Maternal vertical transmission affecting early-life microbiota development
Abstract
The association of the human microbiome with health outcomes has attracted much interest toward its therapeutic manipulation. The likelihood of modulating the human microbiome in early life is high and offers great potential to exert profound effects on human development since the early microbiota shows more flexibility compared to that of adults. The human microbiota, being similar to human genetics, can be transmitted from mother to infant, providing insights into early microbiota acquisition, subsequent development, and potential opportunities for intervention. Here, we review adaptations of the maternal microbiota during pregnancy, birth, and infancy, the acquisition and succession of early-life microbiota, and highlight recent efforts to elucidate mother-to-infant microbiota transmission. We further discuss how the mother-to-infant microbial transmission is shaped; and finally we address potential directions for future studies to promote our understanding within this field.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several factors are known to influence microbial composition at different stages of life, including genetic factors, mode of delivery, gestational age, exercise, medication use, living environment, and diet.
“Several factors are known to influence microbial composition at different stages of life, including genetic factors, mode of delivery [vaginal birth or Caesarean section (C-section)], gestational age, exercise, medication use, living environment, and diet (237-240).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [240]
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works
Vaginal microbiome of reproductive-age women
Ravel, J., Gajer, P., Abdo, Z., Schneider, G. M., Koenig, S. S. K., McCulle, S. L., Karlebach, S., Gorle, R., Russell, J., Tacket, C. O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002611107 · Cited by 4,254 · see citing works
Evolution of mammals and their gut microbes
Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747 · see citing works
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315 · see citing works
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164 · see citing works
The Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494 · see citing works
The Increasing Trend in Caesarean Section Rates: Global, Regional and National Estimates: 1990-2014
Betrán, A. P., Ye, J., Moller, A.-B., Zhang, J., Gülmezoglu, A. M., & Torloni, M. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148343 · Cited by 2,250 · see citing works
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232 · see citing works
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165 · see citing works
Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans
Sender, R., Fuchs, S., & Milo, R. (2016) · Cell · doi:10.1016/j.cell.2016.01.013 · Cited by 2,050 · see citing works
Temporal development of the gut microbiome in early childhood from the TEDDY study
Stewart, C. J., Ajami, N. J., O’Brien, J. L., Hutchinson, D. S., Smith, D. P., Wong, M. C., Ross, M. C., Lloyd, R. E., Doddapaneni, H., Metcalf, G., et al. (2018) · Nature · doi:10.1038/s41586-018-0617-x · Cited by 1,996 · see citing works
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950 · see citing works
Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016) · Genome Medicine · doi:10.1186/s13073-016-0307-y · Cited by 1,891 · see citing works
Temporal Dynamics of the Human Vaginal Microbiota
Gajer, P., Brotman, R. M., Bai, G., Sakamoto, J. M., Schütte, U. M. E., Zhong, X., Koenig, S. S. K., Fu, L., Ma, Z. S., Zhou, X., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003605 · Cited by 1,552 · see citing works
Antibiotics, birth mode, and diet shape microbiome maturation during early life
Bokulich, N. A., Chung, J., Battaglia, T., Henderson, N., Jay, M., Li, H., D. Lieber, A., Wu, F., Perez-Perez, G. I., Chen, Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7121 · Cited by 1,469 · see citing works
Developmental microbial ecology of the neonatal gastrointestinal tract
Mackie, R. I., Sghir, A., & Gaskins, H. R. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.1035s · Cited by 1,360 · see citing works
Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation
Browne, H. P., Forster, S. C., Anonye, B. O., Kumar, N., Neville, B. A., Stares, M. D., Goulding, D., & Lawley, T. D. (2016) · Nature · doi:10.1038/nature17645 · Cited by 1,299 · see citing works
Ferretti, P., Pasolli, E., Tett, A., Asnicar, F., Gorfer, V., Fedi, S., Armanini, F., Truong, D. T., Manara, S., Zolfo, M., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.06.005 · Cited by 1,292 · see citing works
The microbiome in early life: Implications for health outcomes
Tamburini, S., Shen, N., Wu, H. C., & Clemente, J. C. (2016) · Nature Medicine · doi:10.1038/nm.4142 · Cited by 1,213 · see citing works
Temporal and spatial variation of the human microbiota during pregnancy
DiGiulio, D. B., Callahan, B. J., McMurdie, P. J., Costello, E. K., Lyell, D. J., Robaczewska, A., Sun, C. L., Goltsman, D. S. A., Wong, R. J., Shaw, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502875112 · Cited by 1,129 · see citing works
Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096 · see citing works
Pannaraj, P. S., Li, F., Cerini, C., Bender, J. M., Yang, S., Rollie, A., Adisetiyo, H., Zabih, S., Lincez, P. J., Bittinger, K. L., et al. (2017) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.0378 · Cited by 1,066 · see citing works
Chu, D. M., Ma, J., Prince, A. L., Antony, K. M., Seferovic, M. D., & Aagaard, K. M. (2017) · Nature Medicine · doi:10.1038/nm.4272 · Cited by 1,063 · see citing works
Yassour, M., Vatanen, T., Siljander, H., Hämäläinen, A.-M., Härkönen, T., Ryhänen, S. J., Franzosa, E. A., Vlamakis, H., Huttenhower, C., Gevers, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0917 · Cited by 1,043 · see citing works
Group B Streptococcal Disease in the Era of Intrapartum Antibiotic Prophylaxis
Schrag, S. J., Zywicki, S., Farley, M. M., Reingold, A. L., Harrison, L. H., Lefkowitz, L. B., Hadler, J. L., Danila, R., Cieslak, P. R., & Schuchat, A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200001063420103 · Cited by 1,019 · see citing works
Jakobsson, H. E., Abrahamsson, T. R., Jenmalm, M. C., Harris, K., Quince, C., Jernberg, C., Björkstén, B., Engstrand, L., & Andersson, A. F. (2014) · Gut · doi:10.1136/gutjnl-2012-303249 · Cited by 1,011 · see citing works
The infant microbiome development: Mom matters
Mueller, N. T., Bakacs, E., Combellick, J., Grigoryan, Z., & Dominguez-Bello, M. G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.002 · Cited by 943 · see citing works
The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
Vatanen, T., Franzosa, E. A., Schwager, R., Tripathi, S. M., Arthur, T. D., Vehik, K., Lernmark, Å., Hagopian, W., Rewers, M., She, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0620-2 · Cited by 895 · see citing works
Cabrera-Rubio, R., Collado, M. C., Laitinen, K., Salminen, S., Isolauri, E., & Mira, A. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.037382 · Cited by 886 · see citing works
Recovery of gut microbiota of healthy adults following antibiotic exposure
Palleja, A., Mikkelsen, K. H., Forslund, S. K., Kashani, A., Allin, K. H., Nielsen, T., Hansen, T. H., Liang, S., Feng, Q., Zhang, C., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0257-9 · Cited by 875 · see citing works
Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women
Collado, M. C., Isolauri, E., Laitinen, K., & Salminen, S. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.894 · Cited by 863 · see citing works
Romero, R., Hassan, S. S., Gajer, P., Tarca, A. L., Fadrosh, D. W., Nikita, L., Galuppi, M., Lamont, R. F., Chaemsaithong, P., Miranda, J., et al. (2014) · Microbiome · doi:10.1186/2049-2618-2-4 · Cited by 852 · see citing works
Mom Knows Best: The Universality of Maternal Microbial Transmission
Funkhouser-Jones, L. J., & Bordenstein, S. R. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001631 · Cited by 795 · see citing works
The Human Microbiome and Child Growth – First 1000 Days and Beyond
Robertson, R. C., Manges, A. R., Finlay, B. B., & Prendergast, A. J. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2018.09.008 · Cited by 793 · see citing works
Pärnänen, K. M. M., Karkman, A., Hultman, J., Lyra, C., Bengtsson‐Palme, J., Larsson, D. G. J., Rautava, S., Isolauri, E., Salminen, S., Kumar, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06393-w · Cited by 682 · see citing works
Bacterial Imprinting of the Neonatal Immune System: Lessons From Maternal Cells?
