The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Curvotaxis directs cell migration through cell-scale curvature landscapes
Open accessAbstract
Cells have evolved multiple mechanisms to apprehend and adapt finely to their environment. Here we report a new cellular ability, which we term “curvotaxis” that enables the cells to respond to cell-scale curvature variations, a ubiquitous trait of cellular biotopes. We develop ultra-smooth sinusoidal surfaces presenting modulations of curvature in all directions, and monitor cell behavior on these topographic landscapes. We show that adherent cells avoid convex regions during their migration and position themselves in concave valleys. Live imaging combined with functional analysis shows that curvotaxis relies on a dynamic interplay between the nucleus and the cytoskeleton—the nucleus acting as a mechanical sensor that leads the migrating cell toward concave curvatures. Further analyses show that substratum curvature affects focal adhesions organization and dynamics, nuclear shape, and gene expression. Altogether, this work identifies curvotaxis as a new cellular guiding mechanism and promotes cell-scale curvature as an essential physical cue.
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Cites
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Cited by
Substrate curvature as a cue to guide spatiotemporal cell and tissue organization
Callens, S. J. P., Uyttendaele, R. J. C., Fratila-Apachitei, L. E., & Zadpoor, A. A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119739 · Cited by 323
Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling
Dalton, C. J., & Lemmon, C. A. (2021) · Cells · doi:10.3390/cells10092443 · Cited by 319
Metadata
- Authors
- Pieuchot, L., Marteau, J., Guignandon, A., Dos Santos, T., Brigaud, I., Chauvy, P.-F., Cloatre, T., Ponche, A., Petithory, T., Rougerie, P., Vassaux, M., Milan, J.-L., Tusamda Wakhloo, N., Spangenberg, A., Bigerelle, M., & Anselme, K.
- Venue
- Nature Communications
- Published
- 2018-09-28
- Volume
- 9
- Issue
- 1
- Pages
- 3995-3995
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2892459790
- Cited by
- 304
- References
- 62
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pieuchot, L., Marteau, J., Guignandon, A., Dos Santos, T., Brigaud, I., Chauvy, P.-F., Cloatre, T., Ponche, A., Petithory, T., Rougerie, P., Vassaux, M., Milan, J.-L., Tusamda Wakhloo, N., Spangenberg, A., Bigerelle, M., & Anselme, K. (2018). Curvotaxis directs cell migration through cell-scale curvature landscapes. Nature Communications. https://doi.org/10.1038/s41467-018-06494-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
