The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Tailoring the component of protein corona via simple chemistry
Open accessAbstract
Control over the protein corona of nanomaterials allows them to function better. Here, by taking graphene/gold as examples, we comprehensively assessed the association of surface properties with the protein corona. As revealed by in vitro measurements and computations, the interaction between graphene/gold and HSA/IgE was inversely correlated with the hydroxyl group availability, whereas the interaction between that and ApoE was comparatively less relevant. Molecular simulations revealed that the number and the distribution of surface hydroxyl groups could regulate the manner in which nanomaterials interact with proteins. Moreover, we validated that ApoE pre-adsorption before injection enhances the blood circulation of nanomaterials relative to their pristine and IgE-coated counterparts. This benefit can be attributed to the invulnerability of the complementary system provided by ApoE, whose encasement does not increase cytotoxicity. Overall, this study offers a robust yet simple way to create protein corona enriched in dysopsonins to realize better delivery efficacy.
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Cites
Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
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Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
Chen, F., Wang, G., Griffin, J. I., Brenneman, B., Banda, N. K., Holers, V. M., Backos, D. S., Wu, L., Moghimi, S. M., & Simberg, D. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2016.269 · Cited by 599
Cloaking nanoparticles with protein corona shield for targeted drug delivery.
Oh, J. Y., Kim, H. S., Palanikumar, L., Go, E. M., Jana, B., Park, S. A., Kim, H. Y., Kim, K., Seo, J. K., Kwak, S. K., et al. (2018) · Nature communications · doi:10.1038/s41467-018-06979-4 · Cited by 409
The “Sweet” Side of the Protein Corona: Effects of Glycosylation on Nanoparticle–Cell Interactions
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Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.
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Cited by
Xu, M., Qi, Y., Liu, G., Song, Y., Jiang, X., & Du, B. (2023) · ACS Nano · doi:10.1021/acsnano.3c05853 · Cited by 632
Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine
Ren, J., Andrikopoulos, N., Velonia, K., Tang, H., Cai, R., Ding, F., Ke, P. C., & Chen, C. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c02277 · Cited by 284
Microglia-targeting nanotherapeutics for neurodegenerative diseases
Zhao, N., Francis, N. L., Calvelli, H. R., & Moghe, P. V. (2020) · APL Bioengineering · doi:10.1063/5.0013178 · Cited by 104
Metadata
- Authors
- Lu, X., Xu, P., Ding, H.-M., Yu, Y.-S., Huo, D., & Ma, Y.-Q.
- Venue
- Nature Communications
- Published
- 2019-10-04
- Volume
- 10
- Issue
- 1
- Pages
- 4520-4520
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2977326962
- Cited by
- 246
- References
- 7
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- gold
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