Pérez, P. F., Dore, J. M., Leclerc, M., Levenez, F., Benyacoub, J., Serrant, P., Segura-Roggero, I., Schiffrin, E. J., & Donnet‐Hughes, A. (2007) · PEDIATRICS · doi:10.1542/peds.2006-1649 · Cited by 676 · see citing works
Complex Glycan Catabolism by the Human Gut Microbiota: The Bacteroidetes Sus-like Paradigm
Martens, E. C., Koropatkin, N. M., Smith, T. J., & Gordon, J. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.022848 · Cited by 657 · see citing works
Early life dynamics of the human gut virome and bacterial microbiome in infants
Lim, E. S., Zhou, Y., Zhao, G., Bauer, I. K., Droit, L., Ndao, I. M., Warner, B. B., Tarr, P. I., Wang, D., & Holtz, L. R. (2015) · Nature Medicine · doi:10.1038/nm.3950 · Cited by 644 · see citing works
Our gut microbiome: The evolving inner self
Kundu, P., Blacher, E., Elinav, E., & Pettersson, S. (2017) · Cell · doi:10.1016/j.cell.2017.11.024 · Cited by 633 · see citing works
Vertical mother–neonate transfer of maternal gut bacteria via breastfeeding
Jost, T., Lacroix, C., Braegger, C., Rochat, F., & Chassard, C. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12238 · Cited by 577 · see citing works
Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways
Marcobal, A., Barboza, M., Sonnenburg, E. D., Pudlo, N., Martens, E. C., Desai, P., Lebrilla, C. B., Weimer, B. C., Mills, D. A., German, J. B., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.007 · Cited by 574 · see citing works
Patterned progression of bacterial populations in the premature infant gut
Rosa, P. S. L., Warner, B. B., Zhou, Y., Weinstock, G. M., Sodergren, E. J., Hall-Moore, C. M., Stevens, H. J., Bennett, W. E., Shaikh, N., Linneman, L. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409497111 · Cited by 573 · see citing works
Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort
Hill, C. J., Lynch, D. B., Murphy, K., Ulaszewska, M., Jeffery, I. B., O’Shea, C. A., Watkins, C., Dempsey, E., Mattivi, F., Tuohy, K., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0213-y · Cited by 573 · see citing works
Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
Hsu, B. B., Gibson, T. E., Yeliseyev, V., Liu, Q., Lyon, L., Bry, L., Silver, P. A., & Gerber, G. K. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.001 · Cited by 573 · see citing works
Cospeciation of gut microbiota with hominids
Moeller, A. H., Caro‐Quintero, A., Mjungu, D. C., Georgiev, A. V., Lonsdorf, E. V., Muller, M. N., Pusey, A. E., Peeters, M., Hahn, B. H., & Ochman, H. (2016) · Science · doi:10.1126/science.aaf3951 · Cited by 570 · see citing works
The vaginal microbiome during pregnancy and the postpartum period in a European population
MacIntyre, D. A., Chandiramani, M., Lee, Y. S., Kindinger, L. M., Smith, A., Angelopoulos, N., Lehne, B. C., Arulkumaran, S., Brown, R., Teoh, T. G., et al. (2015) · Scientific Reports · doi:10.1038/srep08988 · Cited by 565 · see citing works
Lauder, A. P., Roche, A. M., Sherrill-Mix, S., Bailey, A., Laughlin, A. L., Bittinger, K., Leite, R., Elovitz, M. A., Parry, S., & Bushman, F. D. (2016) · Microbiome · doi:10.1186/s40168-016-0172-3 · Cited by 539 · see citing works
Development of intestinal microbiota in infants and its impact on health
Matamoros, S., Guen, C. G., Vacon, F. L., Potel, G., & de la Cochetière, M.-F. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2012.12.001 · Cited by 533 · see citing works
Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health
Petrova, M. I., Lievens, E., Malik, S., Imholz, N., & Lebeer, S. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00081 · Cited by 523 · see citing works
Human genetic variation and the gut microbiome in disease
Hall, A. B., Tolonen, A. C., & Xavier, R. J. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.63 · Cited by 517 · see citing works
Inhibition of Staphylococcus aureus by the commensal bacteria of human milk
Heikkilä, M., & Saris, P. E. J. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.02002.x · Cited by 501 · see citing works
Unraveling the processes shaping mammalian gut microbiomes over evolutionary time
Groussin, M., Mazel, F., Sanders, J. G., Smillie, C. S., Lavergne, S., Thuiller, W., & Alm, E. J. (2017) · Nature Communications · doi:10.1038/ncomms14319 · Cited by 491 · see citing works
Placental hormones and the control of maternal metabolism and fetal growth
Newbern, D., & Freemark, M. (2011) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e32834c800d · Cited by 487 · see citing works
Mother’s Milk: A purposeful contribution to the development of the infant microbiota and immunity
Le Doare, K., Holder, B., Bassett, A., & Pannaraj, P. S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00361 · Cited by 475 · see citing works
Healthy infants harbor intestinal bacteria that protect against food allergy
Feehley, T., Plunkett, C. H., Bao, R., Hong, S. M. C., Culleen, E., Belda‐Ferre, P., Campbell, E., Aitoro, R., Nocerino, R., Paparo, L., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0324-z · Cited by 474 · see citing works
Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides
Sela, D. A., & Mills, D. A. (2010) · Trends in Microbiology · doi:10.1016/j.tim.2010.03.008 · Cited by 468 · see citing works
Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome
Gibson, M. K., Wang, B., Ahmadi, S., Burnham, C.-A. D., Tarr, P. I., Warner, B. B., & Dantas, G. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.24 · Cited by 457 · see citing works
Rodríguez, J. M. (2014) · Advances in Nutrition · doi:10.3945/an.114.007229 · Cited by 456 · see citing works
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life
Yassour, M., Jason, E., Hogstrom, L. J., Arthur, T. D., Tripathi, S., Siljander, H., Selvenius, J., Oikarinen, S., Hyöty, H., Virtanen, S. M., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.06.007 · Cited by 455 · see citing works
Asnicar, F., Manara, S., Zolfo, M., Truong, D. T., Scholz, M., Armanini, F., Ferretti, P., Gorfer, V., Pedrotti, A., Tett, A., et al. (2017) · mSystems · doi:10.1128/msystems.00164-16 · Cited by 445 · see citing works
