A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control

Sun, Zhichen; Ren, Zhenhua; Yang, Kaiting; Liu, Zhida; Cao, Shuaishuai; Deng, Sisi; Xu, Lily; Liang, Yong; Guo, Jingya; Bian, Yingjie; Xu, Hairong; Shi, Jiyun; Wang, Fan; Fu, Yang-Xin; Peng, Hua

doi:10.1038/s41467-019-11782-w

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control

While IL-2 can potently activate both NK and T cells, its short in vivo half-life, severe toxicity, and propensity to amplify Treg cells are major barriers that prevent IL-2 from being widely used for cancer therapy. In this study, we construct a recombinant IL-2 immunocytokine comprising a tumor…