Stem cells versus plasticity in liver and pancreas regeneration
Abstract
Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.
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Cell plasticity plays an important role in liver regeneration.
“Cell plasticity has lately been recognized to play an important role in liver regeneration (Kopp et al., 2016; Li et al., 2016; Michalopoulos and Khan, 2015”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Kopp et al., 2016
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- Authors
- Kopp, J. L., Grompe, M., & Sander, M.
- Affiliations
- University of British Columbia (CA)
- Oregon Health & Science University (US)
- University of California San Diego (US)
- Corresponding author
- Sander, Maike
- Venue
- Nature Cell Biology
- Published
- 2016-02-25
- Volume
- 18
- Issue
- 3
- Pages
- 238-245
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2285174330
- Cited by
- 176
- References
- 149
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 20 · 2022: 14 · 2021: 25 · 2020: 20 · 2019: 22 · 2018: 19 · 2017: 24 · 2016: 14
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- National Institute of Diabetes and Digestive and Kidney Diseases (UC4DK104143, DK104143, R01DK051592, DK078803, DK068471, DK05192, R01DK078803, R01DK068471)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- liver regeneration, pancreatic regeneration, stem cells, cellular plasticity, transdifferentiation, tissue repair, organ damage, cell replacement
- MeSH terms
- Animals, Cell Differentiation, Humans, Liver, Pancreas, Regeneration, Stem Cells, Cell Transdifferentiation
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