Ma, J., Prince, A., Bader, D., Hu, M., Ganu, R., Baquero, K. C., Blundell, P., Harris, R. A., Frias, A. E., Grove, K. L., et al. (2014) · Nature Communications · doi:10.1038/ncomms4889 · Cited by 440 · see citing works
Establishment and development of intestinal microbiota in preterm neonates
Arboleya, S., Binetti, A. G., Salazar, N., Fernández, N., Sánchez, G. S., Hernández‐Barranco, A. M., Margollés, A., Reyes‐Gavilán, C. G. D. L., & Gueimonde, M. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01261.x · Cited by 439 · see citing works
Collins, M. D., Samelis, J., Metaxopoulos, J., & Wallbanks, S. (1993) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1993.tb01600.x · Cited by 418 · see citing works
Murphy, K., Curley, D., O’Callaghan, T. F., O'Shea, C., Dempsey, E. M., O’Toole, P. W., Ross, R. P., Ryan, C. A., & Stanton, C. (2017) · Scientific Reports · doi:10.1038/srep40597 · Cited by 413 · see citing works
Human Intestinal Microflora in Health and Disease
(1983) · Elsevier eBooks · doi:10.1016/c2012-0-01555-4 · Cited by 395 · see citing works
The early infant gut microbiome varies in association with a maternal high-fat diet
Chu, D. M., Antony, K. M., Ma, J., Prince, A., Showalter, L., Moller, M., & Aagaard, K. M. (2016) · Genome Medicine · doi:10.1186/s13073-016-0330-z · Cited by 377 · see citing works
Diversity of microbes in amniotic fluid
DiGiulio, D. B. (2011) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2011.10.001 · Cited by 364 · see citing works
Jost, T., Lacroix, C., Braegger, C., & Chassard, C. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513000597 · Cited by 356 · see citing works
Dogra, S. K., Sakwińska, O., Soh, S., Ngom‐Bru, C., Brück, W. M., Berger, B. W., Brüssow, H., Lee, Y. S., Yap, F. K. P., Chong, Y. S., et al. (2015) · mBio · doi:10.1128/mbio.02419-14 · Cited by 348 · see citing works
Sharing of Bacterial Strains Between Breast Milk and Infant Feces
Martín, V., Maldonado‐Barragán, A., Moles, L., Rodríguez-Baños, M., del Campo, R., Fernández, L., Rodríguez, J. M., & Jiménez, E. (2012) · Journal of Human Lactation · doi:10.1177/0890334411424729 · Cited by 336 · see citing works
The gut microbiome, diet, and links to cardiometabolic and chronic disorders
Aron‐Wisnewsky, J., & Clément, K. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.191 · Cited by 327 · see citing works
Duranti, S., Lugli, G. A., Mancabelli, L., Armanini, F., Turroni, F., James, K., Ferretti, P., Gorfer, V., Ferrario, C., Milani, C., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0282-6 · Cited by 327 · see citing works
Selective maternal seeding and environment shape the human gut microbiomePreprint
Korpela, K., Costea, P. I., Coelho, L. P., Kandels-Lewis, S. E., Willemsen, G. A. H. M., Boomsma, D. I., Segata, N., & Peer Bork, B. (2018) · Genome Research · doi:10.1101/gr.233940.117 · Cited by 325 · see citing works
Fouhy, F., Clooney, A. G., Stanton, C., Claesson, M. J., & Cotter, P. D. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0738-z · Cited by 310 · see citing works
Impact of lactation stage, gestational age and mode of delivery on breast milk microbiota
Khodayar‐Pardo, P., Mira‐Pascual, L., Collado, M. C., & Martínez‐Costa, C. (2014) · Journal of Perinatology · doi:10.1038/jp.2014.47 · Cited by 302 · see citing works
Tun, H. M., Bridgman, S. L., Chari, R. S., Field, C. J., Guttman, D. S., Becker, A. B., Mandhane, P. J., Turvey, S. E., Subbarao, P., Sears, M. R., et al. (2018) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.5535 · Cited by 302 · see citing works
Li, H.-T., Zhou, Y.-B., & Liu, J.-M. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.195 · Cited by 301 · see citing works
Wampach, L., Heintz-Buschart, A., Fritz, J. V., Ramiro-Garcia, J., Habier, J., Herold, M., Narayanasamy, S., Kaysen, A., Hogan, A. H., Bindl, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07631-x · Cited by 292 · see citing works
Transmission modes of the mammalian gut microbiota
Moeller, A. H., Suzuki, T. A., Phifer‐Rixey, M., & Nachman, M. W. (2018) · Science · doi:10.1126/science.aat7164 · Cited by 285 · see citing works
Perinatal factors affect the gut microbiota up to four years after birth
Fouhy, F., Watkins, C., Hill, C. J., O’Shea, C.-A., Nagle, B., Dempsey, E. M., O’Toole, P. W., Ross, R. P., Ryan, C. A., & Stanton, C. (2019) · Nature Communications · doi:10.1038/s41467-019-09252-4 · Cited by 274 · see citing works
Metagenomic Analysis of Milk of Healthy and Mastitis-Suffering Women
Jiménez, E., de Andrés, J., Manrique, M., Pareja-Tobes, P., Tobes, R., Martínez-Blanch, J. F., Codoñer, F. M., Ramón, D., Fernández, L., & Rodríguez, J. M. (2015) · Journal of Human Lactation · doi:10.1177/0890334415585078 · Cited by 269 · see citing works
Lack of detection of a human placenta microbiome in samples from preterm and term deliveries
Leiby, J. S., McCormick, K., Sherrill-Mix, S. A., Clarke, E., Kessler, L. R., Taylor, L. J., Hofstaedter, C. E., Roche, A. M., Mattei, L. M., Bittinger, K. L., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0575-4 · Cited by 267 · see citing works
Schwartz, S., Friedberg, I., Ivanov, I. V., Davidson, L. A., Goldsby, J. S., Dahl, D. B., Herman, D., Wang, M., Donovan, S. M., & Chapkin, R. S. (2012) · Genome biology · doi:10.1186/gb-2012-13-4-r32 · Cited by 261 · see citing works
Lundgren, S., Madan, J. C., Emond, J. A., Morrison, H. G., Christensen, B. C., Karagas, M. R., & Hoen, A. G. (2018) · Microbiome · doi:10.1186/s40168-018-0490-8 · Cited by 261 · see citing works
Antibiotics in early life: dysbiosis and the damage done
Neuman, H., Forsythe, P., Uzan-Yulzari, A., Avni, O., & Koren, O. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy018 · Cited by 258 · see citing works
Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy
Nuriel‐Ohayon, M., Neuman, H., Oren, Z., Belogolovski, A., Barsheshet, Y., Bloch, N., Uzan-Yulzari, A., Lahav, R., Peretz, A., Frishman, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.075 · Cited by 255 · see citing works
Factors Affecting Gastrointestinal Microbiome Development in Neonates
Chong, C. Y. L., Bloomfield, F. H., & O'Sullivan, J. M. (2018) · Nutrients · doi:10.3390/nu10030274 · Cited by 250 · see citing works
