The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
Open accessAbstract
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study.
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“The regression model explained, on average, 14% of the variance in serum 25(OH)D, which is consistent with previous research (Manousaki et al. 2020; Revez et al. 2020) (for detailed results see SI2).”
From Vitamin D status and its determinants in German elite athletes (2025) · cites this paper as Revez et al. 2020
In the citing paper
“Genome-wide association studies (GWAS) estimate the heritability of serum 25(OH)D levels between 13 and 16% (Manousaki et al. 2020; Revez et al. 2020).”
From Vitamin D status and its determinants in German elite athletes (2025) · cites this paper as Revez et al. 2020
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Cited by
The health effects of vitamin D supplementation: Evidence from human studies
Bouillon, R., Manousaki, D., Rosen, C., Trajanoska, K., Rivadeneira, F., & Richards, J. B. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00593-z · Cited by 535
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Baselmans, B. M. L., Yengo, L., van Rheenen, W., & Wray, N. R. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.034 · Cited by 132
Self-citationTriangulating Evidence through the Inclusion of Genetically Informed Designs
Munafò, M. R., Higgins, J. P. T., & Smith, G. D. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a040659 · Cited by 125
Vitamin D status and its determinants in German elite athletes
Hacker, S., Lenz, C., Reichert, L., Ringseis, R., Zentgraf, K., & Krüger, K. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05699-6 · Cited by 9
Metadata
- Authors
- Revez, J. A., Lin, T., Qiao, Z., Xue, A., Holtz, Y., Zhu, Z., Zeng, J., Wang, H., Sidorenko, J., Kemper, K. E., Vinkhuyzen, A. A. E., Frater, J., Eyles, D., Burne, T. H. J., Mitchell, B., Martin, N. G., Zhu, G., Visscher, P. M., Yang, J., Wray, N. R., & McGrath, J. J.
- Venue
- Nature Communications
- Published
- 2020-04-02
- Volume
- 11
- Issue
- 1
- Pages
- 1647-1647
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3014565260
- Cited by
- 415
- References
- 35
- FWCI
- 27.29
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Revez, J. A., Lin, T., Qiao, Z., Xue, A., Holtz, Y., Zhu, Z., Zeng, J., Wang, H., Sidorenko, J., Kemper, K. E., Vinkhuyzen, A. A. E., Frater, J., Eyles, D., Burne, T. H. J., Mitchell, B., Martin, N. G., Zhu, G., Visscher, P. M., Yang, J., . . . McGrath, J. J. (2020). Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration. Nature Communications. https://doi.org/10.1038/s41467-020-15421-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
