Martinez, C. R., & Iverson, B. L. (2012) · Chemical Science · doi:10.1039/c2sc20045g · Cited by 1,667 · see citing works
Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications
Shi, J., Votruba, A. R., Farokhzad, O. C., & Langer, R. (2010) · Nano Letters · doi:10.1021/nl102184c · Cited by 1,651 · see citing works
Acidic extracellular microenvironment and cancer
Kato, Y., Ozawa, S., Miyamoto, C., Maehata, Y., Suzuki, A., Maeda, T., & Baba, Y. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-89 · Cited by 1,295 · see citing works
Function and Mechanism of Zinc Metalloenzymes
McCall, K. A., Huang, C.-C., & Fierke, C. A. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1437s · Cited by 1,144 · see citing works
Designing multifunctional quantum dots for bioimaging, detection, and drug delivery
Zrazhevskiy, P., Sena, M., & Gao, X. (2010) · Chemical Society Reviews · doi:10.1039/b915139g · Cited by 999 · see citing works
RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis
Danhier, F., Breton, A. L., & Véronique Préat, A. (2012) · Molecular Pharmaceutics · doi:10.1021/mp3002733 · Cited by 987 · see citing works
Webb, A., Cunningham, D., Scarffe, J. H., Harper, P., Norman, A. R., Joffe, J., Hughes, M., Mansi, J., Findlay, M., Hill, A., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.1.261 · Cited by 868 · see citing works
Targeting of drugs and nanoparticles to tumors
Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200910104 · Cited by 833 · see citing works
Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities
Napier, K. J. (2014) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v6.i5.112 · Cited by 797 · see citing works
The cytotoxicity of cadmium-based quantum dots
Chen, N., He, Y., Su, Y., Li, X., Huang, Q., Wang, H., Zhang, X., Tai, R., & Fan, C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.070 · Cited by 722 · see citing works
Yu, M. K., Jeong, Y. Y., Park, J., Park, S.-J., Kim, J. W., Min, J. J., Kim, K., & Jon, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800857 · Cited by 621 · see citing works
Carbon nanotubes for delivery of small molecule drugs
Wong, B. S., Yoong, S. L., Jagusiak, A., Pańczyk, T., Ho, H. K., Ang, W. H., & Pastorin, G. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.005 · Cited by 584 · see citing works
Fluorescent metal–organic framework for selective sensing of nitroaromatic explosives
Gole, B., Bar, A. K., & Mukherjee, P. S. (2011) · Chemical Communications · doi:10.1039/c1cc15594f · Cited by 504 · see citing works
Hoebe, R. A., van Oven, C. H., Gadella, T. W. J., Dhonukshe, P., Noorden, C. J. F. V., & Manders, E. M. M. (2007) · Nature Biotechnology · doi:10.1038/nbt1278 · Cited by 438 · see citing works
Xie, J., Chen, K., Lee, H., Xu, C., Hsu, A. R., Peng, S., Chen, X. S., & Sun, S. (2008) · Journal of the American Chemical Society · doi:10.1021/ja802003h · Cited by 419 · see citing works
Multivalent Effects of RGD Peptides Obtained by Nanoparticle Display
Montet, X., Funovics, M. A., Montet-Abou, K., Weissleder, R., & Josephson, L. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060515m · Cited by 388 · see citing works
Quantum dots as photosensitizers?
Bakalova, R., Ohba, H., Zhelev, Z., et al. (2004) · Nature Biotechnology · doi:10.1038/nbt1104-1360 · Cited by 382 · see citing works
Sam, S., Touahir, L., Andresa, J. S., et al. (2009) · Langmuir · doi:10.1021/la902220a · Cited by 377 · see citing works
Fan, Z., Sun, L., Huang, Y., Wang, Y., & Zhang, M. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2015.312 · Cited by 369 · see citing works
Self-citationA Method for the High Efficiency of Water-Soluble Carbodiimide-Mediated Amidation
Sehgal, D., & Vijay, I. K. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1144 · Cited by 346 · see citing works
Pieper, J., Hafmans, T. G. M., Veerkamp, J. H., & Kuppevelt, T. H. V. (2000) · Biomaterials · doi:10.1016/s0142-9612(99)00222-7 · Cited by 323 · see citing works
Dixit, R., & Cyr, R. J. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01868.x · Cited by 319 · see citing works
Zelzer, M., & Ulijn, R. V. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00035c · Cited by 302 · see citing works
Epirubicin cardiotoxicity: an analysis of 469 patients with metastatic breast cancer.
