microRNA Functions

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works

Silencing of microRNAs in vivo with ‘antagomirs’

Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949 · see citing works

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872 · see citing works

The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

Farh, K. K.-H., Grimson, A., Jan, C., Lewis, B. P., Johnston, W. K., Lim, L. P., Burge, C. B., & Bartel, D. P. (2005) · Science · doi:10.1126/science.1121158 · Cited by 1,484 · see citing works

Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M. (2005) · Cell · doi:10.1016/j.cell.2005.11.023 · Cited by 1,080 · see citing works

AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2

Vasudevan, S., & Steitz, J. A. (2007) · Cell · doi:10.1016/j.cell.2007.01.038 · Cited by 656 · see citing works

Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs

Yi, R., O'Carroll, D., Pasolli, H. A., Zhang, Z., Dietrich, F. S., Tarakhovsky, A., & Fuchs, E. (2006) · Nature Genetics · doi:10.1038/ng1744 · Cited by 555 · see citing works

The miRNA-Processing Enzyme Dicer Is Essential for the Morphogenesis and Maintenance of Hair Follicles

Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C. D., Seykora, J. T., Hannon, G. J., & Millar, S. E. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.005 · Cited by 359 · see citing works

MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development

Boutz, P. L., Chawla, G., Stoilov, P., & Black, D. L. (2007) · Genes & Development · doi:10.1101/gad.1500707 · Cited by 304 · see citing works

MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision

Johnston, R. J., Chang, S., Etchberger, J. F., Ortiz, C. O., & Hobert, O. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505530102 · Cited by 276 · see citing works

Regulation of mRNA Translation and Stability by microRNAs

Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214 · see citing works

Export of microRNAs and microRNA-protective protein by mammalian cells

Wang, K., Zhang, S., Weber, J., Baxter, D., & Galas, D. J. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq601 · Cited by 1,002 · see citing works

Translational control of long-lasting synaptic plasticity and memory

Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944 · see citing works

Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes

Shen, D.-W., Pouliot, L. M., Hall, M. D., & Gottesman, M. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005637 · Cited by 955 · see citing works

Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis

Braun, T., & Gautel, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3118 · Cited by 713 · see citing works

MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2

Hou, J., Wang, P., Lin, L., Liu, X., Ma, F., An, H., Wang, Z., & Cao, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900707 · Cited by 739 · see citing works

The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery

Cheng, X., & Lee, R. J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.022 · Cited by 703 · see citing works

Breast milk, a source of beneficial microbes and associated benefits for infant health

Lyons, K. E., Ryan, C. A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Nutrients · doi:10.3390/nu12041039 · Cited by 613 · see citing works

The evolution of cell types in animals: emerging principles from molecular studies

Arendt, D. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2416 · Cited by 525 · see citing works

MicroRNA expression in the adult mouse central nervous system

Bak, M., Silahtaroglu, A., Møller, M., Christensen, M., Rath, M. F., Skryabin, B., Tommerup, N., & Kauppinen, S. (2008) · RNA · doi:10.1261/rna.783108 · Cited by 463 · see citing works

Mechanisms and Regulation of Cellular Senescence

Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395 · see citing works

p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

Christoffersen, N. R., Shalgi, R., Frankel, L. B., Leucci, E., Lees, M., Klausen, M., Pilpel, Y., Nielsen, F. C., Oren, M., & Lund, A. H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.109 · Cited by 352 · see citing works

Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies

Zhu, X.-M., Han, T., Sargent, I. L., Yin, G.-W., & Yao, Y.-Q. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.12.045 · Cited by 345 · see citing works

MicroRNA Expression Is Down-Regulated and Reorganized in Prefrontal Cortex of Depressed Suicide Subjects

Smalheiser, N. R., Lugli, G., Rizavi, H. S., Torvik, V. I., Turecki, G., & Dwivedi, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033201 · Cited by 324 · see citing works

MicroRNAs shape the neuronal landscape

McNeill, E., & Van Vactor, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.005 · Cited by 274 · see citing works

DGCR8-dependent microRNA biogenesis is essential for skin development

Yi, R., Pasolli, H. A., Landthaler, M., Hafner, M., Ojo, T., Sheridan, R., Sander, C., O'Carroll, D., Stoffel, M., Tuschl, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810766105 · Cited by 232 · see citing works

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes # †

Vinciguerra, M., Sgroi, A., Veyrat-Durebex, C., Rubbia-Brandt, L., Buhler, L. H., & Foti, M. (2009) · Hepatology · doi:10.1002/hep.22737 · Cited by 198 · see citing works

miR-21 Regulates Skin Wound Healing by Targeting Multiple Aspects of the Healing Process

Wang, T., Feng, Y., Sun, H., Zhang, L., Hao, L., Shi, C., Wang, J., Li, R., Ran, X., Su, Y., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.08.022 · Cited by 192 · see citing works

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

Kundu, P., Fabian, M. R., Sonenberg, N., Bhattacharyya, S. N., & Filipowicz, W. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks148 · Cited by 180 · see citing works

Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia

Saus, E., Soria, V., Escaramís, G., Vivarelli, F., Crespo, J. M., Kagerbauer, B., Menchón, J. M., Urretavizcaya, M., Gratacòs, M., & Estivill, X. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq316 · Cited by 163 · see citing works

MicroRNA-137 Is a Novel Hypoxia-responsive MicroRNA That Inhibits Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX

Li, W., Zhang, X., Zhuang, H., Chen, H.-G., Chen, Y., Tian, W., Wu, W., Li, Y., Wang, S., Zhang, L., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.537050 · Cited by 145 · see citing works

Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

Aziz, N. M., Guedj, F., Pennings, J. L. A., Olmos-Serrano, J. L., Siegel, A., Haydar, T. F., & Bianchi, D. W. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031013 · Cited by 118 · see citing works

Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A

Luo, R., Wang, Y., Xu, P., Cao, G., Zhao, Y., Shao, X., Li, Y.-X., Chang, C., Peng, C., & Wang, Y.-L. (2016) · Scientific Reports · doi:10.1038/srep19588 · Cited by 100 · see citing works

High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis

Su, H., Xu, J., Wang, Q., Wang, F., & Zhou, X. (2019) · Nature Communications · doi:10.1038/s41467-019-13310-2 · Cited by 94 · see citing works

MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes

Liu, F., Gong, J., Huang, W., Wang, Z., Wang, M., Yang, J., Wu, C., Wu, Z., & Han, B. (2014) · Oncogene · doi:10.1038/onc.2013.428 · Cited by 86 · see citing works

miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions

Cui, H., Ge, J., Xie, N., Banerjee, S., Zhou, Y., Liu, R.-M., Thannickal, V. J., & Liu, G. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00335.2016 · Cited by 66 · see citing works

miRNAs in depression vulnerability and resilience: novel targets for preventive strategies

Lopizzo, N., Zonca, V., Cattane, N., Pariante, C. M., & Cattaneo, A. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02048-2 · Cited by 37 · see citing works

MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease

Yoon, H., Flores, L. F., & Kim, J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.020 · Cited by 23 · see citing works