The structural basis for RNA selectivity by the IMP family of RNA-binding proteins

Biswas, Jeetayu; Patel, Vivek L.; Bhaskar, Varun; Chao, Jeffrey A.; Singer, Robert H.; Eliscovich, Carolina

doi:10.1038/s41467-019-12193-7

The structural basis for RNA selectivity by the IMP family of RNA-binding proteins

The IGF2 mRNA-binding proteins (ZBP1/IMP1, IMP2, IMP3) are highly conserved post-transcriptional regulators of RNA stability, localization and translation. They play important roles in cell migration, neural development, metabolism and cancer cell survival. The knockout phenotypes of individual I…