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Cited by 291Gut microbiota and healthClostridium difficile and Clostridium perfringens researchEscherichia coli research studies

Mechanism of the Gut Microbiota Colonization Resistance and Enteric Pathogen Infection

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Khan, Israr, Bai, Yanrui, Zha, Lajia, Ullah, Naeem, Ullah, Habib, Shah, Syed Rafiq Hussain, Sun, Hui, Zhang, Chunjiang·2021·Frontiers in Cellular and Infection Microbiology
DOI 10.3389/fcimb.2021.716299PMC PMC8733563
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Abstract

The mammalian gut microbial community, known as the gut microbiota, comprises trillions of bacteria, which co-evolved with the host and has an important role in a variety of host functions that include nutrient acquisition, metabolism, and immunity development, and more importantly, it plays a critical role in the protection of the host from enteric infections associated with exogenous pathogens or indigenous pathobiont outgrowth that may result from healthy gut microbial community disruption. Microbiota evolves complex mechanisms to restrain pathogen growth, which included nutrient competition, competitive metabolic interactions, niche exclusion, and induction of host immune response, which are collectively termed colonization resistance. On the other hand, pathogens have also developed counterstrategies to expand their population and enhance their virulence to cope with the gut microbiota colonization resistance and cause infection. This review summarizes the available literature on the complex relationship occurring between the intestinal microbiota and enteric pathogens, describing how the gut microbiota can mediate colonization resistance against bacterial enteric infections and how bacterial enteropathogens can overcome this resistance as well as how the understanding of this complex interaction can inform future therapies against infectious diseases.

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  • Klebsiella pneumoniae is naturally present in the respiratory and gastrointestinal tracts of humans and has a lower occurrence in animals, possibly due to diet, competition with other bacteria, or genetic virulence factors.

    “Klebsiella pneumoniae is naturally present in the respiratory and gastrointestinal tracts of humans and has a lower occurrence in animals, possibly due to diet, competition with other bacteria, or genetic virulence factors [70,71,72].”

    From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [70]

    The Nutrient Competition section (page unavailable) identifies Klebsiella pneumoniae as a pathogen with a mechanism that gives it a growth advantage over gut commensals. The paper also discusses diet and microbial competition generally, but it does not establish that K. pneumoniae naturally inhabits both human respiratory and gastrointestinal tracts, occurs less often in animals, or that the proposed factors explain such a difference. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Khan, I., Bai, Y., Zha, L., Ullah, N., Ullah, H., Shah, S. R. H., Sun, H., & Zhang, C.
Affiliations
  • Lanzhou University Second Hospital (CN)
  • Lanzhou University (CN)
  • Dalian Medical University (CN)
Corresponding author
  • Sun, Hui
  • Zhang, Chunjiang
ORCID
Venue
Frontiers in Cellular and Infection Microbiology
Publisher
Frontiers Media SA
Published
2021-12-23
Volume
11
Pages
716299-716299
ISSN
2235-2988 (ISSN-L)
DOI
10.3389/fcimb.2021.716299
PMC
PMC8733563
OpenAlex
W4200078072
Cited by
291
References
29
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2026: 60 · 2025: 79 · 2024: 79 · 2023: 54 · 2022: 19
FWCI
3.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lanzhou University Institutional Repository (submittedVersion, cc-by-nc-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords
gut microbiota, colonization resistance, enteric pathogens, nutrient competition, host immune response, pathogen virulence, dysbiosis, host defense against infection
MeSH terms
Gastrointestinal Microbiome, Animals, Bacteria, Bacterial Infections, Virulence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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