The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HA-CD:catalase mass ratio of 3:1 was chosen for further studies because the obtained HA-CAT had a reasonable hydrodynamic diameter suitable for tumor accumulation and better retained catalase activity.
“HA-CD:catalase mass ratio of 3:1 was eventually chosen for further studies, since the obtained HA-CAT has a reasonable hydrodynamic diameter suitable for the accumulation in tumor 48 and better retained activity of catalase (Figure S5 and Table S1).”
From Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor (2019) · cites this paper as [48]
Cites
Tumor angiogenesis: therapeutic implications
Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187 · see citing works
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works
Self-citationTumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works
Self-citationVascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 4,988 · see citing works
Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid
Senger, D. R., Galli, S. J., Dvořàk, A. M., Perruzzi, C. A., Harvey, V. S., & Dvorak, H. F. (1983) · Science · doi:10.1126/science.6823562 · Cited by 3,969 · see citing works
Folkman, J., & Shing, Y. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49853-0 · Cited by 2,651 · see citing works
Ferrara, N., & Henzel, W. J. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92678-8 · Cited by 2,269 · see citing works
Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF
Keck, P. J., Hauser, S. D., Krivi, G. G., Sanzo, K., Warren, T. G., Feder, J., & Connolly, D. T. (1989) · Science · doi:10.1126/science.2479987 · Cited by 2,058 · see citing works
The codependence of angiogenesis and chronic inflammation
Jackson, J. R., Seed, M. P., Kircher, C. H., Willoughby, D. A., & Winkler, J. D. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.6.9194526 · Cited by 690 · see citing works
Vasey, P. A., Kaye, S. B., Morrison, R. A., Twelves, C. J., Wilson, P., Duncan, R., Thomson, A. H., Murray, L. S., Hilditch, T. E., Murray, T., et al. (1999) · PubMed · Cited by 689 · see citing works
Tumoritropic and lymphotropic principles of macromolecular drugs.
Maeda, H., & Matsumura, Y. (1989) · PubMed · Cited by 579 · see citing works
Self-citationConjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo
Maeda, H., Seymour, L. W., & Miyamoto, Y. (1992) · Bioconjugate Chemistry · doi:10.1021/bc00017a001 · Cited by 563 · see citing works
Self-citationNoguchi, Y., Wu, J., Duncan, R., Strohalm, J., Ulbrich, K., Akaike, T., & Maeda, H. (1998) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1998.tb00563.x · Cited by 470 · see citing works
Self-citationRole of nitric oxide in angiogenesis and tumor progression in head and neck cancer
Gallo, O., Fini-Storchi, I., Vergari, W. A., Masini, E., Morbidelli, L., Ziche, M., & Franchi, A. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.8.587 · Cited by 427 · see citing works
Lynch, H. T., Kimberling, W. J., Albano, W. A., Lynch, J. F., Biscone, K. A., Schuelke, G. S., Sandberg, A. A., Lipkin, M., Deschner, E. E., Mikol, Y. B., et al. (1985) · Cancer · doi:10.1002/1097-0142(19850815)56:4 · Cited by 402 · see citing works
Konno, T., Maeda, H., Iwai, K., Tashiro, S., Maki, S., Morinaga, T., Mochinaga, M., Hiraoka, T., & Yokoyama, I. (1983) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(83)90028-7 · Cited by 342 · see citing works
Self-citationSeymour, L. W., Miyamoto, Y., Maeda, H., Brereton, M., Strohalm, J., Ulbrich, K., & Duncan, R. (1995) · European Journal of Cancer · doi:10.1016/0959-8049(94)00514-6 · Cited by 337 · see citing works
Self-citationIwai, K., Maeda, H., & Konno, T. (1984) · PubMed · Cited by 284 · see citing works
Self-citationSuzuki, M., Hori, K., Abe, I., Saito, S., & Sato, H. (1981) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/67.3.663 · Cited by 268 · see citing works
Asano, M., Yukita, A., Matsumoto, T., et al. (1995) · PubMed · Cited by 260 · see citing works
Inactivation of .alpha.1-proteinase inhibitor by peroxynitrite
Moreno, J. J., & Pryor, W. A. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00027a017 · Cited by 250 · see citing works
Maeda, H., Ueda, M., Morinaga, T., & Matsumoto, T. (1985) · Journal of Medicinal Chemistry · doi:10.1021/jm00382a012 · Cited by 225 · see citing works
Self-citationOkamoto, T., Akaike, T., Nagano, T., Miyajima, S., Suga, M., Ando, M., Ichimori, K., & Maeda, H. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0127 · Cited by 224 · see citing works
Self-citationMaeda, H., Noguchi, Y., Sato, K., & Akaike, T. (1994) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1994.tb02362.x · Cited by 221 · see citing works
Self-citationSMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy
Maeda, H. (1991) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(91)90040-j · Cited by 214 · see citing works
Self-citationWu, J., Akaike, T., & Maeda, H. (1998) · PubMed · Cited by 212 · see citing works
Self-citationMicrovascular architecture of experimental colon tumors in the rat.
