Cited by 176Liver physiology and pathologyPancreatic function and diabetesMesenchymal stem cell research

Stem cells versus plasticity in liver and pancreas regeneration

Kopp, Janel L., Grompe, Markus, Sander, Maike·2016·Nature Cell Biology

Abstract

Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.

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Crossref · 10.1038/ncb3309

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148 of 148 references verified0 citation errors · 0 not checkable

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Authors
Kopp, J. L., Grompe, M., & Sander, M.
Affiliations
  • University of British Columbia (CA)
  • Oregon Health & Science University (US)
  • University of California San Diego (US)
Corresponding author
Sander, Maike
Venue
Nature Cell Biology
Published
2016-02-25
Volume
18
Issue
3
Pages
238-245
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
OpenAlex
W2285174330
Cited by
176
References
149
Citations by year
2026: 2 · 2025: 6 · 2024: 10 · 2023: 20 · 2022: 14 · 2021: 25 · 2020: 20 · 2019: 22 · 2018: 19 · 2017: 24 · 2016: 14
FWCI
3.29
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Funders
  • Canadian Institutes of Health Research
  • National Institute of Diabetes and Digestive and Kidney Diseases (UC4DK104143, DK104143, R01DK051592, DK078803, DK068471, DK05192, R01DK078803, R01DK068471)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
liver regeneration, pancreatic regeneration, stem cells, cellular plasticity, transdifferentiation, tissue repair, organ damage, cell replacement
MeSH terms
Animals, Cell Differentiation, Humans, Liver, Pancreas, Regeneration, Stem Cells, Cell Transdifferentiation

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