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Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
Open accessAbstract
Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy.
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The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
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Metadata
- Authors
- Hu, F., Jiang, X., Guo, C., Li, Y., Chen, S., Zhang, W., Du, Y., Wang, P., Zheng, X., Fang, X., Li, X., Song, J., Xie, Y., Huang, F., Xue, J., Bai, M., Jia, Y., Liu, X., Ren, L., Zhang, X., Guo, J., Pan, H., Su, Y., Yi, H., Ye, H., Zuo, D., Li, J., Wu, H., Wang, Y., Li, R., Liu, L., Wang, X.-Y., & Li, Z.
- Venue
- Nature Communications
- Published
- 2020-04-20
- Volume
- 11
- Issue
- 1
- Pages
- 1911-1911
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3016349400
- Cited by
- 418
- References
- 1
- FWCI
- 63.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hu, F., Jiang, X., Guo, C., Li, Y., Chen, S., Zhang, W., Du, Y., Wang, P., Zheng, X., Fang, X., Li, X., Song, J., Xie, Y., Huang, F., Xue, J., Bai, M., Jia, Y., Liu, X., Ren, L., . . . Li, Z. (2020). Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study. Nature Communications. https://doi.org/10.1038/s41467-020-15700-3
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