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A meta-analysis of genome-wide association studies identifies multiple longevity genes
Open accessAbstract
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78 , associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.
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“Several studies of large populations of individuals from European ancestry have raised the possibility that APOE is a longevity gene, with the APOEε2 variant associated with longer survival and the APOEε4 with shorter survival in a dose-dependent manner90–94.”
From Multifaceted roles of APOE in Alzheimer disease (2024) · cites this paper as [92]
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“In contrast, APOE2 carriers trended towards better survival in patients with low risk of melanoma-associated death (Extended Data Fig. 9c–g), consistent with the known association of APOE2 with enhanced lifespan in the general population24.”
From Common germline variants of the human APOE gene modulate melanoma progression and survival (2020) · cites this paper as [24]
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“This is aligned with previous findings and reinforces the hypothesis that disease risk reduces lifespan via shared biological pathways45–47.”
From Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans (2026) · cites this paper as [46]
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“Genes that regulate lifespan in animal models6–9 and human studies10–14 as well as multiple experimental paradigms, such as caloric restriction, heterochronic parabiosis and partial epigenetic reprogramming, have demonstrated that it is possible to manipulate ageing biology to ‘rejuvenate’ physiological functioning in complex model organisms15–28.”
From Measuring biological age using omics data (2022) · cites this paper as [12]
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“Various studies show that carriers of the ɛ4 allele live shorter lives and have higher risks of death (Deelen et al., 2019; Drenos & Kirkwood, 2010; Kulminski et al., 2014; Nygaard et al., 2014; Raichlen & Alexander, 2014; Sebastiani et al., 2019; Wolters et al., 2019; Yashin et al., 2018).”
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“53,54 The same gene serves as a pathogenic culprit for Koolen De Vries syndrome characterized by intellectual disability accompanied by characteristic facial features and hypotonia, 55 a longevity gene 56 and a contributor to Alzheimer’s disease phenotypes.”
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“267,268 ApoE is the major carrying molecule for lipids, and its consistent association with longevity highlights the major impact of atherosclerotic disease on lifespan.”
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“53 Interestingly, we identified rs429358 as one of the most significantly associated variants in our study, which is a replication of the results of Fritsche et al. 7 The variant rs7412 reaches genome-wide significance (Supplementary Table S5), but this finding seems to be affected and loses its…”
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“The detailed methods have been reported in previous studies [21, 22].”
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“, beyond the age corresponding to the 90th or 99th survival percentile) (19).”
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“Also, the exceptional longevity (EL), like the Long-Life Family Study project, has been generating multi-omic data 6,7 to identify protective biomarkers and pathways for long and healthy life.”
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“In the largest GWAS to date [14], minor allele carriers of the variant rs2802292, together with carriers of rs10457180, which is also in FOXO3 and in strong linkage disequilibrium (r2 = 0.”
BackgroundA phylogenetic method linking nucleotide substitution rates to rates of continuous trait evolution
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“Moreover, large-scale multi-omics data, like genetics, epigenetics, transcriptomics, proteomics, and metabolomics (Deelen et al. 2019, Raghavachari et al. 2022) are being generated by ongoing NIA-supported exceptional longevity (EL) studies, including the Long-Life Family Study (LLFS), the…”
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“Third, only a small number of longevity-related germ line variants have been identified in the longevity cohorts using genome-wide scanning method (Deelen et al., 2019 ), although emerging evidence suggests that CENs may be at greater threat from genome-wide somatic mutations due to their much…”
BackgroundGuo, Y., Ma, G., Wang, Y., Lin, T., Hu, Y., & Zang, T. (2024) · Aging Cell · doi:10.1111/acel.14271 · Cited by 12
“The multivariate GWAS summary-level dataset comprises four aging phenotypes (Timmers et al., 2020 ), which are healthspan (Zenin et al., 2019), parental lifespan (Timmers et al., 2019), and extreme longevity (Deelen et al., 2019) ( Table 1 ).”
