The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
The lncRNA Neat1 promotes activation of inflammasomes in macrophages
Open accessAbstract
The inflammasome has an essential function in innate immune, responding to a wide variety of stimuli. Here we show that the lncRNA Neat1 promotes the activation of several inflammasomes.Neat1 associates with the NLRP3, NLRC4, and AIM2 inflammasomes in mouse macrophages to enhance their assembly and subsequent pro-caspase-1 processing.Neat1 also stabilizes the mature caspase-1 to promote interleukin-1β production and pyroptosis. Upon stimulation with inflammasome-activating signals,Neat1, which normally resides in the paraspeckles, disassociates from these nuclear bodies and translocates to the cytoplasm to modulate inflammasome activation using above mechanism.Neat1 is also up-regulated under hypoxic conditions in a HIF-2α-dependent manner, mediating the effect of hypoxia on inflammasomes. Moreover, in the mouse models of peritonitis and pneumonia,Neat1 deficiency significantly reduces inflammatory responses. These results reveal a previously unrecognized role of lncRNAs in innate immunity, and suggest that Neat1 is a common mediator for inflammasome stimuli.
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Cited by
Vanderbeke, L., Van Mol, P., Van Herck, Y., De Smet, F., Humblet-Baron, S., Martinod, K., Antoranz, A., Arijs, I., Boeckx, B., Bosisio, F. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24360-w · Cited by 247
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine
Wen, S., Wei, Y., Zen, C., Xiong, W., Niu, Y., & Zhao, Y. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01293-4 · Cited by 259
Noncoding RNAs in age-related cardiovascular diseases
Jusic, A., Thomas, P. B., Wettinger, S. B., Dogan, S., Farrugia, R., Gaetano, C., Tuna, B. G., Pinet, F., Robinson, E. L., Tual-Chalot, S., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101610 · Cited by 70
lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta
Wu, Y., Li, P., Liu, L., Goodwin, A. J., Halushka, P. V., Hirose, T., Nakagawa, S., Zhou, J., Liu, M., & Fan, H. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.03.011 · Cited by 28
Metadata
- Authors
- Zhang, P., Cao, L., Zhou, R., Yang, X., & Wu, M.
- Venue
- Nature Communications
- Published
- 2019-04-02
- Volume
- 10
- Issue
- 1
- Pages
- 1495-1495
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2926902798
- Cited by
- 499
- References
- 71
- FWCI
- 19.05
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- creativecommons.org/licenses/by/4.0 (tdm)
- creativecommons.org/licenses/by/4.0 (vor)
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