The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
Open accessAbstract
Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack of knowledge about natural drug gels limits there current application. Here, we report on rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions. This hydrogel shows excellent stability, sustained release and reversible stimuli-responses. The hydrogel consists of a three-dimensional nanofiber network that prevents premature degradation. Moreover, it easily enters cells and binds to toll-like receptor 4. This enables rhein hydrogels to significantly dephosphorylate IκBα, inhibiting the nuclear translocation of p65 at the NFκB signalling pathway in lipopolysaccharide-induced BV2 microglia. Subsequently, rhein hydrogels alleviate neuroinflammation with a long-lasting effect and little cytotoxicity compared to the equivalent free-drug in vitro. This study highlights a direct self-assembly hydrogel from natural small molecule as a promising neuroinflammatory therapy.
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Cites
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Cited by
Stimuli‐Responsive Biomolecule‐Based Hydrogels and Their Applications
Vázquez‐González, M., & Willner, I. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201907670 · Cited by 444
Metadata
- Authors
- Zheng, J., Fan, R., Wu, H., Yao, H., Yan, Y., Liu, J., Ran, L., Sun, Z., Yi, L., Dang, L., Gan, P., Zheng, P., Yang, T., Zhang, Y., Tang, T., & Wang, Y.
- Venue
- Nature Communications
- Published
- 2019-04-08
- Volume
- 10
- Issue
- 1
- Pages
- 1604-1604
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2939058834
- Cited by
- 414
- References
- 52
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zheng, J., Fan, R., Wu, H., Yao, H., Yan, Y., Liu, J., Ran, L., Sun, Z., Yi, L., Dang, L., Gan, P., Zheng, P., Yang, T., Zhang, Y., Tang, T., & Wang, Y. (2019). Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation. Nature Communications. https://doi.org/10.1038/s41467-019-09601-3
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