The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy
Open accessAbstract
The efficacy of nano-mediated drug delivery has been impeded by multiple biological barriers such as the mononuclear phagocyte system (MPS), as well as vascular and interstitial barriers. To overcome the abovementioned obstacles, we report a nano-pathogenoid (NPN) system that can in situ hitchhike circulating neutrophils and supplement photothermal therapy (PTT). Cloaked with bacteria-secreted outer membrane vesicles inheriting pathogen-associated molecular patterns of native bacteria, NPNs are effectively recognized and internalized by neutrophils. The neutrophils migrate towards inflamed tumors, extravasate across the blood vessels, and penetrate through the tumors. Then NPNs are rapidly released from neutrophils in response to inflammatory stimuli and subsequently taken up by tumor cells to exert anticancer effects. Strikingly, due to the excellent targeting efficacy, cisplatin-loaded NPNs combined with PTT completely eradicate tumors in all treated mice. Such a nano-platform represents an efficient and generalizable strategy towards in situ cell hitchhiking as well as enhanced tumor targeted delivery.
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Cites
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Self-citationMicroenvironment‐Responsive Prodrug‐Induced Pyroptosis Boosts Cancer Immunotherapy
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Wang, J., Tang, W., Yang, M., Yin, Y., Li, H., Hu, F., Tang, L., Ma, X., Zhang, Y., & Wang, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120784 · Cited by 317
Self-citationBacteria‐Based Cancer Immunotherapy
Huang, X., Pan, J., Xu, F., Shao, B., Wang, Y., Guo, X., & Zhou, S. (2021) · Advanced Science · doi:10.1002/advs.202003572 · Cited by 304
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Metadata
- Authors
- Li, M., Li, S., Zhou, H., Tang, X., Wu, Y., Jiang, W., Tian, Z., Zhou, X., Yang, X., & Wang, Y.
- Venue
- Nature Communications
- Published
- 2020-02-28
- Volume
- 11
- Issue
- 1
- Pages
- 1126-1126
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3010033244
- Cited by
- 300
- References
- 60
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, M., Li, S., Zhou, H., Tang, X., Wu, Y., Jiang, W., Tian, Z., Zhou, X., Yang, X., & Wang, Y. (2020). Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy. Nature Communications. https://doi.org/10.1038/s41467-020-14963-0
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