Skinner, S. A., Tutton, P. J. M., & O’Brien, P. E. (1990) · PubMed · Cited by 179 · see citing works
Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue
Matsumura, Y., Kimura, M., Yamamoto, T., & Maeda, H. (1988) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1988.tb01563.x · Cited by 163 · see citing works
Self-citationMAEDA, H., Takeshita, J., & Kanamaru, R. (1979) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1979.tb01730.x · Cited by 157 · see citing works
Self-citationEnhanced Vascular Permeability in Solid Tumor Involving Peroxynitrite and Matrix Metalloproteinases
Wu, J., Akaike, T., Hayashida, K., Okamoto, T., Okuyama, A., & Maeda, H. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb01114.x · Cited by 152 · see citing works
Self-citationMaeda, H., Matsumura, Y., & Kato, H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37555-0 · Cited by 128 · see citing works
Self-citationMechanisms of localization of gallium-67 in tumors
Larson, S. M. (1978) · Seminars in Nuclear Medicine · doi:10.1016/s0001-2998(78)80028-2 · Cited by 126 · see citing works
Muggia, F. M. (1999) · PubMed · Cited by 122 · see citing works
Microvessel quantification and its possible relation with liver metastasis in colorectal cancer
Tomisaki, S., Ohno, S., Ichiyoshi, Y., Kuwano, H., Maehara, Y., & Sugimachi, K. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960415)77:8 · Cited by 118 · see citing works
Tailor-making of protein drugs by polymer conjugation for tumor targeting: A brief review on smancs
Maeda, H., Matsumoto, T., Konno, T., Iwai, K., & Ueda, M. (1984) · Journal of Protein Chemistry · doi:10.1007/bf01040499 · Cited by 115 · see citing works
Self-citationKinin‐generating Cascade in Advanced Cancer Patients and in vitro Study
Matsumura, Y., Maruo, K., Kimura, M., Yamamoto, T., Konno, T., & Maeda, H. (1991) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1991.tb01910.x · Cited by 104 · see citing works
Self-citationConditioned Medium from Mouse Sarcoma 180 Cells Contains Vascular Endothelial Growth Factor
Rosenthal, R. A., Megyesi, J. F., Henzel, W. J., Ferrara, N., & Folkman, J. (1990) · Growth Factors · doi:10.3109/08977199009011010 · Cited by 100 · see citing works
Li, C. J., Miyamoto, Y., Kojima, Y., & Maeda, H. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.179 · Cited by 96 · see citing works
Self-citationReichman, H. R., Farrell, C. L., & Maestro, R. F. D. (1986) · Journal of neurosurgery · doi:10.3171/jns.1986.65.2.0233 · Cited by 92 · see citing works
Maeda, H., Okamoto, T., & Akaike, T. (1998) · Biological Chemistry · doi:10.1515/bchm.1998.379.2.193 · Cited by 88 · see citing works
Self-citationKallikrein–kinin in infection and cancer
Maeda, H., Wu, J., Okamoto, T., Maruo, K., & Akaike, T. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00104-6 · Cited by 83 · see citing works
Self-citationKonno, T. (1992) · European Journal of Cancer · doi:10.1016/s0959-8049(05)80063-2 · Cited by 74 · see citing works
Is There a Role for Nitric Oxide in Tumor Angiogenesis?
García‐Cardeña, G., & Folkman, J. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.8.560 · Cited by 61 · see citing works
Maruo, K., Akaike, T., Ono, T., & Maeda, H. (1998) · Infection and Immunity · doi:10.1128/iai.66.2.866-869.1998 · Cited by 57 · see citing works
Self-citationTumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver.
Iwai, K., Maeda, H., Konno, T., et al. (1987) · PubMed · Cited by 49 · see citing works
Self-citationSakata, Y., Akaike, T., Suga, M., et al. (1996) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1996.tb01088.x · Cited by 48 · see citing works
Suzuki, M., Takahashi, T., & Sato, T. (1987) · Cancer · doi:10.1002/1097-0142(19870201)59:3 · Cited by 47 · see citing works
Hori, K., Saito, S., Takahashi, H., Sato, H., Maeda, H., & Sato, Y. (2000) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2000.tb00940.x · Cited by 45 · see citing works
Self-citationTsuchiya, K., Uchida, T., Kobayashi, M., et al. (2000) · Urology · doi:10.1016/s0090-4295(99)00537-3 · Cited by 43 · see citing works
Maeda, H., & Konno, T. (1997) · Springer eBooks · doi:10.1007/978-4-431-66914-2_12 · Cited by 35 · see citing works
Self-citationDrug Targeting in Cancer Therapy: The Magic Bullet, What Next?
