The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment
Open accessAbstract
Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhibit ideal size and charge for drug transportation. In tumour microenvironment, pPhD NPs responsively transform to full API nanotheranostics with ultra-small size and higher surface charge, which dramatically facilitate the tumour penetration and cell internalisation. pPhD NPs enable visualisation of biodistribution by near-infrared fluorescence imaging, tumour accumulation and therapeutic effect by magnetic resonance imaging. Moreover, the synergistic photothermal-, photodynamic- and chemo-therapies achieve a 100% complete cure rate on both subcutaneous and orthotopic oral cancer models. This nanoplatform with powerful delivery efficiency and versatile theranostic functions shows enormous potentials to improve cancer treatment.
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Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
Drug combination studies and their synergy quantification using the Chou-Talalay method
Chou, T.-C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1947 · Cited by 5,739
Maeda, H. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00013-3 · Cited by 2,495
Combination cancer immunotherapies tailored to the tumour microenvironment
Smyth, M. J., Ngiow, S. F., Ribas, A., & Teng, M. W. L. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.209 · Cited by 944
Cited by
Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Precise nanomedicine for intelligent therapy of cancer
Chen, H., Gu, Z., An, H., Chen, C., Chen, J., Cui, R., Chen, S., Chen, W., Chen, X., Chen, X., et al. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9397-5 · Cited by 409
Self-citationStimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics
Wei, D., Sun, Y., Zhu, H., & Fu, Q. (2023) · ACS Nano · doi:10.1021/acsnano.3c06019 · Cited by 303
Liu, J., Liu, J., Mu, W., Ma, Q., Zhai, X., Jin, B., Liu, Y., & Zhang, N. (2024) · ACS Nano · doi:10.1021/acsnano.4c02380 · Cited by 74
Sun, Y., Liang, Y., Hao, N., Fu, X., He, B., Han, S., Cao, J., Ma, Q., Xu, W., & Sun, Y. (2020) · Nanoscale · doi:10.1039/c9nr10574c · Cited by 60
Metadata
- Authors
- Xue, X., Huang, Y., Bo, R., Jia, B., Wu, H., Yuan, Y., Wang, Z., Ma, Z., Jing, D., Xu, X., Yu, W., Lin, T.-Y., & Li, Y.
- Venue
- Nature Communications
- Published
- 2018-09-07
- Volume
- 9
- Issue
- 1
- Pages
- 3653-3653
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2891498491
- Cited by
- 198
- References
- 4
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xue, X., Huang, Y., Bo, R., Jia, B., Wu, H., Yuan, Y., Wang, Z., Ma, Z., Jing, D., Xu, X., Yu, W., Lin, T.-Y., & Li, Y. (2018). Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment. Nature Communications. https://doi.org/10.1038/s41467-018-06093-5
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