A microbial perspective of human developmental biology
Charbonneau, M. R., Blanton, L. V., DiGiulio, D. B., Relman, D. A., Lebrilla, C. B., Mills, D. A., & Gordon, J. I. (2016) · Nature · doi:10.1038/nature18845 · Cited by 246 · see citing works
Nogacka, A. M., Salazar, N., Suárez, M., Milani, C., Arboleya, S., Sánchez, G. S., Fernández, N., Alaez, L., Hernández‐Barranco, A. M., Reyes‐Gavilán, C. G. D. L., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0313-3 · Cited by 236 · see citing works
Racial disparity in the frequency of recurrence of preterm birth
Kistka, Z. A.-F., Palomar, L., Lee, K. A., Boslaugh, S., Wangler, M. F., Cole, F. S., DeBaun, M. R., & Muglia, L. J. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.06.093 · Cited by 222 · see citing works
Gohir, W., Whelan, F. J., Surette, M. G., Moore, C., Schertzer, J. D., & Sloboda, D. M. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1086056 · Cited by 203 · see citing works
Baumann-Dudenhoeffer, A. M., D’Souza, A. W., Tarr, P. I., Warner, B. B., & Dantas, G. A. (2018) · Nature Medicine · doi:10.1038/s41591-018-0216-2 · Cited by 203 · see citing works
Alderete, T. L., Autran, C. A., Brekke, B., Knight, R. D., Bode, L., Goran, M. I., & Fields, D. A. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.115451 · Cited by 200 · see citing works
Increased richness and diversity of the vaginal microbiota and spontaneous preterm birth
Freitas, A. C., Bocking, A. D., Hill, J. E., & Money, D. (2018) · Microbiome · doi:10.1186/s40168-018-0502-8 · Cited by 199 · see citing works
Freitas, A. C., Chaban, B. L., Bocking, A. D., Rocco, M., Yang, S., Hill, J. E., Money, D., Hemmingsen, S. M., Reid, G., Dumonceaux, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07790-9 · Cited by 198 · see citing works
Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants
Stanislawski, M. A., Dabelea, D., Wagner, B. D., Sontag, M. K., Lozupone, C., & Eggesbø, M. Å. (2017) · Microbiome · doi:10.1186/s40168-017-0332-0 · Cited by 181 · see citing works
Early gut mycobiota and mother-offspring transfer
Schei, K., Avershina, E., Øien, T., Rudi, K., Follestad, T., Salamati, S., & Ødegård, R. A. (2017) · Microbiome · doi:10.1186/s40168-017-0319-x · Cited by 179 · see citing works
Goltsman, D. S. A., Sun, C. L., Proctor, D. M., DiGiulio, D. B., Robaczewska, A., Thomas, B. C., Shaw, G. M., Stevenson, D. K., Holmes, S., Banfield, J. F., et al. (2018) · Genome Research · doi:10.1101/gr.236000.118 · Cited by 148 · see citing works
Ojala, T., Kankainen, M., Castro, J., Cerca, N., Edelman, S., Westerlund‐Wikström, B., Paulin, L. G., Holm, L., & Auvinen, P. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1070 · Cited by 130 · see citing works
Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
McCann, A., Ryan, F. J., Stockdale, S. R., Dalmasso, M., Blake, T., Ryan, C. A., Stanton, C., Mills, S., Ross, P. R., & Hill, C. (2018) · PeerJ · doi:10.7717/peerj.4694 · Cited by 129 · see citing works
The Bacterial Microbiome and Virome Milestones of Infant Development
Lim, E. S., Wang, D., & Holtz, L. R. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.06.001 · Cited by 128 · see citing works
Individuality and convergence of the infant gut microbiota during the first year of life
de Muinck, E. J., & Trosvik, P. (2018) · Nature Communications · doi:10.1038/s41467-018-04641-7 · Cited by 126 · see citing works
The Human Microbiome before Birth
Blaser, M. J., & Domínguez-Bello, M. G. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.10.014 · Cited by 123 · see citing works
Influence of Feeding Type on Gut Microbiome Development in Hospitalized Preterm Infants
Cong, X. S., Judge, M. P., Xu, W., Diallo, A. F., Janton, S., Brownell, E., Maas, K. R., & Graf, J. (2017) · Nursing Research · doi:10.1097/nnr.0000000000000208 · Cited by 123 · see citing works
Unveiling bifidobacterial biogeography across the mammalian branch of the tree of life
Milani, C., Mangifesta, M., Mancabelli, L., Lugli, G. A., James, K., Duranti, S., Turroni, F., Ferrario, C., Ossiprandi, M. C., van Sinderen, D., et al. (2017) · The ISME Journal · doi:10.1038/ismej.2017.138 · Cited by 119 · see citing works
Cooperstock, M. S., & Zedd, A. J. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-341280-5.50010-0 · Cited by 117 · see citing works
Mazzola, G., Murphy, K., Ross, R. P., Gioia, D. D., Biavati, B., Corvaglia, L., Faldella, G., & Stanton, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157527 · Cited by 116 · see citing works
Dotterud, C. K., Avershina, E., Sekelja, M., Simpson, M. R., Rudi, K., Storrø, O., Johnsen, R., & Øien, T. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000781 · Cited by 112 · see citing works
Keski‐Nisula, L., Kyynäräinen, H., Kärkkäinen, U., Karhukorpi, J. M., Heinonen, S. T., & Pekkanen, J. (2013) · Acta Paediatrica · doi:10.1111/apa.12186 · Cited by 111 · see citing works
Advances in Infant Formula Science
Ahern, G. J., Hennessy, A. A., Ryan, C. A., Ross, R. P., & Stanton, C. (2019) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-081318-104308 · Cited by 99 · see citing works
Infant fungal communities: current knowledge and research opportunities
Ward, T., Knights, D., & Gale, C. A. (2017) · BMC Medicine · doi:10.1186/s12916-017-0802-z · Cited by 94 · see citing works
Biagi, E., Aceti, A., Quercia, S., Beghetti, I., Rampelli, S., Turroni, S., Soverini, M., Zambrini, A. V., Faldella, G., Candela, M., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02512 · Cited by 94 · see citing works
Milani, C., Casey, E., Lugli, G. A., Moore, R., Kaczorowska, J., Feehily, C., Mangifesta, M., Mancabelli, L., Duranti, S., Turroni, F., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0527-z · Cited by 73 · see citing works
Influence of Pregnancy History on the Vaginal Microbiome of Pregnant Women in their First Trimester
Nasioudis, D., Forney, L. J., Schneider, G., Gliniewicz, K., France, M., Boester, A., Sawai, M., Scholl, J. E., & Witkin, S. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-09857-z · Cited by 68 · see citing works
Does a prenatal bacterial microbiota exist?
