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Cited by 487

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

Open access
Kranzler, Henry R., Zhou, Hang, Kember, Rachel L., Vickers Smith, Rachel, Justice, Amy C., Damrauer, Scott, Tsao, Philip S., Klarin, Derek, Baras, Aris, Reid, Jeffrey, Overton, John, Rader, Daniel J., Cheng, Zhongshan, Tate, Janet P., Becker, William C., Concato, John, Xu, Ke, Polimanti, Renato, Zhao, Hongyu, Gelernter, Joel·2019·Nature Communications
DOI 10.1038/s41467-019-09480-8
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Abstract

Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores and AUD diagnoses in a multi-ancestry Million Veteran Program sample (N = 274,424). We identify 18 genome-wide significant loci: 5 associated with both traits, 8 associated with AUDIT-C only, and 5 associated with AUD diagnosis only. Polygenic Risk Scores (PRS) for both traits are associated with alcohol-related disorders in two independent samples. Although a significant genetic correlation reflects the overlap between the traits, genetic correlations for 188 non-alcohol-related traits differ significantly for the two traits, as do the phenotypes associated with the traits’ PRS. Cell type group partitioning heritability enrichment analyses also differentiate the two traits. We conclude that, although heavy drinking is a key risk factor for AUD, it is not a sufficient cause of the disorder.

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Show all 31 references

Research works printed but not linked: 34

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Metadata

Authors
Kranzler, H. R., Zhou, H., Kember, R. L., Vickers Smith, R., Justice, A. C., Damrauer, S., Tsao, P. S., Klarin, D., Baras, A., Reid, J., Overton, J., Rader, D. J., Cheng, Z., Tate, J. P., Becker, W. C., Concato, J., Xu, K., Polimanti, R., Zhao, H., & Gelernter, J.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2019-04-02
Volume
10
Issue
1
Pages
1499-1499
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-019-09480-8
OpenAlex
W2928966425
Cited by
487
References
31
FWCI
33.86
Type
journal article
Language
en
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Open access
gold
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CoChat. (2026). Citation check: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. https://app.cochat.ai/papers/10.1038/s41467-019-09480-8
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Kranzler, H. R., Zhou, H., Kember, R. L., Vickers Smith, R., Justice, A. C., Damrauer, S., Tsao, P. S., Klarin, D., Baras, A., Reid, J., Overton, J., Rader, D. J., Cheng, Z., Tate, J. P., Becker, W. C., Concato, J., Xu, K., Polimanti, R., Zhao, H., & Gelernter, J. (2019). Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications. https://doi.org/10.1038/s41467-019-09480-8

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