The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Antimicrobial peptides as therapeutic agents: opportunities and challenges
Open accessAbstract
The rapid development of microbial resistance to conventional antibiotics has accelerated efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial resistance. Intense nonclinical and clinical research is today ongoing to evaluate antimicrobial peptides (AMPs) as potential next-generation antibiotics. Currently, multiple AMPs are assessed in late-stage clinical trials, not only as novel anti-infective drugs, but also as innovative product candidates for immunomodulation, promotion of wound healing, and prevention of post-operative scars. The efforts to translate AMP-based research findings into pharmaceutical product candidates are expected to accelerate in coming years due to technological advancements in multiple areas, including an improved understanding of the mechanism-of-action of AMPs, smart formulation strategies, and advanced chemical synthesis protocols. At the same time, it is recognized that cytotoxicity, low metabolic stability due to sensitivity to proteolytic degradation, and limited oral bioavailability are some of the key weaknesses of AMPs. Furthermore, the pricing and reimbursement environment for new antimicrobial products remains as a major barrier to the commercialization of AMPs.
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Cites
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
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Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
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Antimicrobial Peptides: An Emerging Category of Therapeutic Agents
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Self-citation
Cited by
Antimicrobial peptides for combating drug-resistant bacterial infections
Xuan, J., Feng, W., Wang, J., Wang, R., Zhang, B., Bo, L., Chen, Z.-S., Yang, H., & Sun, L. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100954 · Cited by 665
Antimicrobial Peptides: An Update on Classifications and Databases
Bin Hafeez, A., Jiang, X., Bergen, P. J., & Zhu, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111691 · Cited by 341
Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications
Nikfarjam, N., Ghomi, M., Agarwal, T., Hassanpour, M., Sharifi, E., Khorsandi, D., Ali Khan, M., Rossi, F., Rossetti, A., Nazarzadeh Zare, E., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202104148 · Cited by 293
Wei, S., Xu, P., Yao, Z., Cui, X., Lei, X., Li, L., Dong, Y., Zhu, W., Guo, R., & Cheng, B. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.01.046 · Cited by 265
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Metadata
- Authors
- Mahlapuu, M., Björn, C., & Ekblom, J.
- Venue
- Critical Reviews in Biotechnology
- Publisher
- Informa UK Limited
- Published
- 2020-08-12
- Volume
- 40
- Issue
- 7
- Pages
- 978-992
- ISSN
- 0738-8551 (ISSN-L)
- 1549-7801
- OpenAlex
- W3048752454
- Cited by
- 484
- References
- 101
- FWCI
- 30.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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