Hornef, M. W., & Penders, J. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.141 · Cited by 65 · see citing works
Social networks, cooperative breeding, and the human milk microbiome
Meehan, C. L., Lackey, K. A., Hagen, E. H., Williams, J. E., Roulette, J. W., Helfrecht, C., McGuire, M. A., & McGuire, M. K. (2018) · American Journal of Human Biology · doi:10.1002/ajhb.23131 · Cited by 60 · see citing works
Colonization of Cutibacterium avidum during infant gut microbiota establishment
Martin, V. N. R., Schwab, C., Krych, Ł., Voney, E., Geirnaert, A., Braegger, C., & Lacroix, C. (2018) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiy215 · Cited by 54 · see citing works
Selective colonization ability of human fecal microbes in different mouse gut environments
Zhou, W. L., Chow, K.-H., Fleming, E. S., & Oh, J. (2018) · The ISME Journal · doi:10.1038/s41396-018-0312-9 · Cited by 52 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Self-citationGilliland, A., Chan, J. J., Wolfe, T. J. D., Yang, H., & Vallance, B. A. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.09.019 · Cited by 229 · see citing works
Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis
Ratsika, A., Codagnone, M. G., O’Mahony, S. M., Stanton, C., & Cryan, J. F. (2021) · Nutrients · doi:10.3390/nu13020423 · Cited by 184 · see citing works
Microbial transmission, colonisation and succession: from pregnancy to infancy
Xiao, L., & Zhao, F. (2023) · Gut · doi:10.1136/gutjnl-2022-328970 · Cited by 183 · see citing works
Kohl, K. D. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0251 · Cited by 168 · see citing works
Kim, E., Paik, D., Ramírez, R. N., Biggs, D. G., Park, Y., Kwon, H., Choi, G. B., & Huh, J. R. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.005 · Cited by 148 · see citing works
Clinical implications of preterm infant gut microbiome development
Healy, D., Ryan, C. A., Ross, R. P., Stanton, C., & Dempsey, E. M. (2021) · Nature Microbiology · doi:10.1038/s41564-021-01025-4 · Cited by 132 · see citing works
Captivity and Animal Microbiomes: Potential Roles of Microbiota for Influencing Animal Conservation
Dallas, J. W., & Warne, R. W. (2022) · Microbial Ecology · doi:10.1007/s00248-022-01991-0 · Cited by 134 · see citing works
Secretory IgA: Linking microbes, maternal health, and infant health through human milk
Donald, K., Petersen, C., Turvey, S. E., Finlay, B. B., & Azad, M. B. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.02.005 · Cited by 131 · see citing works
Mother–infant transmission of human microbiota
Browne, H. P., Shao, Y., & Lawley, T. D. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102173 · Cited by 112 · see citing works
Enduring behavioral effects induced by birth by caesarean section in the mouse
Morais, L. H., Golubeva, A. V., Moloney, G. M., Moya-Pérez, A., Ventura-Silva, A. P., Arboleya, S., Bastiaanssen, T. F. S., O’Sullivan, O., Rea, K., Borre, Y., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.07.044 · Cited by 104 · see citing works
Exploring the Potential of Human Milk and Formula Milk on Infants’ Gut and Health
Chong, H.-Y., Tan, L. T., Law, J. W., Hong, K., Ratnasingam, V., Mutalib, N. A., Lee, L., & Letchumanan, V. (2022) · Nutrients · doi:10.3390/nu14173554 · Cited by 103 · see citing works
Lou, Y. C., Olm, M. R., Diamond, S., Crits‐Christoph, A., Firek, B., Baker, R. W., Morowitz, M. J., & Banfield, J. F. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100393 · Cited by 88 · see citing works
Tarracchini, C., Milani, C., Longhi, G., Fontana, F., Mancabelli, L., Pintus, R., Lugli, G. A., Alessandri, G., Anzalone, R., Viappiani, A., et al. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.01176-21 · Cited by 85 · see citing works
Lin, C., Lin, Y., Zhang, H., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14071498 · Cited by 85 · see citing works
The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk
Usami, K., Niimi, K., Matsuo, A., Suyama, Y., Sakai, Y., Sato, S., Fujihashi, K., Kiyono, H., Uchino, S., Furukawa, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109655 · Cited by 82 · see citing works
Wang, S., Egan, M., Ryan, C. A., Boyaval, P., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa030 · Cited by 78 · see citing works
Liang, W., Waeckel-Énée, E., Andre-Vallee, C., Falcone, M., Sun, J. T., & Diana, J. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.12.272 · Cited by 76 · see citing works
The human gut microbiota during the initial stages of life: insights from bifidobacteria
Turroni, F., Milani, C., Ventura, M., & van Sinderen, D. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.07.012 · Cited by 69 · see citing works
Wicaksono, W. A., Cernava, T., Wassermann, B., Abdelfattah, A., Soto-Girón, M. J., Toledo, G. V., Virtanen, S. M., Knip, M., Hyöty, H., & Berg, G. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2258565 · Cited by 66 · see citing works
Mining chicken ileal microbiota for immunomodulatory microorganisms
Liu, Y., Feng, Y., Yang, X., Lv, Z., Li, P., Zhang, M., Wei, F., Jin, X., Hu, Y., Guo, Y., et al. (2023) · The ISME Journal · doi:10.1038/s41396-023-01387-z · Cited by 66 · see citing works
Early life gut microbiome and its impact on childhood health and chronic conditions
Núñez, H., Nieto, P. A., Mars, R. A. T., Ghavami, M., Hoy, C. S., & Sukhum, K. V. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2463567 · Cited by 74 · see citing works
Crosstalk between sIgA-Coated Bacteria in Infant Gut and Early-Life Health
Ding, M., Yang, B. K., Ross, R. P., Stanton, C., Zhao, J., Zhang, H., & Chen, W. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.012 · Cited by 61 · see citing works
