The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery
Open accessAbstract
Covalent organic frameworks (COFs) as drug-delivery carriers have been mostly evaluated in vitro due to the lack of COFs nanocarriers that are suitable for in vivo studies. Here we develop a series of water-dispersible polymer-COF nanocomposites through the assembly of polyethylene-glycol-modified monofunctional curcumin derivatives (PEG-CCM) and amine-functionalized COFs (APTES-COF-1) for in vitro and in vivo drug delivery. The real-time fluorescence response shows efficient tracking of the COF-based materials upon cellular uptake and anticancer drug (doxorubicin (DOX)) release. Notably, in vitro and in vivo studies demonstrate that PEG-CCM@APTES-COF-1 is a smart carrier for drug delivery with superior stability, intrinsic biodegradability, high DOX loading capacity, strong and stable fluorescence, prolonged circulation time and improved drug accumulation in tumors. More intriguingly, PEG 350-CCM@APTES-COF-1 presents an effective targeting strategy for brain research. We envisage that PEG-CCM@APTES-COF-1 nanocomposites represent a great promise toward the development of a multifunctional platform for cancer-targeted in vivo drug delivery.
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Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Cited by
Liu, R., Tan, K. T., Gong, Y., Chen, Y., Li, Z., Xie, S., He, T., Lu, Z., Yang, H., & Jiang, D. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00620c · Cited by 1,083
Zhang, W., Taheri-Ledari, R., Ganjali, F., Afruzi, F. H., Hajizadeh, Z., Saeidirad, M., Qazi, F. S., Kashtiaray, A., Sehat, S. S., Hamblin, M. R., et al. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09577 · Cited by 79
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Metadata
- Authors
- Zhang, G., Li, X., Liao, Q., Liu, Y., Xi, K., Huang, W., & Jia, X.
- Venue
- Nature Communications
- Published
- 2018-07-17
- Volume
- 9
- Issue
- 1
- Pages
- 2785-2785
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2845838257
- Cited by
- 512
- References
- 1
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, G., Li, X., Liao, Q., Liu, Y., Xi, K., Huang, W., & Jia, X. (2018). Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery. Nature Communications. https://doi.org/10.1038/s41467-018-04910-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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