The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements
Open accessAbstract
The infant gut microbiota has a high abundance of antibiotic resistance genes (ARGs) compared to adults, even in the absence of antibiotic exposure. Here we study potential sources of infant gut ARGs by performing metagenomic sequencing of breast milk, as well as infant and maternal gut microbiomes. We find that fecal ARG and mobile genetic element (MGE) profiles of infants are more similar to those of their own mothers than to those of unrelated mothers. MGEs in mothers’ breast milk are also shared with their own infants. Termination of breastfeeding and intrapartum antibiotic prophylaxis of mothers, which have the potential to affect microbial community composition, are associated with higher abundances of specific ARGs, the composition of which is largely shaped by bacterial phylogeny in the infant gut. Our results suggest that infants inherit the legacy of past antibiotic consumption of their mothers via transmission of genes, but microbiota composition still strongly impacts the overall resistance load.
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Cited by
Karkman, A., Pärnänen, K., & Larsson, D. G. J. (2019) · Nature Communications · doi:10.1038/s41467-018-07992-3 · Cited by 628
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Understanding the impact of antibiotic perturbation on the human microbiome
Schwartz, D. J., Langdon, A. E., & Dantas, G. (2020) · Genome Medicine · doi:10.1186/s13073-020-00782-x · Cited by 322
Maternal vertical transmission affecting early-life microbiota development
Wang, S., Ryan, C. A., Boyaval, P., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2019.07.010 · Cited by 243
Good microbes, bad genes? The dissemination of antimicrobial resistance in the human microbiome
Crits-Christoph, A., Hallowell, H. A., Koutouvalis, K., & Suez, J. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2055944 · Cited by 156
Metadata
- Authors
- Pärnänen, K., Karkman, A., Hultman, J., Lyra, C., Bengtsson-Palme, J., Larsson, D. G. J., Rautava, S., Isolauri, E., Salminen, S., Kumar, H., Satokari, R., & Virta, M.
- Venue
- Nature Communications
- Published
- 2018-09-24
- Volume
- 9
- Issue
- 1
- Pages
- 3891-3891
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2890924527
- Cited by
- 678
- References
- 61
- FWCI
- 11.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pärnänen, K., Karkman, A., Hultman, J., Lyra, C., Bengtsson-Palme, J., Larsson, D. G. J., Rautava, S., Isolauri, E., Salminen, S., Kumar, H., Satokari, R., & Virta, M. (2018). Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements. Nature Communications. https://doi.org/10.1038/s41467-018-06393-w
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