A metagenomic catalog of the early-life human gut virome
Zeng, S., Almeida, A., Li, S., Ying, J., Wang, H., Qu, Y., Ross, R. P., Stanton, C., Zhou, Z., Niu, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45793-z · Cited by 58 · see citing works
Wiesmann, C. L., Wang, N. R., Zhang, Y., Liu, Z., & Haney, C. H. (2022) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuac048 · Cited by 53 · see citing works
Busi, S. B., de Nies, L., Habier, J., Wampach, L., Fritz, J. V., Heintz‐Buschart, A., May, P., Halder, R., de Beaufort, C. E., & Wilmes, P. (2021) · ISME Communications · doi:10.1038/s43705-021-00003-5 · Cited by 52 · see citing works
Wang, S., Zeng, S., Egan, M., Cherry, P., Strain, C., Morais, E. D. S., Boyaval, P., Ryan, C. A., Dempsey, E. M., Ross, R. P., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1911571 · Cited by 52 · see citing works
Transmission and dynamics of mother-infant gut viruses during pregnancy and early life
Garmaeva, S., Sinha, T., Gulyaeva, A. A., Kuzub, N., Spreckels, J. E., Andreu‐Sánchez, S., Gaćeša, R., Vila, A. V., Brushett, S., Kruk, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45257-4 · Cited by 48 · see citing works
The effects of microbiota on reproductive health: A review
Wang, N., Chen, L., Yi, K., Zhang, B., Li, C., & Zhou, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2117784 · Cited by 49 · see citing works
Qi, C., Zhou, J., Tu, H., Tu, R., Chang, H., Chen, J., Li, D., Sun, J., & Yu, R. (2021) · Food & Function · doi:10.1039/d1fo03131g · Cited by 47 · see citing works
Early-life exposures and the microbiome: implications for IBD prevention
Zhang, L., Agrawal, M., Ng, S. C., & Jess, T. (2023) · Gut · doi:10.1136/gutjnl-2023-330002 · Cited by 49 · see citing works
Infant gut DNA bacteriophage strain persistence during the first 3 years of life
Lou, Y. C., Chen, L., Borges, A. L., West-Roberts, J. A., Firek, B., Morowitz, M. J., & Banfield, J. F. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.11.015 · Cited by 45 · see citing works
Leyva, L. L., Brereton, N. J. B., & Koski, K. G. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.11.057 · Cited by 45 · see citing works
Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome
Fan, H., Tung, Y., Yang, Y. S. H., Hsu, J. B., Lee, C., Chang, T., Su, E. C., Hsieh, R., & Chen, Y. (2021) · Nutrients · doi:10.3390/nu13051559 · Cited by 43 · see citing works
Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis
Priyadarshini, M., Navarro, G., Reiman, D. J., Sharma, A., Xu, K., Lednovich, K., Manzella, C. R., Khan, M. W., Garcia, M. S., Allard, S. M., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.01.008 · Cited by 42 · see citing works
Bacteriophage-mediated modulation of microbiota for diseases treatment
Zhang, Y., Li, C., & Zhang, X. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113856 · Cited by 41 · see citing works
Lynch, S. V., & Vercelli, D. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202010-3779pp · Cited by 41 · see citing works
Early gut microbiota intervention in premature infants: Application perspectives
Xiang, Q., Yan, X., Shi, W., Li, H., & Zhou, K. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.11.004 · Cited by 43 · see citing works
Reconstitution and Transmission of Gut Microbiomes and Their Genes between Generations
Rosenberg, E., & Zilber-Rosenberg, I. (2021) · Microorganisms · doi:10.3390/microorganisms10010070 · Cited by 38 · see citing works
Ding, M., Li, B., Chen, H., Liang, D., Ross, R. P., Stanton, C., Zhao, J., Chen, W., & Yang, B. K. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2290344 · Cited by 36 · see citing works
Life at the borderlands: microbiomes of interfaces critical to One Health
Law, S. R., Mathes, F., Paten, A. M., Alexandre, P. A., Regmi, R., Reid, C. J., Safarchi, A., Shaktivesh, S., Wang, Y., Wilson, A., et al. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae008 · Cited by 38 · see citing works
Wang, M., Zhang, Y., Miller, D., Rehman, N., Cheng, X., Yeo, J., Joe, B., & Hill, J. W. (2020) · Endocrinology · doi:10.1210/endocr/bqz041 · Cited by 36 · see citing works
Calatayud, M., García‐Barrera, T., Leblic, B. C., Arias‐Borrego, A., & Collado, M. C. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115994 · Cited by 36 · see citing works
Nelson, B. N., & Friedman, J. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115951 · Cited by 36 · see citing works
Ecological change of the gut microbiota during pregnancy and progression to dyslipidemia
Xu, Y., Zhang, M., Zhang, Y., Wei, H., Guan, Q., Dong, C., Deng, S., Tun, H. M., & Xia, Y. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00383-7 · Cited by 37 · see citing works
Xue, C., Xie, Q., Zhang, C., Hu, Y., Song, X., Jia, Y., Shi, X., Chen, Y., Liu, Y., Zhao, L., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01318-8 · Cited by 34 · see citing works
Miao, S., Yin, J., Liu, S., Zhu, Q., Liao, C., & Jiang, G. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c02018 · Cited by 34 · see citing works
Song, B., Sun, P., Kong, L., Xiao, C., Pan, X., & Song, Z. (2024) · Journal of Animal Science · doi:10.1093/jas/skae286 · Cited by 32 · see citing works
Sow Contact Is a Major Driver in the Development of the Nasal Microbiota of Piglets
Obregón-Gutierrez, P., Aragón, V., & Correa‐Fiz, F. (2021) · Pathogens · doi:10.3390/pathogens10060697 · Cited by 32 · see citing works
Maternal effects on early-life gut microbiota maturation in a wild nonhuman primate
Baniel, A., Petrullo, L. A., Mercer, A., Reitsema, L. J., Sams, S. N., Beehner, J. C., Bergman, T. J., Snyder‐Mackler, N., & Lu, A. (2022) · Current Biology · doi:10.1016/j.cub.2022.08.037 · Cited by 42 · see citing works
