The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
Open accessAbstract
Circular RNAs (circRNAs) have been implicated in cancer progression through largely unknown mechanisms. Herein, we identify an N6-methyladenosine (m 6 A) modified circRNA, circNSUN2, frequently upregulated in tumor tissues and serum samples from colorectal carcinoma (CRC) patients with liver metastasis (LM) and predicts poorer patient survival. The upregulated expression of circNSUN2 promotes LM in PDX metastasis models in vivo and accelerates cancer cells invasion in vitro. Importantly, N6-methyladenosine modification of circNSUN2 increases export to the cytoplasm. By forming a circNSUN2/IGF2BP2/HMGA2 RNA-protein ternary complex in the cytoplasm, circNSUN2 enhances the stability of HMGA2 mRNA to promote CRC metastasis progression. Clinically, the upregulated expressions of circNSUN2 and HMGA2 are more prevalent in LM tissues than in primary CRC tissues. These findings elucidate that N6-methyladenosine modification of circNSUN2 modulates cytoplasmic export and stabilizes HMGA2 to promote CRC LM, and suggest that circNSUN2 could represent a critical prognostic marker and/or therapeutic target for the disease.
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1 retracted
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family
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Circular RNAs are a large class of animal RNAs with regulatory potency
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N6-methyladenosine-dependent regulation of messenger RNA stability
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Circular RNAs are abundant, conserved, and associated with ALU repeats
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Cancer Metastasis: Building a Framework
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N6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
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Cited by
LNCcation: lncRNA localization and function
Bridges, M. C., Daulagala, A. C., & Kourtidis, A. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202009045 · Cited by 1,556
The emerging roles of circRNAs in cancer and oncology
Kristensen, L. S., Jakobsen, T., Hager, H., & Kjems, J. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00585-y · Cited by 1,256
Integrated lncRNA function upon genomic and epigenomic regulation
Herman, A. B., Tsitsipatis, D., & Gorospe, M. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.05.027 · Cited by 747
Li, B., Zhu, L., Lu, C., Wang, C., Wang, H., Jin, H., Ma, X., Cheng, Z., Yu, C., Wang, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20527-z · Cited by 697
Self-citationColorectal liver metastasis: molecular mechanism and interventional therapy
Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00922-2 · Cited by 298
Metadata
- Authors
- Chen, R.-X., Chen, X., Xia, L.-P., Zhang, J.-X., Pan, Z.-Z., Ma, X.-D., Han, K., Chen, J.-W., Judde, J.-G., Deas, O., Wang, F., Ma, N.-F., Guan, X., Yun, J.-P., Wang, F.-W., Xu, R.-H., & Xie, D.
- Venue
- Nature Communications
- Published
- 2019-10-16
- Volume
- 10
- Issue
- 1
- Pages
- 4695-4695
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2981014677
- Cited by
- 734
- References
- 54
- FWCI
- 27.50
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chen, R.-X., Chen, X., Xia, L.-P., Zhang, J.-X., Pan, Z.-Z., Ma, X.-D., Han, K., Chen, J.-W., Judde, J.-G., Deas, O., Wang, F., Ma, N.-F., Guan, X., Yun, J.-P., Wang, F.-W., Xu, R.-H., & Xie, D. (2019). N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Nature Communications. https://doi.org/10.1038/s41467-019-12651-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
