The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
Open accessAbstract
Bone marrow stromal cells (BMSCs) are versatile mesenchymal cell populations underpinning the major functions of the skeleton, a majority of which adjoin sinusoidal blood vessels and express C-X-C motif chemokine ligand 12 (CXCL12). However, how these cells are activated during regeneration and facilitate osteogenesis remains largely unknown. Cell-lineage analysis using Cxcl12-creER mice reveals that quiescent Cxcl12-creER+ perisinusoidal BMSCs differentiate into cortical bone osteoblasts solely during regeneration. A combined single cell RNA-seq analysis demonstrate that these cells convert their identity into a skeletal stem cell-like state in response to injury, associated with upregulation of osteoblast-signature genes and activation of canonical Wnt signaling components along the single-cell trajectory. β-catenin deficiency in these cells indeed causes insufficiency in cortical bone regeneration. Therefore, quiescent Cxcl12-creER+ BMSCs transform into osteoblast precursor cells in a manner mediated by canonical Wnt signaling, highlighting a unique mechanism by which dormant stromal cells are enlisted for skeletal regeneration.
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Cites
Integrating single-cell transcriptomic data across different conditions, technologies, and species
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The bone marrow microenvironment at single-cell resolution
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Self-citationStem cells versus plasticity in liver and pancreas regeneration
Kopp, J. L., Grompe, M., & Sander, M. (2016) · Nature Cell Biology · doi:10.1038/ncb3309 · Cited by 176
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A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis
Shen, B., Tasdogan, A., Ubellacker, J. M., Zhang, J., Nosyreva, E. D., Du, L., Murphy, M. M., Hu, S., Yi, Y., Kara, N., et al. (2021) · Nature · doi:10.1038/s41586-021-03298-5 · Cited by 310
Senescent immune cells release grancalcin to promote skeletal aging
Li, C.-J., Xiao, Y., Sun, Y.-C., He, W.-Z., Liu, L., Huang, M., He, C., Huang, M., Chen, K.-X., Hou, J., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.009 · Cited by 190
Application of decellularized bone matrix as a bioscaffold in bone tissue engineering
Amirazad, H., Dadashpour, M., & Zarghami, N. (2022) · Journal of Biological Engineering · doi:10.1186/s13036-021-00282-5 · Cited by 154
Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · Nature Communications · doi:10.1038/s41467-023-40393-9 · Cited by 57
Metadata
- Authors
- Matsushita, Y., Nagata, M., Kozloff, K. M., Welch, J. D., Mizuhashi, K., Tokavanich, N., Hallett, S. A., Link, D. C., Nagasawa, T., Ono, W., & Ono, N.
- Venue
- Nature Communications
- Published
- 2020-01-16
- Volume
- 11
- Issue
- 1
- Pages
- 332-332
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2999129511
- Cited by
- 298
- References
- 6
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Matsushita, Y., Nagata, M., Kozloff, K. M., Welch, J. D., Mizuhashi, K., Tokavanich, N., Hallett, S. A., Link, D. C., Nagasawa, T., Ono, W., & Ono, N. (2020). A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration. Nature Communications. https://doi.org/10.1038/s41467-019-14029-w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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