Spatiotemporal patterns of the pregnancy microbiome and links to reproductive disorders
Xiao, L., Tian, Z., Zuo, Z., Sun, N., & Zhao, F. (2024) · 中国科学通报:英文版 · doi:10.1016/j.scib.2024.02.001 · Cited by 31 · see citing works
Zhang, D., Xie, D., Qu, Y., Mu, D., & Wang, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2451071 · Cited by 34 · see citing works
Morais, J., Marques, C., Teixeira, D., Durão, C., Faria, A., Brito, S., Cardoso, M., Macedo, I., Pereira, E., Tomé, T., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1785804 · Cited by 31 · see citing works
McGrath-Blaser, S. E., Steffen, M. M., Grafe, T. U., Torres‐Sánchez, M., McLeod, D. S., & Muletz‐Wolz, C. R. (2021) · Animal Microbiome · doi:10.1186/s42523-021-00147-8 · Cited by 32 · see citing works
Deciphering the role of female reproductive tract microbiome in reproductive health: a review
Gao, H., Liu, Q., Wang, X., Li, T., Li, H., Li, G., Tan, L., & Chen, Y. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1351540 · Cited by 34 · see citing works
The gut core microbial species Bifidobacterium longum: Colonization, mechanisms, and health benefits
Xiao, Y., Huang, L., Zhao, J., Chen, W., & Lu, W. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127966 · Cited by 31 · see citing works
Ma, B., Sundararajan, S., Nadimpalli, G., France, M., McComb, E. J., Rutt, L., Lemme‐Dumit, J. M., Janofsky, E., Roskes, L. S., Gajer, P., et al. (2022) · mBio · doi:10.1128/mbio.01299-22 · Cited by 31 · see citing works
Zhong, Z., Tang, H., Shen, T., Ma, X., Zhao, F., Kwok, L., Sun, Z., Bilige, M., & Zhang, H. (2022) · Microbiome · doi:10.1186/s40168-022-01398-6 · Cited by 31 · see citing works
Clinical implications of maternal multikingdom transmissions and early-life microbiota
Zeng, S., Zhou, M., Mu, D., & Wang, S. (2025) · The Lancet Microbe · doi:10.1016/j.lanmic.2024.101042 · Cited by 30 · see citing works
Yan, X., Si, H., Zhu, Y., Li, S., Yu, H., Liu, H., Du, R., Pope, P. B., Qiu, Q., & Li, Z. (2022) · Microbiome · doi:10.1186/s40168-022-01396-8 · Cited by 29 · see citing works
Health Impact and Therapeutic Manipulation of the Gut Microbiome
Daliri, E. B., Ofosu, F. K., Chelliah, R., Lee, B. H., & Oh, D. (2020) · Microarrays · doi:10.3390/ht9030017 · Cited by 28 · see citing works
Ventura, E. F., Esteban-Torres, M., Gueimonde, M., van Sinderen, D., Koren, O., Hall, L. J., Segata, N., Valles‐Colomer, M., & Collado, M. C. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00720-y · Cited by 27 · see citing works
Wang, K., Kong, X., Azad, M. A. K., Zhu, Q., Xiong, L., Zheng, Y., Hu, Z., Yin, Y., & He, Q. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6618874 · Cited by 25 · see citing works
Effect of Sow Intestinal Flora on the Formation of Endometritis
Zhang, L., Wang, L., Dai, Y., Tao, T., Wang, J., Wu, Y., Zeng, X., & Zhang, J. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.663956 · Cited by 25 · see citing works
Wu, Y., Zhang, X., Pi, Y., Han, D., Feng, C., Zhao, J., Chen, L., Che, D., Bao, H., Xie, Z., et al. (2021) · Food & Function · doi:10.1039/d1fo00084e · Cited by 25 · see citing works
The impact of maternal exposure to antibiotics on the development of child gut microbiome
Miyoshi, J., & Hisamatsu, T. (2021) · Immunological Medicine · doi:10.1080/25785826.2021.1963189 · Cited by 24 · see citing works
Wei, Q., Jiang, Z., Shi, H., Zou, J., Lu, W., Xiao, X., & Zhang, Y. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105787 · Cited by 23 · see citing works
Gao, M., Chen, S., Fan, H., Li, P., Liu, A., Li, D., Li, X., Hu, Y., Han, G., Guo, Y., et al. (2025) · iMeta · doi:10.1002/imt2.70044 · Cited by 22 · see citing works
Azevedo, M. J., Garcia, A., Costa, C. F. F. A., Ferreira, A. F., Falcão‐Pires, I., Brandt, B. W., Ramalho, C. M. A., Zaura, E., & Sampaio‐Maia, B. (2023) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2023.06.002 · Cited by 23 · see citing works
Phylogenetic signal in gut microbial community rather than in rodent metabolic traits
Zhang, X., Khakisahneh, S., Liu, W. Y., Zhang, X., Zhai, W., Cheng, J., Speakman, J. R., & Wang, D. (2023) · National Science Review · doi:10.1093/nsr/nwad209 · Cited by 22 · see citing works
Infant gut microbiome reprogramming following introduction of solid foods (weaning)
Ding, M., Ross, R. P., Dempsey, E. M., Li, B., & Stanton, C. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2571428 · Cited by 22 · see citing works
Qi, Y., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2022) · Nutrients · doi:10.3390/nu14020390 · Cited by 21 · see citing works
Kefir microbiota and metabolites stimulate intestinal mucosal immunity and its early development
Chen, W., Wang, J., Du, L., Chen, J., Zheng, Q., Li, P., Du, B., Fang, X., & Liao, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2115975 · Cited by 21 · see citing works
Gao, S., & Wang, J. (2023) · Protein & Cell · doi:10.1093/procel/pwad029 · Cited by 22 · see citing works
Rahkola, E.-N., Rautava, S., Hiltunen, H., Ross, C., Lahti, L., & Isolauri, E. (2023) · Pediatric Research · doi:10.1038/s41390-023-02560-y · Cited by 20 · see citing works
Ding, M., Zheng, Y., Liu, F., Tian, F., Ross, R. P., Stanton, C., Yu, R., Zhao, J., Zhang, H., Yang, B. K., et al. (2022) · Beneficial Microbes · doi:10.3920/bm2021.0119 · Cited by 18 · see citing works
Kouete, M. T., Bletz, M. C., LaBumbard, B. C., Woodhams, D. C., & Blackburn, D. C. (2023) · Animal Microbiome · doi:10.1186/s42523-023-00243-x · Cited by 18 · see citing works
Liu, Y., Ma, J., Zhu, B., Liu, F., Qin, S., Lv, N., Feng, Y., Wang, S., & Yang, H. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1163269 · Cited by 18 · see citing works
