The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
Open accessAbstract
Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal tissues and organs in their dormant state. Mechanisms underlying the pre-metastatic niche formation are poorly understood. Here we show that in a colorectal cancer (CRC) model, primary tumors release integrin beta-like 1 (ITGBL1)-rich extracellular vesicles (EVs) to the circulation to activate resident fibroblasts in remote organs. The activated fibroblasts induce the pre-metastatic niche formation and promote metastatic cancer growth by secreting pro-inflammatory cytokine, such as IL-6 and IL-8. Mechanistically, the primary CRC-derived ITGBL1-enriched EVs stimulate the TNFAIP3-mediated NF-κB signaling pathway to activate fibroblasts. Consequently, the activated fibroblasts produce high levels of pro-inflammatory cytokines to promote metastatic cancer growth. These findings uncover a tumor–stromal interaction in the metastatic tumor microenvironment and an intimate signaling communication between primary tumors and metastases through the ITGBL1-loaded EVs. Targeting the EVs-ITGBL1-CAFs-TNFAIP3-NF-κB signaling axis provides an attractive approach for treating metastatic diseases.
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1 retracted
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Metadata
- Authors
- Ji, Q., Zhou, L., Sui, H., Yang, L., Wu, X., Song, Q., Jia, R., Li, R., Sun, J., Wang, Z., Liu, N., Feng, Y., Sun, X., Cai, G., Feng, Y., Cai, J., Cao, Y., Cai, G., Wang, Y., & Li, Q.
- Venue
- Nature Communications
- Published
- 2020-03-05
- Volume
- 11
- Issue
- 1
- Pages
- 1211-1211
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3010606541
- Cited by
- 267
- References
- 63
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ji, Q., Zhou, L., Sui, H., Yang, L., Wu, X., Song, Q., Jia, R., Li, R., Sun, J., Wang, Z., Liu, N., Feng, Y., Sun, X., Cai, G., Feng, Y., Cai, J., Cao, Y., Cai, G., Wang, Y., & Li, Q. (2020). Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation. Nature Communications. https://doi.org/10.1038/s41467-020-14869-x
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