The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Thermo-responsive triple-function nanotransporter for efficient chemo-photothermal therapy of multidrug-resistant bacterial infection
Open accessAbstract
New strategies with high antimicrobial efficacy against multidrug-resistant bacteria are urgently desired. Herein, we describe a smart triple-functional nanostructure, namely TRIDENT (Thermo-Responsive-Inspired Drug-Delivery Nano-Transporter), for reliable bacterial eradication. The robust antibacterial effectiveness is attributed to the integrated fluorescence monitoring and synergistic chemo-photothermal killing. We notice that temperature rises generated by near-infrared irradiation did not only melt the nanotransporter via a phase change mechanism, but also irreversibly damaged bacterial membranes to facilitate imipenem permeation, thus interfering with cell wall biosynthesis and eventually leading to rapid bacterial death. Both in vitro and in vivo evidence demonstrate that even low doses of imipenem-encapsulated TRIDENT could eradicate clinical methicillin-resistant Staphylococcus aureus, whereas imipenem alone had limited effect. Due to rapid recovery of infected sites and good biosafety we envision a universal antimicrobial platform to fight against multidrug-resistant or extremely drug-resistant bacteria.
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Methicillin-resistant Staphylococcus aureus
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Self-citationFatty acids as phase change materials: A review
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Cited by
Zhao, X., Liang, Y., Huang, Y., He, J., Han, Y., & Guo, B. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910748 · Cited by 814
Self-citationXi, D., Xiao, M., Cao, J., Zhao, L., Xu, N., Long, S., Fan, J., Shao, K., Sun, W., Yan, X., et al. (2020) · Advanced Materials · doi:10.1002/adma.201907855 · Cited by 658
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Self-citationSynergistic antibacterial strategy based on photodynamic therapy: Progress and perspectives
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Self-citationMultifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels
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Metadata
- Authors
- Qing, G., Zhao, X., Gong, N., Chen, J., Li, X., Gan, Y., Wang, Y., Zhang, Z., Zhang, Y., Guo, W., Luo, Y., & Liang, X.-J.
- Venue
- Nature Communications
- Published
- 2019-09-24
- Volume
- 10
- Issue
- 1
- Pages
- 4336-4336
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2977110700
- Cited by
- 328
- References
- 47
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- gold
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- Qing, G., Zhao, X., Gong, N., Chen, J., Li, X., Gan, Y., Wang, Y., Zhang, Z., Zhang, Y., Guo, W., Luo, Y., & Liang, X.-J. (2019). Thermo-responsive triple-function nanotransporter for efficient chemo-photothermal therapy of multidrug-resistant bacterial infection. Nature Communications. https://doi.org/10.1038/s41467-019-12313-3
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