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A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging

Open access
Jiang, Yuyan, Huang, Jiaguo, Zhen, Xu, Zeng, Ziling, Li, Jingchao, Xie, Chen, Miao, Qingqing, Chen, Jie, Chen, Peng, Pu, Kanyi·2019·Nature Communications

Abstract

Afterglow imaging with long-lasting luminescence after cessation of light excitation provides opportunities for ultrasensitive molecular imaging; however, the lack of biologically compatible afterglow agents has impeded exploitation in clinical settings. This study presents a generic approach to transforming ordinary optical agents (including fluorescent polymers, dyes, and inorganic semiconductors) into afterglow luminescent nanoparticles (ALNPs). This approach integrates a cascade photoreaction into a single-particle entity, enabling ALNPs to chemically store photoenergy and spontaneously decay it in an energy-relay process. Not only can the afterglow profiles of ALNPs be finetuned to afford emission from visible to near-infrared (NIR) region, but also their intensities can be predicted by a mathematical model. The representative NIR ALNPs permit rapid detection of tumors in living mice with a signal-to-background ratio that is more than three orders of magnitude higher than that of NIR fluorescence. The biodegradability of the ALNPs further heightens their potential for ultrasensitive in vivo imaging.

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Metadata

Authors
Jiang, Y., Huang, J., Zhen, X., Zeng, Z., Li, J., Xie, C., Miao, Q., Chen, J., Chen, P., & Pu, K.
Venue
Nature Communications
Published
2019-05-02
Volume
10
Issue
1
Pages
2064-2064
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2943080811
Cited by
311
References
4
FWCI
14.07
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. https://app.cochat.ai/papers/10.1038/s41467-019-10119-x
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Jiang, Y., Huang, J., Zhen, X., Zeng, Z., Li, J., Xie, C., Miao, Q., Chen, J., Chen, P., & Pu, K. (2019). A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. Nature Communications. https://doi.org/10.1038/s41467-019-10119-x

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