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Cited by 1,021Neutrophil, Myeloperoxidase and Oxidative MechanismsAntimicrobial Peptides and ActivitiesBlood disorders and treatments

Neutrophil extracellular traps: Is immunity the second function of chromatin?

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Brinkmann, Volker, Zychlinsky, Arturo·2012·Journal of Cell Biology
DOI 10.1083/jcb.201203170PMC PMC3432757
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Abstract

Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular and selected cytoplasmic proteins. NETs are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections. This release of chromatin is the result of a unique form of cell death, dubbed "NETosis." Here we review our understanding of how NETs are made, their function in infections and as danger signals, and their emerging importance in autoimmunity and coagulation.

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  • Dental calculus is primarily a calcified microbial biofilm.

    “The biological content of dental calculus is primarily microbial in origin (Warinner et al., 2014b)”

    From Successful enrichment and recovery of whole mitochondrial genomes from ancient human dental calculus (2016) · cites this paper as Brinkmann and Zychlinsky, 2012

    The Periodontitis section discusses bacteria in the gingival crevice and neutrophil extracellular traps, but not dental calculus. Searches for dental calculus, calcified biofilm, and microbial composition found no passage in our copy addressing the claim. The printed sentence cites Warinner et al. (2014b), not this source. (LLM, conf=0.75)

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Cited by

Sorted by citations

Authors
Brinkmann, V., & Zychlinsky, A.
Affiliations
  • Max Planck Society (DE)
  • Max Planck Institute for Infection Biology (DE)
Corresponding author
  • Brinkmann, Volker
  • Zychlinsky, Arturo
ORCID
Venue
Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2012-09-03
Volume
198
Issue
5
Pages
773-783
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.201203170
PMC
PMC3432757
OpenAlex
W2030193400
Cited by
1,021
References
6
Citations by year
2026: 39 · 2025: 38 · 2024: 48 · 2023: 84 · 2022: 58 · 2021: 89 · 2020: 79 · 2019: 73 · 2018: 73 · 2017: 95 · 2016: 115 · 2015: 82 · 2014: 85 · 2013: 57 · 2012: 6
FWCI
6.79
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • The Journal of Cell Biology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
Keywords
neutrophil extracellular traps, NETosis, chromatin, neutrophils, innate immunity, microbial infection, damage-associated molecular patterns, autoimmunity, coagulation, cell death
MeSH terms
Animals, Chromatin, Humans, Infections, Neutrophils, Autoimmunity, Cell Death, Neutrophil Activation

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