The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Chromatin swelling drives neutrophil extracellular trap release
Open accessAbstract
Neutrophilic granulocytes are able to release their own DNA as neutrophil extracellular traps (NETs) to capture and eliminate pathogens. DNA expulsion (NETosis) has also been documented for other cells and organisms, thus highlighting the evolutionary conservation of this process. Moreover, dysregulated NETosis has been implicated in many diseases, including cancer and inflammatory disorders. During NETosis, neutrophils undergo dynamic and dramatic alterations of their cellular as well as sub-cellular morphology whose biophysical basis is poorly understood. Here we investigate NETosis in real-time on the single-cell level using fluorescence and atomic force microscopy. Our results show that NETosis is highly organized into three distinct phases with a clear point of no return defined by chromatin status. Entropic chromatin swelling is the major physical driving force that causes cell morphology changes and the rupture of both nuclear envelope and plasma membrane. Through its material properties, chromatin thus directly orchestrates this complex biological process.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Novel cell death program leads to neutrophil extracellular traps
Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309
Neutrophil extracellular traps: Is immunity the second function of chromatin?
Brinkmann, V., & Zychlinsky, A. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201203170 · Cited by 1,021
Localization of the primary metabolic block produced by 2-deoxyglucose
Wick, A. N., Drury, D. R., Nakada, H. I., Wolfe, J. B., Britton, B., & Grabowski, R. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64988-9 · Cited by 780
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Kolaczkowska, E., Jenne, C. N., Surewaard, B. G. J., Thanabalasuriar, A., Lee, W.-Y., Sanz, M.-J., Mowen, K., Opdenakker, G., & Kubes, P. (2015) · Nature Communications · doi:10.1038/ncomms7673 · Cited by 584
Energy Metabolism of Human Neutrophils during Phagocytosis
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Cited by
Teijeira, Á., Garasa, S., Gato, M., Alfaro, C., Migueliz, I., Cirella, A., de Andrea, C., Ochoa, M. C., Otano, I., Etxeberria, I., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.001 · Cited by 788
Biosensing with Fluorescent Carbon Nanotubes
Ackermann, J., Metternich, J. T., Herbertz, S., & Kruss, S. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202112372 · Cited by 280
Self-citationOber-Reynolds, B., Wang, C., Ko, J. M., Rios, E. J., Aasi, S. Z., Davis, M. M., Oro, A. E., & Greenleaf, W. J. (2023) · Nature Genetics · doi:10.1038/s41588-023-01445-4 · Cited by 83
Polystyrene Nanoplastics Induce Neutrophil Extracellular Traps in Mice Neutrophils
Zhu, X., Peng, L., Song, E., & Song, Y. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00374 · Cited by 36
Neutrophil Extracellular Traps: Inflammation and Biomaterial Preconditioning for Tissue Engineering
Fetz, A. E., & Bowlin, G. L. (2022) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2021.0013 · Cited by 36
Metadata
- Authors
- Neubert, E., Meyer, D., Rocca, F., Günay, G., Kwaczala-Tessmann, A., Grandke, J., Senger-Sander, S., Geisler, C., Egner, A., Schön, M. P., Erpenbeck, L., & Kruss, S.
- Venue
- Nature Communications
- Published
- 2018-09-14
- Volume
- 9
- Issue
- 1
- Pages
- 3767-3767
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2890771157
- Cited by
- 238
- References
- 8
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- gold
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- Neubert, E., Meyer, D., Rocca, F., Günay, G., Kwaczala-Tessmann, A., Grandke, J., Senger-Sander, S., Geisler, C., Egner, A., Schön, M. P., Erpenbeck, L., & Kruss, S. (2018). Chromatin swelling drives neutrophil extracellular trap release. Nature Communications. https://doi.org/10.1038/s41467-018-06263-5
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