High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis
Open accessAbstract
Powerful information processing and ubiquitous computing are crucial for all machines and living organisms. The Watson-Crick base-pairing principle endows DNA with excellent recognition and assembly abilities, which facilitates the design of DNA computers for achieving intelligent systems. However, current DNA computational systems are always constrained by poor integration efficiency, complicated device structures or limited computational functions. Here, we show a DNA arithmetic logic unit (ALU) consisting of elemental DNA logic gates using polymerase-mediated strand displacement. The use of an enzyme resulted in highly efficient logic gates suitable for multiple and cascaded computation. Based on our basic single-rail DNA configuration, additional combined logic gates (e.g., a full adder and a 4:1 multiplexer) have been constructed. Finally, we integrate the gates and assemble the crucial ALU. Our strategy provides a facile strategy for assembling a large-scale complex DNA computer system, highlighting the great potential for programming the molecular behaviors of complicated biosystems.
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Recent work on DNA computation has moved away from NP-complete problems toward recreating deterministic logical operations, such as addition and multiplication, with definite outcomes.
“Recent work on DNA computation has moved away from such problems toward recreating deterministic logical operations, for example, addition139 and multiplication,140 with definite outcomes.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [139]
Su et al. produced DNA logic cascades that allow the buildup of a full adder, a 4:1 multiplexer, and, combined with other logic circuits, a DNA arithmetic logic unit (ALU), the foundation of general-purpose processors.
“Su et al. produced DNA logic cascades, which allows the buildup of a full adder, a 4:1 multiplexer, and then, they combined these with other logic circuits to produce a DNA arithmetic logic unit (ALU): the foundation of general-purpose processors.139”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [139]
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Sequential logic circuit built on λ exonuclease for cross inhibition
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Programming and monitoring surface-confined DNA computing
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- Authors
- Su, H., Xu, J., Wang, Q., Wang, F., & Zhou, X.
- Affiliations
- Wuhan University (CN)
- Corresponding author
- Zhou, Xiang
- Venue
- Nature Communications
- Published
- 2019-11-26
- Volume
- 10
- Issue
- 1
- Pages
- 5390-5390
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6879481
- OpenAlex
- W2990086523
- Cited by
- 94
- References
- 28
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 14 · 2023: 16 · 2022: 13 · 2021: 20 · 2020: 12
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (21432008, 91753201, 21721005)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Biomedical Engineering › Nanopore and Nanochannel Transport Studies
- Keywords
- DNA computing, strand displacement synthesis, DNA logic gates, Watson-Crick base pairing, full adder, 4:1 multiplexer
- MeSH terms
- DNA, Single-Stranded, Equipment Design, Logic, Computers, Molecular, Real-Time Polymerase Chain Reaction
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