The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
Open accessAbstract
Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of bacterial resistance is a major concern. Here we systematically study the evolution of resistance to 14 chemically diverse AMPs and 12 antibiotics in Escherichia coli . Our work indicates that evolution of resistance against certain AMPs, such as tachyplesin II and cecropin P1, is limited. Resistance level provided by point mutations and gene amplification is very low and antibiotic-resistant bacteria display no cross-resistance to these AMPs. Moreover, genomic fragments derived from a wide range of soil bacteria confer no detectable resistance against these AMPs when introduced into native host bacteria on plasmids. We have found that simple physicochemical features dictate bacterial propensity to evolve resistance against AMPs. Our work could serve as a promising source for the development of new AMP-based therapeutics less prone to resistance, a feature necessary to avoid any possible interference with our innate immune system.
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Cites
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Wiegand, I., Hilpert, K., & Hancock, R. E. W. (2008) · Nature Protocols · doi:10.1038/nprot.2007.521 · Cited by 6,156
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
The shared antibiotic resistome of soil bacteria and human pathogens
Forsberg, K. J., Reyes, A., Wang, B., Selleck, E. M., Sommer, M. O. A., & Dantas, G. (2012) · Science · doi:10.1126/science.1220761 · Cited by 1,650
Functional characterization of the antibiotic resistance reservoir in the human microflora
Sommer, M. O. A., Dantas, G., & Church, G. M. (2009) · Science · doi:10.1126/science.1176950 · Cited by 878
CAMP R3 : a database on sequences, structures and signatures of antimicrobial peptides: Table 1.
Waghu, F. H., Barai, R. S., Gurung, P., & Idicula-Thomas, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1051 · Cited by 715
Cited by
Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields
Huan, Y., Kong, Q., Mou, H., & Yi, H. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.582779 · Cited by 1,595
The value of antimicrobial peptides in the age of resistance
Magana, M., Pushpanathan, M., Santos, A. L., Leanse, L., Fernandez, M., Ioannidis, A., Giulianotti, M. A., Apidianakis, Y., Bradfute, S., Ferguson, A. L., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30327-3 · Cited by 1,150
Antimicrobial peptides: Application informed by evolution
Lazzaro, B. P., Zasloff, M., & Rolff, J. (2020) · Science · doi:10.1126/science.aau5480 · Cited by 1,069
Gan, B. H., Gaynord, J., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00729c · Cited by 511
Antimicrobial peptides as therapeutic agents: opportunities and challenges
Mahlapuu, M., Björn, C., & Ekblom, J. (2020) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2020.1796576 · Cited by 484
Metadata
- Authors
- Spohn, R., Daruka, L., Lázár, V., Martins, A., Vidovics, F., Grézal, G., Méhi, O., Kintses, B., Számel, M., Jangir, P. K., Csörgő, B., Györkei, Á., Bódi, Z., Faragó, A., Bodai, L., Földesi, I., Kata, D., Maróti, G., Pap, B., Wirth, R., Papp, B., & Pál, C.
- Venue
- Nature Communications
- Published
- 2019-10-04
- Volume
- 10
- Issue
- 1
- Pages
- 4538-4538
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2979238556
- Cited by
- 358
- References
- 8
- FWCI
- 25.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Spohn, R., Daruka, L., Lázár, V., Martins, A., Vidovics, F., Grézal, G., Méhi, O., Kintses, B., Számel, M., Jangir, P. K., Csörgő, B., Györkei, Á., Bódi, Z., Faragó, A., Bodai, L., Földesi, I., Kata, D., Maróti, G., Pap, B., . . . Pál, C. (2019). Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance. Nature Communications. https://doi.org/10.1038/s41467-019-12364-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
