The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination
Open accessAbstract
Severe liver abscess infections caused by hypervirulent clonal-group CG23 Klebsiella pneumoniae have been increasingly reported since the mid-1980s. Strains typically possess several virulence factors including an integrative, conjugative element ICE Kp encoding the siderophore yersiniabactin and genotoxin colibactin. Here we investigate CG23’s evolutionary history, showing several deep-branching sublineages associated with distinct ICE Kp acquisitions. Over 80% of liver abscess isolates belong to sublineage CG23-I, which emerged in ~1928 following acquisition of ICE Kp10 (encoding yersiniabactin and colibactin), and then disseminated globally within the human population. CG23-I’s distinguishing feature is the colibactin synthesis locus, which reportedly promotes gut colonisation and metastatic infection in murine models. These data show circulation of CG23 K . pneumoniae decades before the liver abscess epidemic was first recognised, and provide a framework for future epidemiological and experimental studies of hypervirulent K . pneumoniae . To support such studies we present an open access, completely sequenced CG23-I human liver abscess isolate, SGH10.
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1 retracted
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Bayesian Phylogenetics with BEAUti and the BEAST 1.7
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Cited by
Hypervirulent Klebsiella pneumoniae
Russo, T. A., & Marr, C. M. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-19 · Cited by 1,311
Hypervirulent Klebsiella pneumoniae
Chen, J., Zhang, H., & Liao, X. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s418523 · Cited by 65
Yuan, L., Li, X., Du, L., Su, K., Zhang, J., Liu, P., He, Q., Zhang, Z., Peng, D., Shen, L., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00282 · Cited by 27
Neumann, B., Lippmann, N., Wendt, S., Karlas, T., Lübbert, C., Werner, G., Pfeifer, Y., & Schuster, C. F. (2022) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-022-00521-7 · Cited by 12
Metadata
- Authors
- Lam, M. M. C., Wyres, K. L., Duchêne, S., Wick, R. R., Judd, L. M., Gan, Y.-H., Hoh, C.-H., Archuleta, S., Molton, J. S., Kalimuddin, S., Koh, T. H., Passet, V., Brisse, S., & Holt, K. E.
- Venue
- Nature Communications
- Published
- 2018-07-13
- Volume
- 9
- Issue
- 1
- Pages
- 2703-2703
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2783961388
- Cited by
- 348
- References
- 89
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lam, M. M. C., Wyres, K. L., Duchêne, S., Wick, R. R., Judd, L. M., Gan, Y.-H., Hoh, C.-H., Archuleta, S., Molton, J. S., Kalimuddin, S., Koh, T. H., Passet, V., Brisse, S., & Holt, K. E. (2018). Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination. Nature Communications. https://doi.org/10.1038/s41467-018-05114-7
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