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Cited by 267

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

Open access
Herster, Franziska, Bittner, Zsofia, Archer, Nathan K., Dickhöfer, Sabine, Eisel, David, Eigenbrod, Tatjana, Knorpp, Thomas, Schneiderhan-Marra, Nicole, Löffler, Markus W., Kalbacher, Hubert, Vierbuchen, Tim, Heine, Holger, Miller, Lloyd S., Hartl, Dominik, Freund, Lukas, Schäkel, Knut, Heister, Martin, Ghoreschi, Kamran, Weber, Alexander N. R.·2020·Nature Communications
DOI 10.1038/s41467-019-13756-4
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Abstract

Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37. LL37 in complex with DNA and RNA is thought to initiate disease exacerbation via plasmacytoid dendritic cells. However, the source of nucleic acids supposed to start this initial inflammatory event remains unknown. We show here that primary murine and human PMNs mount a fulminant and self-propagating neutrophil extracellular trap (NET) and cytokine response, but independently of the canonical NET component, DNA. Unexpectedly, RNA, which is abundant in NETs and psoriatic but not healthy skin, in complex with LL37 triggered TLR8/TLR13-mediated cytokine and NET release by PMNs in vitro and in vivo. Transfer of NETs to naive human PMNs prompts additional NET release, promoting further inflammation. Our study thus uncovers a self-propagating vicious cycle contributing to chronic inflammation in psoriasis, and NET-associated RNA (naRNA) as a physiologically relevant NET component.

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Metadata

Authors
Herster, F., Bittner, Z., Archer, N. K., Dickhöfer, S., Eisel, D., Eigenbrod, T., Knorpp, T., Schneiderhan-Marra, N., Löffler, M. W., Kalbacher, H., Vierbuchen, T., Heine, H., Miller, L. S., Hartl, D., Freund, L., Schäkel, K., Heister, M., Ghoreschi, K., & Weber, A. N. R.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2020-01-08
Volume
11
Issue
1
Pages
105-105
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-019-13756-4
OpenAlex
W2999043338
Cited by
267
References
56
FWCI
9.61
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis. https://app.cochat.ai/papers/10.1038/s41467-019-13756-4
The paper
Herster, F., Bittner, Z., Archer, N. K., Dickhöfer, S., Eisel, D., Eigenbrod, T., Knorpp, T., Schneiderhan-Marra, N., Löffler, M. W., Kalbacher, H., Vierbuchen, T., Heine, H., Miller, L. S., Hartl, D., Freund, L., Schäkel, K., Heister, M., Ghoreschi, K., & Weber, A. N. R. (2020). Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis. Nature Communications. https://doi.org/10.1038/s41467-019-13756-4

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.