The 90 plus: longevity and COVID-19 survival
Zatz, M., Silva, M. V. R., de Castro, M. V., & Naslavsky, M. S. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01461-6 · Cited by 10
“THE IMPORTANCE OF ELDERLY POPULATION-BASED COHORTS Previous genome-wide associations studies (GWAS) and functional studies [54] in long-lived individuals (aged > 90 years old) as compared to younger control individuals (aged < 65 years old) have identified several genetic variants which are more common in the older gr…”
BackgroundHigh polygenic risk score for exceptional longevity is associated with a healthy metabolic profile
Revelas, M., Thalamuthu, A., Zettergren, A., Oldmeadow, C. J., Najar, J., Seidu, N. M., Armstrong, N. J., Riveros, C., Kwok, J. B., Schofield, P. R., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00643-y · Cited by 11
“Deelen et al. found EL was genetically correlated with coronary artery disease (CAD), type 2 diabetes and paternal age at death [38].”
InfluentialChen, H., Zhou, X., Hu, J., Li, S., Wang, Z., Zhu, T., Cheng, H., & Zhang, G. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01983-0 · Cited by 10
“The validation GWAS data follow a binary design that comprises 36,745 Euro-peans, including 11,262 individuals of European ancestry who survived past the 90th survival percentile and 25,483 control individuals [21].”
BackgroundMethodEscribà-Montagut, X., Marcon, Y., Anguita‐Ruiz, A., Avraam, D., Urquiza, J., Morgan, A. S., Wilson, B., Burton, P. R., & González, J. R. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012626 · Cited by 10
Li, M., Kwok, M.-K., & Schooling, C. M. (2021) · Nutrients · doi:10.3390/nu13072215 · Cited by 10
Are Alzheimer's and coronary artery diseases genetically related to longevity?
Bellou, E., & Escott‐Price, V. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1102347 · Cited by 10
Wang, S., Li, H., Nishijo, M., Nishino, Y., Kato, N., Kasamaki, Y., Ueda, T., & Kanda, T. (2020) · Journal of International Medical Research · doi:10.1177/0300060520964016 · Cited by 9
“Accordingly, human longevity can be inherited, and ApoE is related to a lower odds ratio with respect to survival to the 90th and 99th percentiles of age(7,16) ApoE-e4 carrier status has important implications for associations between the brain and cardiovascular health in aging adults.(17) A lack of ApoE and lipid ov…”
BackgroundShultz, S., Britnell, J., & Harvey, N. (2021) · Ecology and Evolution · doi:10.1002/ece3.8331 · Cited by 9
“The role of environmental traits and functional indicators of health outcomes (i.e., reproductive failure, elevated mortality) can be evaluated using a model selection approach (Deelen et al., 2019).”
Backgroundde Rojas, I., Hernández, I., Montrreal, L., Quintela, I., Calero, M., Royo, J. L., Vilas, R. H., González-Pérez, A., Macías, E. F., Macı́as, J., et al. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11121318 · Cited by 9
“Beyond its involvement in dementia causality, the locus is also involved in a number of cardiovascular phenotypes [21] and human longevity [22,23] of special interest for dementia studies like GR@ACE/DEGESCO.”
BackgroundYu, Z., Zhang, F., Xu, C., & Wang, Y.-G. (2022) · BioMed Research International · doi:10.1155/2022/4012603 · Cited by 10
“Therefore, the in fl u-ence of heterogeneity between cases and controls can be mitigated [32].”
InfluentialAjnakina, O., Shamsutdinova, D., Wimberley, T., Dalsgaard, S., & Steptoe, A. (2022) · BMC Medicine · doi:10.1186/s12916-022-02279-3 · Cited by 7
“Nonetheless, mortality has been shown to have shared polygenic contributions with several other traits and conditions beyond ADHD, including educational attainment [34], coronary artery disease [35] and type 2 diabetes [36].”