Duncan, R., Connors, T. A., & Meada, H. (1996) · Journal of drug targeting · doi:10.3109/10611869608996823 · Cited by 31 · see citing works
Drug Targeting in Cancer Therapy
Poste, G. H. (1984) · Springer eBooks · doi:10.1007/978-1-4684-4862-7_25 · Cited by 28 · see citing works
Kojima, Y., Akaike, T., Sato, K., et al. (1996) · Journal of Bioactive and Compatible Polymers · doi:10.1177/088391159601100301 · Cited by 26 · see citing works
Targeting Chemotherapy of Hepatocellular Carcinoma
Konno, T., & Maeda, H. (1987) · Springer eBooks · doi:10.1007/978-4-431-68349-0_27 · Cited by 22 · see citing works
Self-citationBryan (1984) · doi:10.1002/1097-0142(19841201)54:11
Flagged first, then by citations
Cited by
Sorted by citations
Factors affecting the clearance and biodistribution of polymeric nanoparticles
Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699 · see citing works
Maeda, H., Nakamura, H., & Fang, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.002 · Cited by 2,376 · see citing works
Self-citationEngineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164 · see citing works
Wu, J. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11080771 · Cited by 1,030 · see citing works
Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery
Rapoport, N. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.009 · Cited by 1,002 · see citing works
Kobayashi, H., Watanabe, R., & Choyke, P. L. (2014) · Theranostics · doi:10.7150/thno.7193 · Cited by 996 · see citing works
Advances in polymeric micelles for drug delivery and tumor targeting
Kedar, U., Phutane, P., Shidhaye, S., & Kadam, V. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2010.05.005 · Cited by 791 · see citing works
Fang, J., Islam, W., & Maeda, H. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.005 · Cited by 757 · see citing works
Self-citationA review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics
Steichen, S. D., Caldorera-Moore, M., & Peppas, N. A. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.12.006 · Cited by 751 · see citing works
Pharmacokinetic aspects of retinal drug delivery
del Amo, E. M., Rimpelä, A.-K., Heikkinen, E., Kari, O. K., Ramsay, E., Lajunen, T., Schmitt, M., Pelkonen, L., Bhattacharya, M., Richardson, D., et al. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.12.001 · Cited by 693 · see citing works
Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
Torchilin, V. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.026 · Cited by 583 · see citing works
Mechanisms of drug release in nanotherapeutic delivery systems
Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507 · see citing works
Polymeric nanomedicine for cancer therapy
Park, J. H., Lee, S., Kim, J.-H., Park, K., Kim, K., & Kwon, I. C. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.09.003 · Cited by 506 · see citing works
Uchino, H., Matsumura, Y., Negishi, T., Koizumi, F., Hayashi, T., Honda, T., Nishiyama, N., Kataoka, K., Naito, S., & Kakizoe, T. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602772 · Cited by 430 · see citing works
Plummer, R., Wilson, R. H., Calvert, H., Boddy, A. V., Griffin, M., Sludden, J., Tilby, M. J., Eatock, M., Pearson, D. G., Ottley, C. J., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.6 · Cited by 390 · see citing works
Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor
Phua, S. Z. F., Yang, G., Lim, W. Q., Verma, A., Chen, H., Thanabalu, T., & Zhao, Y. (2019) · ACS Nano · doi:10.1021/acsnano.9b01087 · Cited by 375 · see citing works
Role of integrated cancer nanomedicine in overcoming drug resistance
Iyer, A. K., Singh, A., Ganta, S., & Amiji, M. M. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.012 · Cited by 343 · see citing works
Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy
Gindy, M. E., & Prud'homme, R. K. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902932908 · Cited by 298 · see citing works
Smith, A., Giunta, B., Bickford, P. C., Fountain, M., Tan, J., & Shytle, R. D. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.01.012 · Cited by 280 · see citing works
Polymer micelles with cross-linked polyanion core for delivery of a cationic drug doxorubicin
Kim, J. O., Kabanov, A. V., & Bronich, T. K. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.04.019 · Cited by 255 · see citing works
Biodegradable, polymeric nanoparticle delivery systems for cancer therapy
Pridgen, E. M., Langer, R., & Farokhzad, O. C. (2007) · Nanomedicine · doi:10.2217/17435889.2.5.669 · Cited by 249 · see citing works
