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Cited by 319

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma

Open access
Kong, Bin, Chen, Yun, Liu, Rui, Liu, Xi, Liu, Changyong, Shao, Zengwu, Xiong, Liming, Liu, Xianning, Sun, Wei, Mi, Shengli·2020·Nature Communications

Abstract

Regeneration of corneal stroma has always been a challenge due to its sophisticated structure and keratocyte-fibroblast transformation. In this study, we fabricate grid poly (ε-caprolactone)-poly (ethylene glycol) microfibrous scaffold and infuse the scaffold with gelatin methacrylate (GelMA) hydrogel to obtain a 3 D fiber hydrogel construct; the fiber spacing is adjusted to fabricate optimal construct that simulates the stromal structure with properties most similar to the native cornea. The topological structure (3 D fiber hydrogel, 3 D GelMA hydrogel, and 2 D culture dish) and chemical factors (serum, ascorbic acid, insulin, and β-FGF) are examined to study their effects on the differentiation of limbal stromal stem cells to keratocytes or fibroblasts and the phenotype maintenance, in vitro and in vivo tissue regeneration. The results demonstrate that fiber hydrogel and serum-free media synergize to provide an optimal environment for the maintenance of keratocyte phenotype and the regeneration of damaged corneal stroma.

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Metadata

Authors
Kong, B., Chen, Y., Liu, R., Liu, X., Liu, C., Shao, Z., Xiong, L., Liu, X., Sun, W., & Mi, S.
Venue
Nature Communications
Published
2020-03-18
Volume
11
Issue
1
Pages
1435-1435
ISSN
2041-1723 (ISSN-L)
OpenAlex
W3011813593
Cited by
319
References
52
FWCI
19.16
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma. https://app.cochat.ai/papers/10.1038/s41467-020-14887-9
The paper
Kong, B., Chen, Y., Liu, R., Liu, X., Liu, C., Shao, Z., Xiong, L., Liu, X., Sun, W., & Mi, S. (2020). Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma. Nature Communications. https://doi.org/10.1038/s41467-020-14887-9

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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