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Cited by 321

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science

Open access
Sichtig, Heike, Minogue, Timothy, Yan, Yi, Stefan, Christopher, Hall, Adrienne, Tallon, Luke, Sadzewicz, Lisa, Nadendla, Suvarna, Klimke, William, Hatcher, Eneida, Shumway, Martin, Aldea, Dayanara Lebron, Allen, Jonathan, Koehler, Jeffrey, Slezak, Tom, Lovell, Stephen, Schoepp, Randal, Scherf, Uwe·2019·Nature Communications

Abstract

FDA proactively invests in tools to support innovation of emerging technologies, such as infectious disease next generation sequencing (ID-NGS). Here, we introduce FDA-ARGOS quality-controlled reference genomes as a public database for diagnostic purposes and demonstrate its utility on the example of two use cases. We provide quality control metrics for the FDA-ARGOS genomic database resource and outline the need for genome quality gap filling in the public domain. In the first use case, we show more accurate microbial identification of Enterococcus avium from metagenomic samples with FDA-ARGOS reference genomes compared to non-curated GenBank genomes. In the second use case, we demonstrate the utility of FDA-ARGOS reference genomes for Ebola virus target sequence comparison as part of a composite validation strategy for ID-NGS diagnostic tests. The use of FDA-ARGOS as an in silico target sequence comparator tool combined with representative clinical testing could reduce the burden for completing ID-NGS clinical trials.

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Metadata

Authors
Sichtig, H., Minogue, T., Yan, Y., Stefan, C., Hall, A., Tallon, L., Sadzewicz, L., Nadendla, S., Klimke, W., Hatcher, E., Shumway, M., Aldea, D. L., Allen, J., Koehler, J., Slezak, T., Lovell, S., Schoepp, R., & Scherf, U.
Venue
Nature Communications
Published
2019-07-25
Volume
10
Issue
1
Pages
3313-3313
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2963839877
Cited by
321
References
6
FWCI
17.40
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science. https://app.cochat.ai/papers/10.1038/s41467-019-11306-6
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Sichtig, H., Minogue, T., Yan, Y., Stefan, C., Hall, A., Tallon, L., Sadzewicz, L., Nadendla, S., Klimke, W., Hatcher, E., Shumway, M., Aldea, D. L., Allen, J., Koehler, J., Slezak, T., Lovell, S., Schoepp, R., & Scherf, U. (2019). FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science. Nature Communications. https://doi.org/10.1038/s41467-019-11306-6

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.