BackgroundLiu, C., Zhu, T., Zhang, J., Wang, J., Gao, F., Ou, Q., Jin, C., Xu, J., Zhang, J., Tian, H., et al. (2021) · IUBMB Life · doi:10.1002/iub.2544 · Cited by 9
Escribe, C., Lu, T., Keller‐Baruch, J., Forgetta, V., Xiao, B., Richards, J. B., Bhatnagar, S., Oualkacha, K., & Greenwood, C. M. T. (2021) · Genetic Epidemiology · doi:10.1002/gepi.22430 · Cited by 9
Genetics of remnant cholesterol
Wulff, A. B., & Nordestgaard, B. G. (2025) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000991 · Cited by 8
Ma, Y., Yao, Y., Zhou, Y., Dai, W., Li, J., Gui, Y., Sun, H., Zhu, Z., Jiang, D., Cheng Ann, C. H. E. N., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-01027-5 · Cited by 8
“…( n = 300,477) 87 , parental lifespan ( n = 570,798) 88 , frailty ( n = 175,226) 89 , epigenetic age acceleration (EAA; n = 34,710) 90 , extreme longevity (90th percentile, n = 36,345; and 99th percentile, n = 28,967) 91 and the common factor multivariate longevity (mvAge; n = 1,958,774) 92 .”
Healthy dietary patterns, longevity genes, and life expectancy: A prospective cohort study
Lv, Y., Song, J., Ding, D., Luo, M., He, F. J., Yuan, C., MacGregor, G. A., Liu, L., & Chen, L. (2026) · Science Advances · doi:10.1126/sciadv.ads7559 · Cited by 9
Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging
Tan, Y. J., Conley, T. E., Yao, F., Garcia-Marques, F. J., Akinyemi, D. E., Dinh, V. V., Wang, Q., Bermudez, A., Kim, J., Belk, J. A., et al. (2026) · Science · doi:10.1126/science.aea3075 · Cited by 10
Qiu, S., Hu, Y., & Liu, G. (2023) · npj Aging · doi:10.1038/s41514-023-00126-0 · Cited by 9
“Cases were participants who lived to an age above the 90th (11,262 cases) or 99th percentile (3,484 cases) based on cohort life tables 41 .”
InfluentialHeterogeneous effects of genetic risk for Alzheimer’s disease on the phenome
Wu, H. M., Goate, A., & O’Reilly, P. F. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01518-0 · Cited by 8
“To account for the longevity effect— a possible confounder in our results of AD PRS—we repeated the analyses adjusting for longevity PRS [44] as a covariate.”
MethodNutrient-Response Pathways in Healthspan and Lifespan Regulation
Dabrowska, A. F., Kumar, J., & Rallis, C. (2022) · Cells · doi:10.3390/cells11091568 · Cited by 9
“Consistent with previous reports, the APOE2 variant was linked to longevity while APOE4 with lower odds of surviving to the 90th and 99th percentile age [109].”
BackgroundResultBerg, V., Lawson, D. W., & Rotkirch, A. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2478 · Cited by 8
A Brief Introduction to Darwinian Medicine
Lucock, M. D. (2022) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2022.00001 · Cited by 8
Jin, X., Xiong, S., Yuan, C., Gong, E., Zhang, X., Yao, Y., Leng, Y., Niu, Z., Zeng, Y., & Yan, L. L. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.697389 · Cited by 8
“Interestingly, nearly all such studies in different population have identified APOE gene as one of the genetic factors associated with mortality or longevity (9).”
BackgroundSelf-citationSchwenke, J. M., Thorball, C. W., Schoepf, I. C., Ryom, L., Hasse, B. K., Lamy, O., Calmy, A., Wandeler, G., Marzolini, C., Kahlert, C. R., et al. (2023) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiad179 · Cited by 7
“Because of the prevalent concern that aging in PLWH may be accelerated and/or accentuated, we also assessed a PRS based on 4 SNPs that have been reliably associated with successful aging and longevity in the general population [24, 25], as we did for coronary event prediction in PLWH [18].”
