The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Transplantation of discarded livers following viability testing with normothermic machine perfusion
Open accessAbstract
There is a limited access to liver transplantation, however, many organs are discarded based on subjective assessment only. Here we report the VITTAL clinical trial (ClinicalTrials.gov number NCT02740608) outcomes, using normothermic machine perfusion (NMP) to objectively assess livers discarded by all UK centres meeting specific high-risk criteria. Thirty-one livers were enroled and assessed by viability criteria based on the lactate clearance to levels ≤2.5 mmol/L within 4 h. The viability was achieved by 22 (71%) organs, that were transplanted after a median preservation time of 18 h, with 100% 90-day survival. During the median follow up of 542 days, 4 (18%) patients developed biliary strictures requiring re-transplantation. This trial demonstrates that viability testing with NMP is feasible and in this study enabled successful transplantation of 71% of discarded livers, with 100% 90-day patient and graft survival; it does not seem to prevent non-anastomotic biliary strictures in livers donated after circulatory death with prolonged warm ischaemia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dindo, D., Demartines, N., & Clavien, P.-A. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133083.54934.ae · Cited by 31,378
Optimal two-stage designs for phase II clinical trials.
Simon, R. (1989) · Controlled Clinical Trials · doi:10.1016/0197-2456(89)90015-9 · Cited by 3,636
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature · doi:10.1038/nature13909 · Cited by 2,907
Characteristics Associated with Liver Graft Failure: The Concept of a Donor Risk Index
Feng, S., Goodrich, N. P., Bragg-Gresham, J. L., Dykstra, D. M., Punch, J. D., DebRoy, M. A., Greenstein, S. M., & Merion, R. M. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01242.x · Cited by 1,958
Olthoff, K. M., Kulik, L., Samstein, B., Kaminski, M., Abecassis, M., Emond, J., Shaked, A., & Christie, J. D. (2010) · Liver Transplantation · doi:10.1002/lt.22091 · Cited by 1,256
A randomized trial of normothermic preservation in liver transplantation
for the Consortium for Organ Preservation in Europe, Nasralla, D., Coussios, C. C., Mergental, H., Akhtar, M. Z., Butler, A. J., Ceresa, C. D. L., Chiocchia, V., Dutton, S. J., García-Valdecasas, J. C., et al. (2018) · Nature · doi:10.1038/s41586-018-0047-9 · Cited by 1,199
Self-citationRISK FACTORS FOR PRIMARY DYSFUNCTION AFTER LIVER TRANSPLANTATION—A MULTIVARIATE ANALYSIS
PLOEG, R. J., DʼALESSANDRO, A. M., KNECHTLE, S. J., STEGALL, M. D., PIRSCH, J. D., HOFFMANN, R. M., SASAKI, T., SOLLINGER, H. W., BELZER, F. O., & KALAYOGLU, M. (1993) · Transplantation · doi:10.1097/00007890-199304000-00024 · Cited by 1,026
Dutkowski, P., Oberkofler, C. E., Slankamenac, K., Puhan, M. A., Schadde, E., Müllhaupt, B., Geier, A., & Clavien, P. A. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e3182365081 · Cited by 424
OPTN/SRTR 2016 Annual Data Report: Liver
Kim, W. R., Lake, J. R., Smith, J. M., Schladt, D. P., Skeans, M. A., Harper, A. M., Wainright, J. L., Snyder, J. J., Israni, A. K., & Kasiske, B. L. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14559 · Cited by 401
Foley, D. P., Fernandez, L. A., Leverson, G., Anderson, M., Mezrich, J., Sollinger, H. W., & D'Alessandro, A. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e3182104784 · Cited by 400
Cited by
The Immunological Basis of Liver Allograft Rejection
Ronca, V., Wootton, G., Milani, C., & Cain, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02155 · Cited by 160
Authors, & Collaborators: (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2388 · Cited by 30
Metadata
- Authors
- Mergental, H., Laing, R. W., Kirkham, A. J., Perera, M. T. P. R., Boteon, Y. L., Attard, J., Barton, D., Curbishley, S., Wilkhu, M., Neil, D. A. H., Hübscher, S. G., Muiesan, P., Isaac, J. R., Roberts, K. J., Abradelo, M., Schlegel, A., Ferguson, J., Cilliers, H., Bion, J., Adams, D. H., Morris, C., Friend, P. J., Yap, C., Afford, S. C., & Mirza, D. F.
- Venue
- Nature Communications
- Published
- 2020-06-16
- Volume
- 11
- Issue
- 1
- Pages
- 2939-2939
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3024418144
- Cited by
- 489
- References
- 27
- FWCI
- 52.16
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Transplantation of discarded livers following viability testing with normothermic machine perfusion. https://app.cochat.ai/papers/10.1038/s41467-020-16251-3
- The paper
- Mergental, H., Laing, R. W., Kirkham, A. J., Perera, M. T. P. R., Boteon, Y. L., Attard, J., Barton, D., Curbishley, S., Wilkhu, M., Neil, D. A. H., Hübscher, S. G., Muiesan, P., Isaac, J. R., Roberts, K. J., Abradelo, M., Schlegel, A., Ferguson, J., Cilliers, H., Bion, J., . . . Mirza, D. F. (2020). Transplantation of discarded livers following viability testing with normothermic machine perfusion. Nature Communications. https://doi.org/10.1038/s41467-020-16251-3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