Wu, Y., Zhang, X., Tao, S., Pi, Y., Han, D., Ye, H., Feng, C., Zhao, J., Chen, L., & Wang, J. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104170 · Cited by 18 · see citing works
Meredith, H. R., Kularatna, S., Nagaro, K. J., Nagahawatte, A., Bodinayake, C. K., Kurukulasooriya, R. M., Wijesingha, N., Harden, L., Piyasiri, D. L. B., Hammouda, A., et al. (2021) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-021-00938-3 · Cited by 17 · see citing works
Cohen, C. C., Perng, W., Sauder, K. A., Shapiro, A. L. B., Starling, A. P., Friedman, C., Felix, J. F., Küpers, L. K., Moore, B. F., Hébert, J. R., et al. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.01.039 · Cited by 17 · see citing works
Ding, M., Yang, B. K., Khine, W. W. T., Lee, Y. K., Rahayu, E. S., Ross, R. P., Stanton, C., Zhao, J., Zhang, H., & Chen, W. (2021) · Microorganisms · doi:10.3390/microorganisms9091995 · Cited by 17 · see citing works
Zeng, S., Ying, J., Li, S., Qu, Y., Mu, D., & Wang, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.905380 · Cited by 17 · see citing works
Cheng, R., Zhang, Y., Yang, Y., Ren, L., Li, J., Wang, Y., Shen, X. P., & He, F. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1045109 · Cited by 16 · see citing works
Skillington, O., Mills, S., Gupta, A., Mayer, E. A., Gill, C. I. R., Rio, D. D., O’Riordan, K. J., Cryan, J. F., Ross, R. P., & Stanton, C. (2021) · Nutrition and Healthy Aging · doi:10.3233/nha-210129 · Cited by 16 · see citing works
Nguyen, G., Hayes, L., Ngongalah, L., Bigirumurame, T., Gaudet, L., Odeniyi, A., Flynn, A., Crowe, L., Skidmore, B., Simon, A., et al. (2022) · Obesity Reviews · doi:10.1111/obr.13491 · Cited by 14 · see citing works
Liu, J., Chen, Y., Laurent, I., Yang, P. C., Xiao, X., & Li, X. (2024) · Nutrition and Diabetes · doi:10.1038/s41387-024-00346-7 · Cited by 15 · see citing works
Intestinal dysbiosis during pregnancy and microbiota-associated impairments in offspring
Abu, Y. F., & Roy, S. (2025) · Frontiers in Microbiomes · doi:10.3389/frmbi.2025.1548650 · Cited by 18 · see citing works
Microbiome and Brain Development: A Tale of Two Systems
Cryan, J. F. (2025) · Annals of Nutrition and Metabolism · doi:10.1159/000544950 · Cited by 15 · see citing works
Microbiome function and neurodevelopment in Black infants: vitamin B 12 emerges as a key factor
Oliphant, K., Ayala, W. C., Ilyumzhinova, R., Mbayiwa, K., Sroka, A. W., Xie, B., Andrews, B., Keenan, K. E., & Claud, E. C. (2024) · Gut Microbes · doi:10.1080/19490976.2023.2298697 · Cited by 14 · see citing works
Liu, Y., Ma, J., Li, X., Zhao, H., Ai, Q., Zhang, L., Tong, Y., Meng, L., & Yang, H. (2025) · Microbiome · doi:10.1186/s40168-024-02024-3 · Cited by 15 · see citing works
The social microbiome: The missing mechanism mediating the sociality-fitness nexus?
Baniel, A., & Charpentier, M. J. E. (2024) · iScience · doi:10.1016/j.isci.2024.109806 · Cited by 14 · see citing works
Oguri, N., Kobayashi, C., Ozawa, Y., Kimura, T., Nishinarita, Y., Wada, H., Nemoto, N., Narita, M., Tanigaki, S., Hanawa, T., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63466-3 · Cited by 12 · see citing works
Gut microbiota transfer evidence from mother to newborn
Caprara, G. L., Lovison, O. V. A., Martins, A. F., Bernardi, J. R., & Goldani, M. Z. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-05341-1 · Cited by 12 · see citing works
Maternal pre- and postnatal stress and maternal and infant gut microbiota features
Eckermann, H. A., Lustermans, H., Pärnänen, K. M. M., Lahti, L., & de Weerth, C. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107273 · Cited by 12 · see citing works
Gut microbiota as a regulator of vaccine efficacy: implications for personalized vaccination
Lu, Q., Feng, Y., Wang, H., Zhu, K., Teng, L., Yue, M., & Li, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2563709 · Cited by 12 · see citing works
Metagenomics Approaches to Investigate the Neonatal Gut Microbiome
Boudar, Z., Sehli, S., Janahi, S. E., Idrissi, N. A., Hamdi, S., Dini, N., Brim, H., Amzazi, S., Nejjari, C., Lloyd-Puryear, M. A., et al. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.886627 · Cited by 15 · see citing works
Shen, W., Qiu, W., Liu, Y., Liao, W., Ma, Y., He, Y., Wang, Z., & Zhou, H. (2021) · Translational Pediatrics · doi:10.21037/tp-21-367 · Cited by 11 · see citing works
Gut mycobiome in cardiometabolic disease progression: current evidence and future directions
Wei, X., Guo, Z., Wang, J., Gao, D., Xu, Q., & Hua, S. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1659654 · Cited by 10 · see citing works
Fernandes, M., Azevedo, M. J., Campos, C., Ferreira, A. F., Azevedo, Á. F., Falcão‐Pires, I., Zaura, E., Ramalho, C. M. A., Campos, J., & Sampaio‐Maia, B. (2023) · Pathogens · doi:10.3390/pathogens12010080 · Cited by 10 · see citing works
- Authors
- Wang, S., Ryan, C. A., Boyaval, P., Dempsey, E. M., Ross, R. P., & Stanton, C.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- DuPont (France) (FR)
- Corresponding author
- Stanton, Catherine
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 28
- Issue
- 1
- Pages
- 28-45
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2972272530
- Cited by
- 243
- References
- 121
- Citations by year
- 2026: 24 · 2025: 53 · 2024: 33 · 2023: 34 · 2022: 45 · 2021: 41 · 2020: 13
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- APC
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- human microbiome, pregnancy, births, infancy, microbiota-targeted interventions
- MeSH terms
- Gastrointestinal Microbiome, Mycobiome, Adult, Diet, Female, Humans, Infant, Milk, Human, Mothers, Pregnancy, Vagina, Infectious Disease Transmission, Vertical, Probiotics, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review