The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease
Open accessAbstract
Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and non-inflamed colonic mucosa [50 Crohn’s disease (CD); 80 ulcerative colitis (UC); 31 controls]. Changes in community-wide and within-patient microbiota are linked with inflammation, but we find no evidence for a distinct microbial diagnostic signature, probably due to heterogeneous host-microbe interactions, and show only marginal microbiota associations with habitual diet. Epithelial DNA methylation improves disease classification and is associated with both inflammation and microbiota composition. Microbiota sub-groups are driven by dominant Enterbacteriaceae and Bacteroides species, representative strains of which are pro-inflammatory in vitro, are also associated with immune-related epigenetic markers. In conclusion, inflamed and non-inflamed colonic segments in both CD and UC differ in microbiota composition and epigenetic profiles.
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Yin, K., Wang, Y., Zhao, H., Wang, D., Guo, M., Mu, M., Liu, Y., Nie, X., Li, B., Li, J., et al. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145758 · Cited by 438
Epigenetic regulation by gut microbiota
Woo, V., & Alenghat, T. (2022) · Gut Microbes · doi:10.1080/19490976.2021.2022407 · Cited by 319
Mechanism of the Gut Microbiota Colonization Resistance and Enteric Pathogen Infection
Khan, I., Bai, Y., Zha, L., Ullah, N., Ullah, H., Shah, S. R. H., Sun, H., & Zhang, C. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.716299 · Cited by 291
Wang, M., Zhou, B., Cong, W., Zhang, M., Li, Z., Li, Y., Liang, S., Chen, K., Yang, D., & Wu, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.797605 · Cited by 71
Sun, X., Chen, Z., Yu, L., Zeng, W., Sun, B., Fan, H., & Bai, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1205323 · Cited by 33
“IBD includes two types: ulcerative colitis (UC) and Crohn’s disease (CD), both of which are associated with gut dysbiosis that occurs after the intestinal microbiota undergoes compositional and metabolic changes (Ni et al., 2017; Shen et al., 2018).”
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Metadata
- Authors
- Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., & Claesson, M. J.
- Venue
- Nature Communications
- Published
- 2020-03-23
- Volume
- 11
- Issue
- 1
- Pages
- 1512-1512
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3012730985
- Cited by
- 285
- References
- 86
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., . . . Claesson, M. J. (2020). Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease. Nature Communications. https://doi.org/10.1038/s41467-020-15342-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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