Xu, L., Wang, J., Li, X., Li, Y., Chen, C., Xu, Z., Yuan, X., Lu, Z., Zhou, J., Zhang, M., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04176-x · Cited by 9
“Gene-wide association studies (GWASs) have made it possible to identify multiple single nucleotide polymorphisms (SNPs) significantly associated with longevity [17, 18].”
Don, J., Schork, A. J., Glusman, G., Rappaport, N., Cummings, S., Duggan, D. J., Raju, A., Hellberg, K.-L. G., Gunn, S., Monti, S., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01107-1 · Cited by 8
“Interest-ingly, many of these studies suggest that long-lived individuals exhibit differences in disease PRS profiles as compared short-lived individuals, raising questions about the relationships between PLS, PRS, longevity, and disease [29, 40–42].”
BackgroundMethodInfluentialSelf-citationIlboudo, Y., Yoshiji, S., Lu, T., Butler‐Laporte, G., Zhou, S., & Richards, J. B. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-221223 · Cited by 9
Bradley, J. L., Pottier, C. P., da Fonseca, E. L., Kurup, J. T., Western, D., Wang, C., Neupane, A., Ray, N. R., Jean‐Francois, M. N., Ali, M., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70377 · Cited by 9
Dungan, J. R., Qin, X., Hurdle, M., Haynes, C. S., Hauser, E. R., & Kraus, W. E. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.661497 · Cited by 7
“…for the use of medications such as aspirin and other antiplatelet agents, statins, and beta-blockers, which are well-established independent predictors of survival and mortality among CAD patients (Antithrombotic Trialists’ Collaboration, 2002; Dézsi and Szentes, 2017; Rodriguez et al., 2019).”
BackgroundRaghavachari, N., Wilmot, B., & Dutta, C. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac065 · Cited by 7
Ni, X., Liu, L., Yao, Y., Zhang, C., Su, H., Lv, Y., Li, R., Sun, L., Zhou, Q., Zhu, X., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1096662 · Cited by 7
“Calcium supplementation is a common practice in the USA, and there is rising clinical interest with respect to the association between these supplements and CVD.”
BackgroundMethodInfluentialHow‐Kit, A., Sahbatou, M., Hardy, L. M., Tessier, N. P., Schiavon, V., Buanec, H. L., Sébaoun, J.-M., Blanché, H., Zagury, J., & Deleuze, J. (2023) · GeroScience · doi:10.1007/s11357-023-01037-4 · Cited by 6
“3, with longevity ( p = 1.74 × 10 −8 ) and survival beyond 90 years of age ( p = 0.003) [41], and of rs7676745 near GPR78 with longevity ( p = 4.3 × 10 −8 ) [43].”
InfluentialSelf-citationEffects of aging on gene expression networks in the Drosophila genetic reference panel
Tan, S., Carbone, M. A., Zhou, S., Morozova, T. V., Arya, G. H., Zhang, F., Anholt, R. R. H., Huang, W., & Mackay, T. F. C. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115999 · Cited by 6
“Genome-wide transcriptional 6–9 and association 10–12 studies have identified many genetic factors associated with aging and/or variation in lifespan in humans.”
Dong, C., Thalamuthu, A., Jiang, J., Mather, K. A., Brodaty, H., Sachdev, P. S., & Wen, W. X. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab323 · Cited by 6
Srinivasan, Y., Briano, J., Czaja, S. J., Lachs, M. S., Rosen, A. E., Stewart, M. G., & Rameau, A. (2024) · The Laryngoscope · doi:10.1002/lary.31446 · Cited by 6
Jonas, D. A., Sándor, S., Tátrai, K., Egyed, B., & Kubinyi, E. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00315 · Cited by 5
Improved selection of participants in genetic longevity studies: family scores revisited
Rodríguez-Girondo, M., van den Berg, N., Hof, M. H. P., Beekman, M., & Slagboom, P. E. (2021) · BMC Medical Research Methodology · doi:10.1186/s12874-020-01193-7 · Cited by 6
Self-citationGenetic basis of cardiovascular aging is at the core of human longevity
Marian, A. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.06 · Cited by 6
“, the E4 allele is associated with lower odds of surviving to old age, whereas the E2 allele frequency is the opposite[62,81,82].”
