Risk in Relatives, Heritability, SNP-Based Heritability, and Genetic Correlations in Psychiatric Disorders: A Review
Abstract
The genetic contribution to psychiatric disorders is observed through the increased rates of disorders in the relatives of those diagnosed with disorders. These increased rates are observed to be nonspecific; for example, children of those with schizophrenia have increased rates of schizophrenia but also a broad range of other psychiatric diagnoses. While many factors contribute to risk, epidemiological evidence suggests that the genetic contribution carries the highest risk burden. The patterns of inheritance are consistent with a polygenic architecture of many contributing risk loci. The genetic studies of the past decade have provided empirical evidence identifying thousands of DNA variants associated with psychiatric disorders. Here, we describe how these latest results are consistent with observations from epidemiology. We provide an R tool (CHARRGe) to calculate genetic parameters from epidemiological parameters and vice versa. We discuss how the single nucleotide polymorphism-based estimates of heritability and genetic correlation relate to those estimated from family records.
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- Authors
- Baselmans, B. M. L., Yengo, L., van Rheenen, W., & Wray, N. R.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Wray, Naomi R.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 89
- Issue
- 1
- Pages
- 11-19
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W3035071780
- Cited by
- 132
- References
- 71
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 22 · 2023: 18 · 2022: 19 · 2021: 10 · 2020: 5
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- ZonMw
- EU Joint Programme – Neurodegenerative Disease Research
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- mental illness, genetic risk, heritability, genetic correlation, single nucleotide polymorphisms, polygenic architecture, family studies, schizophrenia, genetic parameters, genetic susceptibility loci
- MeSH terms
- Child, Humans, Schizophrenia, Genetic Predisposition to Disease, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Genome-Wide Association Study
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