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A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging
Open accessAbstract
Afterglow imaging with long-lasting luminescence after cessation of light excitation provides opportunities for ultrasensitive molecular imaging; however, the lack of biologically compatible afterglow agents has impeded exploitation in clinical settings. This study presents a generic approach to transforming ordinary optical agents (including fluorescent polymers, dyes, and inorganic semiconductors) into afterglow luminescent nanoparticles (ALNPs). This approach integrates a cascade photoreaction into a single-particle entity, enabling ALNPs to chemically store photoenergy and spontaneously decay it in an energy-relay process. Not only can the afterglow profiles of ALNPs be finetuned to afford emission from visible to near-infrared (NIR) region, but also their intensities can be predicted by a mathematical model. The representative NIR ALNPs permit rapid detection of tumors in living mice with a signal-to-background ratio that is more than three orders of magnitude higher than that of NIR fluorescence. The biodegradability of the ALNPs further heightens their potential for ultrasensitive in vivo imaging.
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Second window for in vivo imaging
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Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., & van der Vliet, A. (1998) · Nature · doi:10.1038/34923 · Cited by 1,496
Supervised Machine Learning for Population Genetics: A New Paradigm
Schrider, D. R., & Kern, A. D. (2018) · Trends in Genetics · doi:10.1016/j.tig.2017.12.005 · Cited by 453
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Li, J., & Pu, K. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00569 · Cited by 412
Self-citationNIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274
Metadata
- Authors
- Jiang, Y., Huang, J., Zhen, X., Zeng, Z., Li, J., Xie, C., Miao, Q., Chen, J., Chen, P., & Pu, K.
- Venue
- Nature Communications
- Published
- 2019-05-02
- Volume
- 10
- Issue
- 1
- Pages
- 2064-2064
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2943080811
- Cited by
- 311
- References
- 4
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jiang, Y., Huang, J., Zhen, X., Zeng, Z., Li, J., Xie, C., Miao, Q., Chen, J., Chen, P., & Pu, K. (2019). A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. Nature Communications. https://doi.org/10.1038/s41467-019-10119-x
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