BackgroundKashtanova, D. A., Мамчур, А. А., Dzhumaniyazova, I. H., Ivanov, M. V., Erema, V. V., Zelenova, Е., Yakovchik, A., Gusakova, M., Rumyantseva, A. M., Terekhov, M. V., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1273825 · Cited by 6
Current Trends and Approaches to the Search for Genetic Determinants of Aging and Longevity
Станиславовна, К. С., Volobaev, V. P., Plotnikova, M. Y., Kupriyanova, D. A., Kuznetsova, I. L., Tyazhelova, T. V., & Rogaev, E. I. (2022) · Russian Journal of Genetics · doi:10.1134/s1022795422120067 · Cited by 7
Metadata
- Authors
- Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppälä, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N., Becker, E. J., Beekman, M., Blanché, H., Christensen, K., Christiansen, L., Collerton, J. C., Cubaynes, S., Cummings, S. R., Davies, K., Debrabant, B., Deleuze, J.-F., Duncan, R., Faul, J. D., Franceschi, C., Galan, P., Gudnason, V., Harris, T. B., Huisman, M., Hurme, M. A., Jagger, C., Jansen, I., Jylhä, M., Kähönen, M., Karasik, D., Kardia, S. L. R., Kingston, A., Kirkwood, T. B. L., Launer, L. J., Lehtimäki, T., Lieb, W., Lyytikäinen, L.-P., Martin-Ruiz, C., Min, J., Nebel, A., Newman, A. B., Nie, C., Nohr, E. A., Orwoll, E. S., Perls, T. T., Province, M. A., Psaty, B. M., Raitakari, O. T., Reinders, M. J. T., Robine, J.-M., Rotter, J. I., Sebastiani, P., Smith, J., Sørensen, T. I. A., Taylor, K. D., Uitterlinden, A. G., van der Flier, W., van der Lee, S. J., van Duijn, C. M., van Heemst, D., Vaupel, J. W., Weir, D., Ye, K., Zeng, Y., Zheng, W., Holstege, H., Kiel, D. P., Lunetta, K. L., Slagboom, P. E., & Murabito, J. M.
- Affiliations
- Leiden University (NL)
- California Pacific Medical Center (US)
- Johns Hopkins University (US)
- University of Southern Denmark (DK)
- BGI Group (China) (CN)
- Washington University in St. Louis (US)
- University of Washington (US)
- Albert Einstein College of Medicine (US)
- University of Michigan (US)
- Boston University (US)
- Tampere University (FI)
- Centre for Life (GB)
- Christian-Albrechts-Universität zu Kiel (DE)
- Erasmus MC (NL)
- Sema4 (United States) (US)
- Fondation Jean Dausset-CEPH (FR)
- Royal Victoria Infirmary (GB)
- Inserm (FR)
- Newcastle University (GB)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- University of Iceland (IS)
- National Institutes of Health (US)
- Amsterdam Public Health (NL)
- Amsterdam Neuroscience (NL)
- Bar-Ilan University (IL)
- Zhejiang University (CN)
- University of Pittsburgh (US)
- Oregon Health & Science University (US)
- Kaiser Permanente Washington Health Research Institute (US)
- University of Turku (FI)
- Delft University of Technology (NL)
- Centre National de la Recherche Scientifique (FR)
- The Lundquist Institute (US)
- University of Copenhagen (DK)
- University of California, Los Angeles (US)
- Max Planck Institute for Demographic Research (DE)
- Duke University (US)
- Amsterdam UMC Location University of Amsterdam (NL)
- Broad Institute (US)
- Corresponding author
- Deelen, Joris
- Evans, Daniel S.