Jia, X., Zhang, Y., Zou, Y., Wang, Y., Niu, D., He, Q., Huang, Z., Zhu, W., Tian, H., Shi, J., et al. (2018) · Advanced Materials · doi:10.1002/adma.201704490 · Cited by 232 · see citing works
Xin, L., Gao, J., Zheng, Z., Chen, Y., Lv, S., Zhao, Z., Yu, C., Yang, X., & Zhang, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.648187 · Cited by 203 · see citing works
Maeda, H. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030229 · Cited by 167 · see citing works
Self-citationBlanco, E., Bey, E. A., Dong, Y., Weinberg, B. D., Sutton, D. M., Boothman, D. A., & Gao, J. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.04.014 · Cited by 165 · see citing works
Lipid nanoparticles for short interfering RNA delivery
Leung, A. K. K., Tam, Y. Y. C., & Cullis, P. R. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800148-6.00004-3 · Cited by 158 · see citing works
Liu, J., Zeng, F., & Allen, C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.013 · Cited by 139 · see citing works
The Fluid Mechanics of Cancer and Its Therapy
Koumoutsakos, P., Pivkin, I., & Milde, F. (2013) · Annual Review of Fluid Mechanics · doi:10.1146/annurev-fluid-120710-101102 · Cited by 129 · see citing works
Watanabe, M., Kawano, K., Yokoyama, M., Opanasopit, P., Okano, T., & Maitani, Y. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.030 · Cited by 128 · see citing works
Polyethylene glycol: A promising approach for sustainable organic synthesis
Soni, J., Sahiba, N., Sethiya, A., & Agarwal, S. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.113766 · Cited by 107 · see citing works
Ho, Y. T., Kamm, R. D., & Kah, J. C. Y. (2018) · Nanoscale · doi:10.1039/c8nr02393j · Cited by 102 · see citing works
Badea, C. T., Clark, D. P., Holbrook, M., Srivastava, M., Mowery, Y., & Ghaghada, K. B. (2019) · Physics in Medicine & Biology · doi:10.1088/1361-6560/ab03e2 · Cited by 74 · see citing works
Nanodelivery Systems for Nucleic Acid Therapeutics in Drug Resistant Tumors
Iyer, A. K., Duan, Z., & Amiji, M. M. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500024p · Cited by 55 · see citing works
NIR‐II Emissive Ru(II) Metallacycle Assisting Fluorescence Imaging and Cancer Therapy
Fan, Y., Li, C., Bai, S., Ma, X., Yang, J., Guan, X., & Sun, Y. (2022) · Small · doi:10.1002/smll.202201625 · Cited by 51 · see citing works
Xu, Y., Dou, Y., Li, Q., Ye, H., Li, Y., Qiu, S., Xiong, X., Li, J., & Sun, Y. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215320 · Cited by 39 · see citing works
Liposomal glutathione as a promising candidate for immunological rheumatoid arthritis therapy
Kadry, M. O. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02162 · Cited by 29 · see citing works
EGF-liposomes promote efficient EGFR targeting in xenograft colocarcinoma model
Zalba, S., Contreras, A. M., Merino, M., Navarro, I., de Ilarduya, C. T., Trocóniz, I. F., Koning, G., & Garrido, M. J. (2016) · Nanomedicine · doi:10.2217/nnm.15.208 · Cited by 26 · see citing works
Cong, Z., Yang, F., Cao, L., Wen, H., Fu, T., Ma, S., Liu, C., Quan, L., & Liao, Y. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s185726 · Cited by 23 · see citing works
CPX-351 in acute myeloid leukemia: can a new formulation maximize the efficacy of old compounds?
Brunetti, C., Anelli, L., Zagaria, A., Specchia, G., & Albano, F. (2017) · Expert Review of Hematology · doi:10.1080/17474086.2017.1369400 · Cited by 23 · see citing works
Boghaert, E. R., Cox, M. C., & Vaidya, K. S. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3236 · Cited by 17 · see citing works
- Authors
- Maeda, H.
- Affiliations
- Kumamoto University (JP)
- Corresponding author
- Maeda, Hiroshi
- ORCID
- Maeda, Hiroshi
- Venue
- Advances in Enzyme Regulation
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 41
- Issue
- 1
- Pages
- 189-207
- ISSN
- 0065-2571 (ISSN-L)
- OpenAlex
- W2037048276
- Cited by
- 2,495
- References
- 55
- Citations by year
- 2026: 46 · 2025: 83 · 2024: 82 · 2023: 87 · 2022: 101 · 2021: 108 · 2020: 123 · 2019: 130 · 2018: 154 · 2017: 134 · 2016: 164 · 2015: 161 · 2014: 168 · 2013: 207 · 2012: 151
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advances in Enzyme Regulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- enhanced permeability and retention effect, tumor vasculature, tumor-selective drug delivery, tumor angiogenesis
- MeSH terms
- Animals, Blood Pressure, Carcinoma, Hepatocellular, Humans, Liver, Liver Neoplasms, Models, Biological, Neoplasms, Permeability, Polymers, Time Factors, Tissue Distribution, Veins, Drug Delivery Systems, Area Under Curve
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review