The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Epigenetic regulation by gut microbiota
Open accessAbstract
The gastrointestinal tract is continuously exposed to trillions of commensal microbes, collectively termed the microbiota, which are environmental stimuli that can direct health and disease within the host. In addition to well-established bacterial sensing pathways, microbial signals are also integrated through epigenetic modifications that calibrate the transcriptional program of host cells without altering the underlying genetic code. Microbiota-sensitive epigenetic changes include modifications to the DNA or histones, as well as regulation of non-coding RNAs. While microbiota-sensitive epigenetic mechanisms have been described in both local intestinal cells and as well in peripheral tissues, further research is required to fully decipher the complex relationship between the host and microbiota. This Review highlights current understandings of epigenetic regulation by gut microbiota and important implications of these findings in guiding therapeutic approaches to prevent or combat diseases driven by impaired microbiota-host interactions.
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Cites
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Cited by
The Role of Short Chain Fatty Acids in Inflammation and Body Health
Du, Y., He, C., An, Y., Huang, Y., Zhang, H., Fu, W., Wang, M., Shan, Z., Xie, J., Yang, Y., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137379 · Cited by 384
The microbiota–gut–brain axis and neurodevelopmental disorders
Wang, Q., Yang, Q., & Liu, X. (2023) · Protein & Cell · doi:10.1093/procel/pwad026 · Cited by 355
Dysbiosis in Inflammatory Bowel Disease: Pathogenic Role and Potential Therapeutic Targets
Santana, P. T., Rosas, S. L. B., Ribeiro, B. E., Marinho, Y., & de Souza, H. S. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073464 · Cited by 325
Intratumoural microbiota: a new frontier in cancer development and therapy
Cao, Y., Xia, H., Tan, X., Shi, C., Ma, Y., Meng, D., Zhou, M., Lv, Z., Wang, S., & Jin, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01693-0 · Cited by 253
Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies
Godos, J., Currenti, W., Ferri, R., Lanza, G., Caraci, F., Frias-Toral, E., Guglielmetti, M., Ferraris, C., Lipari, V., Carvajal Altamiranda, S., et al. (2025) · Nutrients · doi:10.3390/nu17030529 · Cited by 22
Metadata
- Authors
- Woo, V., & Alenghat, T.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2022-01-09
- Volume
- 14
- Issue
- 1
- Pages
- 2022407-2022407
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- OpenAlex
- W4205661039
- Cited by
- 319
- References
- 99
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- gold
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