- Slagboom, P. Eline
- Murabito, Joanne M.
- ORCID
- Deelen, Joris
- Evans, Daniel S.
- Arking, Dan E.
- Tesi, Niccolò
- Nygaard, Marianne
- Liu, Xiaomin
- Wojczynski, Mary K.
- van der Spek, Ashley
- Atzmon, Gil
- Ware, Erin B.
- Sarnowski, Chloé
- Smith, Albert V.
- Seppälä, Ilkka
- Cordell, Heather J.
- Dose, Janina
- Amin, Najaf
- Arnold, Alice M.
- Ayers, Kristin L.
- Barzilai, Nir
- Beekman, Marian
- Blanché, Hélène
- Christensen, Kaare
- Christiansen, Lene
- Cubaynes, Sarah
- Cummings, Steven R.
- Davies, Karen
- Debrabant, Birgit
- Deleuze, Jean-François
- Duncan, Rachel
- Faul, Jessica D.
- Franceschi, Claudio
- Galan, Pilar
- Gudnason, Vilmundur
- Harris, Tamara B.
- Huisman, Martijn
- Hurme, Mikko A.
- Jagger, Carol
- Jansen, Iris
- Jylhä, Marja
- Kähönen, Mika
- Karasik, David
- Kingston, Andrew
- Kirkwood, Thomas B. L.
- Launer, Lenore J.
- Lehtimäki, Terho
- Lieb, Wolfgang
- Lyytikäinen, Leo-Pekka
- Martin-Ruiz, Carmen
- Min, Junxia
- Newman, Anne B.
- Nie, Chao
- Nohr, Ellen A.
- Orwoll, Eric S.
- Perls, Thomas T.
- Province, Michael A.
- Psaty, Bruce M.
- Raitakari, Olli T.
- Reinders, Marcel J. T.
- Robine, Jean-Marie
- Rotter, Jerome I.
- Smith, Jennifer
- Sørensen, Thorkild I. A.
- Taylor, Kent D.
- Uitterlinden, André G.
- van der Lee, Sven J.
- Vaupel, James W.
- Weir, David
- Ye, Kenny
- Zheng, Wanlin
- Holstege, Henne
- Kiel, Douglas P.
- Lunetta, Kathryn L.
- Slagboom, P. Eline
- Murabito, Joanne M.
- Venue
- Nature Communications
- Published
- 2019-08-14
- Volume
- 10
- Issue
- 1
- Pages
- 3669-3669
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6694136
- OpenAlex
- W2967338832
- Cited by
- 370
- References
- 61
- Citations by year
- 2026: 38 · 2025: 64 · 2024: 56 · 2023: 60 · 2022: 51 · 2021: 53 · 2020: 44 · 2019: 3
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-04-23)
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, cc-by)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- VU Research Portal (publishedVersion, other-oa)
- HAL (submittedVersion, cc-by)
- Opin vísindi (Opin vísindi) (submittedVersion, cc-by-nc-sa)
- UTUPub (University of Turku) (submittedVersion)
- UTUPub (University of Turku) (submittedVersion, cc-by)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Opin vísindi (Opin vísindi) (submittedVersion, cc-by)
- Opin vísindi (Opin vísindi) (submittedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion, cc-by)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
- Tampere University Institutional Repository (Tampere University) (submittedVersion, cc-by)
- Research Repository (Delft University of Technology) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- Alexander von Humboldt-Stiftung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- human longevity, longevity genes, apolipoprotein E, APOE ε4, APOE ε2, tissue-specific gene expression, genetic correlation, heritability of longevity, genetic overlap
- MeSH terms
- Endoplasmic Reticulum Chaperone BiP, Heat-Shock Proteins, Humans, Longevity, Apolipoprotein E4, Apolipoprotein E2, Genome-Wide Association Study
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