Ryberg, M., Nielsen, D. L., Skovsgaard, T., Hansen, J., Jensen, B. V., & Dombernowsky, P. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.11.3502 · Cited by 288 · see citing works
Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells
Watson, P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.05.003 · Cited by 265 · see citing works
Epidemiology of Esophageal Cancer
Wheeler, J. B., & Reed, C. E. (2012) · Surgical Clinics of North America · doi:10.1016/j.suc.2012.07.008 · Cited by 256 · see citing works
di Pietro, M., Canto, M. I., & Fitzgerald, R. C. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.041 · Cited by 240 · see citing works
Protein amyloids develop an intrinsic fluorescence signature during aggregation
Chan, F. T. S., Schierle, G. S. K., Kumita, J. R., Bertoncini, C. W., Dobson, C. M., & Kaminski, C. F. (2013) · The Analyst · doi:10.1039/c3an36798c · Cited by 230 · see citing works
Meinardi, M. T., van Veldhuisen, D. J., Gietema, J. A., Dolsma, W. V., Boomsma, F., van den Berg, M. P., Volkers, C., Haaksma, J., de Vries, E. G. E., Sleijfer, D. T., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.10.2746 · Cited by 206 · see citing works
A Label‐Free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence
Pinotsi, D., Buell, A. K., Dobson, C. M., Schierle, G. S. K., & Kaminski, C. F. (2013) · ChemBioChem · doi:10.1002/cbic.201300103 · Cited by 175 · see citing works
Design of new quantum dot materials for deep tissue infrared imaging
Cassette, E., Helle, M., Bezdetnaya, L., et al. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.016 · Cited by 154 · see citing works
Hua Zhu, C., Zhang, H., Jin, F., Fang, M., Huang, M., Yang, C. S., Chen, T., Fu, L., & Pan, Z. (2014) · Oncotarget · doi:10.18632/oncotarget.1903 · Cited by 147 · see citing works
Self-citationpH-sensitive polymers for drug delivery
Huh, K. M., Kang, H. C., Lee, Y. J., & Bae, Y. H. (2012) · Macromolecular Research · doi:10.1007/s13233-012-0059-5 · Cited by 139 · see citing works
Esophageal cancer: a review and update.
Layke, J. C., & Lopez, P. P. (2006) · PubMed · Cited by 123 · see citing works
Structural Chemistry of a Green Fluorescent Protein Zn Biosensor
Barondeau, D. P., Kassmann, C. J., Tainer, J. A., & Getzoff, E. D. (2002) · Journal of the American Chemical Society · doi:10.1021/ja0176954 · Cited by 117 · see citing works
Hamzah, J., Kotamraju, V. R., Seo, J. W., Agemy, L., Fogal, V., Mahakian, L. M., Peters, D., Roth, L., Gagnon, M.-H., Ferrara, K. W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104540108 · Cited by 115 · see citing works
Saalbach, A., Wetzel, A., Haustein, U., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208559 · Cited by 97 · see citing works
Cummings, R. T., Salowe, S. P., Cunningham, B. R., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062171599 · Cited by 96 · see citing works
Handelman, A., Kuritz, N., Natan, A., & Rosenman, G. I. (2015) · Langmuir · doi:10.1021/acs.langmuir.5b02784 · Cited by 92 · see citing works
pH-Sensitive Polymers for Drug Delivery
(2005) · CRC Press eBooks · doi:10.1201/9780849348129-6 · Cited by 86 · see citing works
Song, C., Zhong, Y., Jiang, X., et al. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00853 · Cited by 77 · see citing works
Campone, M., Roche, H. H., Kerbrat, P., et al. (2005) · Annals of Oncology · doi:10.1093/annonc/mdi251 · Cited by 43 · see citing works
Chan, H., Chu, T., Chien, H.-F., Sun, C., Wang, E., Pan, H., Kuo, H., Hu, T., Lai, K.-H., Cheng, J., et al. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-83 · Cited by 30 · see citing works
alpha6 integrin expression in esophageal carcinoma.
Tanaka, Y., Mimori, K., Shiraishi, T., et al. (2000) · International Journal of Oncology · doi:10.3892/ijo.16.4.725 · Cited by 19 · see citing works
Miller, S. E., & Veale, R. B. (2001) · Cell Biology International · doi:10.1006/cbir.2000.0678 · Cited by 15 · see citing works
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Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis
Subhan, M. A., Parveen, F., Filipczak, N., Yalamarty, S. S. K., & Torchilin, V. P. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13030389 · Cited by 98 · see citing works
“The nanoassembly demonstrated enhanced accumulation in tumors through αvβ3 binding and the EPR effect, causing improved therapeutic efficiency [47].”
BackgroundSelf-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications
Fu, D., Liu, D., Zhang, L., & Sun, L. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.07.011 · Cited by 79 · see citing works
Self-citationLiu, D., Fu, D., Zhang, L., & Sun, L. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.09.009 · Cited by 45 · see citing works
Self-citation
- Authors
- Fan, Z., Chang, Y., Cui, C., Sun, L., Wang, D. H., Pan, Z., & Zhang, M.
- Affiliations
- Tongji University (CN)
- The University of Texas at Arlington (US)
- Northwestern Polytechnical University (CN)
- VA North Texas Health Care System (US)
- The Ohio State University Wexner Medical Center (US)
- Corresponding author
- Pan, Zui
- Zhang, Mingjun
- Venue
- Nature Communications
- Published
- 2018-07-04
- Volume
- 9
- Issue
- 1
- Pages
- 2605-2605
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6031624
- OpenAlex
- W2809987360
- Cited by
- 151
- References
- 54
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 14 · 2023: 19 · 2022: 22 · 2021: 23 · 2020: 33 · 2019: 16 · 2018: 2
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ohio State University
- Pelotonia
- National Institutes of Health (1r01ca226251-01)
- National Cancer Institute (R01CA185055, R01 CA226251)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- cyclic peptides, esophageal cancer, RGD peptide, αvβ3 integrin targeting, epirubicin, near-infrared fluorescence imaging, targeted drug delivery, cardiotoxicity, tumor targeting, bioconjugation
- MeSH terms
- Animals, Antibiotics, Antineoplastic, Drug Compounding, Esophageal Neoplasms, Fluorescence, Humans, Injections, Intraperitoneal, Male, Mice, Nude, Oligopeptides, Peptides, Cyclic, Epirubicin, Drug Delivery Systems, Drug Monitoring, Spectroscopy, Near-Infrared, Xenograft Model Antitumor Assays, Integrin alphaVbeta3, Cell Line, Tumor, Mice, Nanoparticles, Molecular Imaging
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