The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
A chemically fuelled self-replicator
Open accessAbstract
The continuous consumption of chemical energy powers biological systems so that they can operate functional supramolecular structures. A goal of modern science is to understand how simple chemical mixtures may transition from non-living components to truly emergent systems and the production of new lifelike materials and machines. In this work a replicator can be maintained out-of-equilibrium by the continuous consumption of chemical energy. The system is driven by the autocatalytic formation of a metastable surfactant whose breakdown products are converted back into building blocks by a chemical fuel. The consumption of fuel allows the high-energy replicators to persist at a steady state, much like a simple metabolic cycle. Thermodynamically-driven reactions effect a unidirectional substrate flux as the system tries to regain equilibrium. The metastable replicator persists at a higher concentration than achieved even transiently in a closed system, and its concentration is responsive to the rate of fuel supply.
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Cites
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A Self‐Replicating Hexadeoxynucleotide
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Autocatalytic self-replicating micelles as models for prebiotic structures
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Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions
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Cited by
Active coacervate droplets as a model for membraneless organelles and protocells
Donau, C., Späth, F., Sosson, M., Kriebisch, B. A. K., Schnitter, F., Tena-Solsona, M., Kang, H.-S., Salibi, E., Sattler, M., Mutschler, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18815-9 · Cited by 309
Chemical Fueling Enables Molecular Complexification of Self‐Replicators**
Yang, S., Schaeffer, G., Mattia, E., Markovitch, O., Liu, K., Hussain, A. S., Ottelé, J., Sood, A., & Otto, S. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202016196 · Cited by 86
Liu, B., Wu, J., Geerts, M., Markovitch, O., Pappas, C. G., Liu, K., & Otto, S. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202117605 · Cited by 60
Dissipative self-assembly, competition and inhibition in a self-reproducing protocell model
Post, E. A. J., & Fletcher, S. P. (2020) · Chemical Science · doi:10.1039/d0sc02768e · Cited by 57
Self-citation
Metadata
- Authors
- Morrow, S. M., Colomer, I., & Fletcher, S. P.
- Venue
- Nature Communications
- Published
- 2019-03-01
- Volume
- 10
- Issue
- 1
- Pages
- 1011-1011
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2919993307
- Cited by
- 166
- References
- 11
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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