Cited by 2,495Nanoparticle-Based Drug DeliveryBarrier Structure and Function StudiesAngiogenesis and VEGF in Cancer

The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting

Maeda, Hiroshi·2001·Advances in Enzyme Regulation

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Registry

Crossref · 10.1016/s0065-2571(00)00013-3

Cites

55 of 55 references verified0 citation errors · 0 not checkable

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  • HA-CD:catalase mass ratio of 3:1 was chosen for further studies because the obtained HA-CAT had a reasonable hydrodynamic diameter suitable for tumor accumulation and better retained catalase activity.

    “HA-CD:catalase mass ratio of 3:1 was eventually chosen for further studies, since the obtained HA-CAT has a reasonable hydrodynamic diameter suitable for the accumulation in tumor 48 and better retained activity of catalase (Figure S5 and Table S1).”

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Authors
Maeda, H.
Affiliations
Kumamoto University (JP)
Corresponding author
Maeda, Hiroshi
Venue
Advances in Enzyme Regulation
Publisher
Elsevier BV
Published
2001-05
Volume
41
Issue
1
Pages
189-207
ISSN
0065-2571 (ISSN-L)
OpenAlex
W2037048276
Cited by
2,495
References
55
Citations by year
2026: 46 · 2025: 83 · 2024: 82 · 2023: 87 · 2022: 101 · 2021: 108 · 2020: 123 · 2019: 130 · 2018: 154 · 2017: 134 · 2016: 164 · 2015: 161 · 2014: 168 · 2013: 207 · 2012: 151
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Advances in Enzyme Regulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
enhanced permeability and retention effect, tumor vasculature, tumor-selective drug delivery, tumor angiogenesis
MeSH terms
Animals, Blood Pressure, Carcinoma, Hepatocellular, Humans, Liver, Liver Neoplasms, Models, Biological, Neoplasms, Permeability, Polymers, Time Factors, Tissue Distribution, Veins, Drug Delivery Systems, Area Under Curve

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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